Increased visceral sensitivity, elevated anxiety, and depression levels in patients with functional esophageal disorders and non‐erosive reflux disease

2021 ◽  
Author(s):  
Marco Losa ◽  
Salomon M. Manz ◽  
Valeria Schindler ◽  
Edoardo Savarino ◽  
Daniel Pohl
Keyword(s):  
Reflux Disease ◽  
Anxiety And Depression ◽  
Visceral Sensitivity

Effects of Anxiety and Depression in Patients With Gastroesophageal Reflux Disease

2015 ◽  
Vol 13 (6) ◽  
pp. 1089-1095.e1 ◽  
Author(s):  
Boudewijn F. Kessing ◽  
Albert J. Bredenoord ◽  
Caroline M.G. Saleh ◽  
André J.P.M. Smout
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Anxiety And Depression

scholarly journals Features of psychoemotional status and eating disorders in patients with gastroesophageal reflux disease and obesity

2021 ◽  
Vol 23 (5) ◽  
pp. 412-416
Author(s):  
Georgy L. Yurenev ◽  
◽  
Ekaterina M. Mironova ◽  
Natalia A. Sirota ◽  
Tamara V. Yureneva-Tkhorzhevskaya ◽  
...  
Keyword(s):  
Risk Factors ◽  
Eating Disorders ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Eating Behavior ◽  
Reflux Disease ◽  
Anxiety And Depression ◽  
Obese Patients ◽  
History Of ◽  
Depressive States

Background. Eating disorders, as well as features of the psychoemotional status as risk factors for obesity, patients with comorbid gastroesophageal reflux disease (GERD) and obesity in the modern literature are not sufficiently disclosed. Further study of these aspects may be one of the additional ways to improve the prognosis of the course of GERD, as well as the correction of the psychoemotional status of patients. Aim. To study the features of the course of GERD in concomitant obesity in the context of the peculiarities of the psychoemotional sphere, as well as to identify the types of eating disorders in this cohort of patients. Materials and methods. The study included 130 patients aged 24 to 72 years with complaints characteristic of the pathology of the upper digestive tract, who, along with a detailed analysis of complaints in order to verify the diagnosis and identify the features of the course of the disease, were tested with the Dutch Eating Behavior Questionnaire (DEBQ) and the hospital scale of anxiety and depression (HADS). Results. It was found that obese patients who had GERD less than 8 years ago were more likely to suffer from external and emotionogenic eating disorders, and the external type was more often associated with the male, and the emotionogenic type with the female sex. Whereas, in patients with obesity and a history of GERD for more than 8 years, the restrictive and emotionogenic types of eating disorders were relatively more often recorded. An increased level of anxiety in patients with GERD was noted, both against the background of obesity and without it, but those with comorbid pathology had a relatively higher score on the anxiety scale. Conclusion. Correction of eating behavior and signs of anxiety-depressive states in patients can open up new prospects for the fight against obesity. And this, in turn, can improve the prognosis of patients with GERD.

scholarly journals Motor function of the proximal stomach and visceral perception in gastro-oesophageal reflux disease

Gut ◽  
1998 ◽  
Vol 42 (2) ◽  
pp. 251-257 ◽  
Author(s):  
R Penagini ◽  
G Hebbard ◽  
M Horowitz ◽  
J Dent ◽  
H Bermingham ◽  
...  
Keyword(s):  
Motor Function ◽  
Reflux Disease ◽  
Lower Oesophageal Sphincter ◽  
Visceral Sensitivity ◽  
Visceral Perception ◽  
Proximal Stomach ◽  
Gastric Tone ◽  
Gastric Motor Function ◽  
Delayed Recovery ◽  
Historical Controls

