scholarly journals More than just CO2-recycling: corticular photosynthesis as a mechanism to reduce the risk of an energy crisis induced by low oxygen

2018 ◽  
Vol 219 (2) ◽  
pp. 551-564 ◽  
Author(s):  
Christiane Wittmann ◽  
Hardy Pfanz
Keyword(s):  
Energy Crisis ◽  
Low Oxygen ◽  
Corticular Photosynthesis ◽  
Co2 Recycling

HIF1-α-Mediated Gene Expression Induced by Vitamin B1 Deficiency

2013 ◽  
Vol 83 (3) ◽  
pp. 188-197 ◽  
Author(s):  
Rebecca L. Sweet ◽  
Jason A. Zastre
Keyword(s):  
Gene Expression ◽  
Thiamine Deficiency ◽  
Glucose Transporter ◽  
Neuroblastoma Cell ◽  
Hypoxia Inducible Factor ◽  
Clinical Manifestations ◽  
Vitamin B1 ◽  
Low Oxygen ◽  
Glucose Transporter 1 ◽  
Metabolic Intermediates

It is well established that thiamine deficiency results in an excess of metabolic intermediates such as lactate and pyruvate, which is likely due to insufficient levels of cofactor for the function of thiamine-dependent enzymes. When in excess, both pyruvate and lactate can increase the stabilization of the hypoxia-inducible factor 1-alpha (HIF-1α) transcription factor, resulting in the trans-activation of HIF-1α regulated genes independent of low oxygen, termed pseudo-hypoxia. Therefore, the resulting dysfunction in cellular metabolism and accumulation of pyruvate and lactate during thiamine deficiency may facilitate a pseudo-hypoxic state. In order to investigate the possibility of a transcriptional relationship between hypoxia and thiamine deficiency, we measured alterations in metabolic intermediates, HIF-1α stabilization, and gene expression. We found an increase in intracellular pyruvate and extracellular lactate levels after thiamine deficiency exposure to the neuroblastoma cell line SK-N-BE. Similar to cells exposed to hypoxia, there was a corresponding increase in HIF-1α stabilization and activation of target gene expression during thiamine deficiency, including glucose transporter-1 (GLUT1), vascular endothelial growth factor (VEGF), and aldolase A. Both hypoxia and thiamine deficiency exposure resulted in an increase in the expression of the thiamine transporter SLC19A3. These results indicate thiamine deficiency induces HIF-1α-mediated gene expression similar to that observed in hypoxic stress, and may provide evidence for a central transcriptional response associated with the clinical manifestations of thiamine deficiency.

The Other Energy Crisis

PsycCRITIQUES ◽  
2010 ◽  
Vol 55 (24) ◽  
Author(s):  
Randall C. Flanery
Keyword(s):  
The Other ◽  
Energy Crisis

Energy Crisis and Cosmonautics

2005 ◽  
Author(s):  
V.M. Melnikov ◽  
V.A. Komkov ◽  
V.P. Senkevich
Keyword(s):  
Energy Crisis

BÖHLER H521

Alloy Digest ◽  
2017 ◽  
Vol 66 (12) ◽  
Keyword(s):  
High Temperature ◽  
Physical Properties ◽  
Tensile Properties ◽  
Heat Treating ◽  
High Temperature Strength ◽  
Low Oxygen ◽  
Good Resistance ◽  
Temperature Performance

Abstract Böhler (or Boehler) H521 is an alloy with superior high-temperature strength, excellent toughness, and with good resistance to oxidizing, nitrogenous, and low oxygen gases. This datasheet provides information on composition, physical properties, hardness, elasticity, and tensile properties as well as creep. It also includes information on high temperature performance as well as forming, heat treating, machining, and joining. Filing Code: SS-1272. Producer or source: Böhler Edelstahl GmbH.

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