The influence of maternal body mass index, maternal diabetes mellitus, and maternal smoking during pregnancy on the risk of childhood‐onset type 1 diabetes mellitus in the offspring: Systematic review and meta‐analysis of observational studies

2019 ◽  
Author(s):  
Khemayanto Hidayat ◽  
Sheng‐Yi Zou ◽  
Bi‐Min Shi
Keyword(s):  
Diabetes Mellitus ◽  
Observational Studies ◽  
Meta Analysis ◽  
Maternal Diabetes ◽  
Maternal Body Mass Index ◽  
Childhood Onset ◽  
Smoking During Pregnancy ◽  
Maternal Smoking During Pregnancy ◽  
Maternal Diabetes Mellitus

scholarly journals Association of PTPN22 1858C/T Polymorphism with Autoimmune Diseases: A Systematic Review and Bayesian Approach

2019 ◽  
Vol 8 (3) ◽  
pp. 347 ◽  
Author(s):  
Kalthoum Tizaoui ◽  
Seon Kim ◽  
Gwang Jeong ◽  
Andreas Kronbichler ◽  
Kwang Lee ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Diabetes Mellitus ◽  
Juvenile Idiopathic Arthritis ◽  
Autoimmune Diseases ◽  
Observational Studies ◽  
Meta Analysis ◽  
P Value ◽  
Bayesian Approaches ◽  
Anca Associated Vasculitis

The 1858T allele in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) locus shows one of the strongest and most consistent genetic associations with autoimmune diseases. We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. This work examined their validity to discover false positive results under Bayesian methods. We conducted a PubMed search to identify relevant publications and extracted the respective results, published until 30 November 2018. In observational studies, the associations of 1858 C/T genetic variant were noteworthy for 12 autoimmune or autoimmunity-related diseases (rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, juvenile idiopathic arthritis, Crohn’s disease, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, vitiligo, Graves’ disease, myasthenia gravis, Addison’s disease, giant cell arteritis, and endometriosis). In contrast, we could not confirm the noteworthiness for eight diseases (systemic sclerosis, psoriasis, Behçet’s disease, autoimmune thyroid disease, alopecia areata, Sjögren’s syndrome, inflammatory bowel disease, and ankylosing spondylitis). From the meta-analysis of genome-wide association studies (GWAS) with a p-value < 5 × 10−8, findings verified noteworthiness for all autoimmune diseases (psoriatic arthritis, myasthenia gravis, juvenile idiopathic arthritis and rheumatoid arthritis). The results from meta-analysis of GWAS showing a p-value ranging between 0.05 and 5 × 10−8 were noteworthy under both Bayesian approaches (ANCA-associated vasculitis, type 1 diabetes mellitus, giant cell arteritis and juvenile idiopathic arthritis). Re-analysis of observational studies and GWAS by Bayesian approaches revealed the noteworthiness of all significant associations observed by GWAS, but noteworthiness could not be confirmed for all associations found in observational studies.

Sign in / Sign up

Export Citation Format

Share Document