Background—The abnormally high postprandial rate of transient lower oesophageal sphincter relaxations seen in patients with reflux disease may be related to altered proximal gastric motor function. Heightened visceral sensitivity may also contribute to reporting of symptoms in these patients.Aims—To assess motor function of the proximal stomach and visceral perception in reflux disease with a barostat.Methods—Fasting and postprandial proximal gastric motility, sensation, and symptoms were measured in nine patients with reflux disease and nine healthy subjects. Gastric emptying of solids and liquids was assessed in six of the patients on a different day (and compared to historical controls).Results—Minimal distending pressure and gastric compliance were similar in the two groups, whereas the patients experienced fullness at lower pressures (p<0.05) and discomfort at lower balloon volumes (p<0.005) during isobaric and isovolumetric distensions respectively. Maximal gastric relaxation induced by the meal was similar in the two groups. Late after the meal, however, proximal gastric tone was lower (p<0.01) and the score for fullness higher (p<0.01) in the reflux patients, in whom the retention of both solids and liquids in the proximal stomach was greater (p<0.05).Conclusions—Reflux disease is associated with delayed recovery of proximal gastric tone after a meal and increased visceral sensitivity. The former may contribute to the increased prevalence of reflux during transient lower oesophageal sphincter relaxations and the delay in emptying from the proximal stomach, whereas both may contribute to symptom reporting.

scholarly journals Gastroesophageal Reflux Disease in the Young Population and Its Correlation With Anxiety and Depression

Cureus ◽  
2021 ◽  
Author(s):  
Pooja Bai ◽  
Shehar Bano ◽  
Sameet Kumar ◽  
Priyanka Sachdev ◽  
Ahmed Ali ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Anxiety And Depression ◽  
Young Population

scholarly journals Correlation of gastro-oesophageal reflux disease with psycological factors: A viscous cycle?

2021 ◽  
Vol 1 (5) ◽  
Author(s):  
Akriti Sharma ◽  
◽  
Garima Singal ◽  
Urvi Saini ◽  
◽  
...  
Keyword(s):  
Central Nervous System ◽  
Reflux Disease ◽  
Psychological Factors ◽  
Intestinal Tract ◽  
The Other ◽  
Anxiety And Depression ◽  
History Of ◽  
The Central Nervous System ◽  
Gastro Intestinal Tract ◽  
The Brain

Gastroesophageal reflux disease (GERD), a disorder of the gastro-intestinal tract is often associated with psychological factors such as anxiety and depression. Researchers across the globe are divided in their views about psychological factors being the cause or sequalae of GERD. While some researchers believe that psychiatric disorders contribute to GERD, others suggest that unresolved GERD leads to symptoms of anxiety and depression. Through this article we aim to highlight, that the brain-gut axis acts as a strong link between the central nervous system and Gastrointestinal tract and that there is a likelihood of a viscous cycle of psychological factors leading to symptoms of GERD, and unresolved GERD contributing to further worsening of psychological illnesses. In our opinion, while treating patients for either of the two disorders, history of the other one needs to be excluded and if GERD and psychological illnesses are found to co-exist, the two must be treated simultaneously as the treatment of one maybe incomplete without treatment of the other.

scholarly journals High resolution esophageal manometry and life exposure factors in non-cardiac chest pain patients with refractory gastroesophageal reflux disease

2019 ◽  
Author(s):  
Yuan Li ◽  
Peicong Lyu ◽  
Zhifeng Zhang ◽  
Liya Wang ◽  
Xiaoyu Sun ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chest Pain ◽  
High Resolution ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Esophageal Manometry ◽  
Therapeutic Strategies ◽  
Anxiety And Depression ◽  
Esophageal Sphincter

Abstract Background: Refractory gastroesophageal reflux disease (RGERD) is defined by the presence of troublesome GERD symptoms despite proton pump inhibitors (PPIs) treatments for 8-12 weeks. Non-cardiac chest pain (NCCP) is the most common atypical presentations. This study was aimed at clarifying the features of High Resolution Esophageal Manometry (HREM) and life exposure factors of NCCP in RGERD patients for guiding further therapeutic strategies. Methods: 83 RGERD patients were enrolled, in which 44 patients afflicted with NCCP as P group and 39 patients without NCCP as NP group. According to the endoscopy results, P group was further divided into reflux esophagitis group (RE group), non-erosive reflux disease group (NERD group) and Barrett’s esophagus group (BE group). HREM was performed to assess esophageal motility. Diverse questionnaires were conducted to evaluate severity of symptoms, quality of life, risk factors, degrees of anxiety and depression and so on. Results: a)Average resting pressures of the lower esophageal sphincter (LES), residual pressures of the LES and the esophageal distal contractile integral (DCI) score in P group were significantly lower than those in NP group (p<0.05). b)Average resting pressures of the upper esophageal sphincter (UES), residual pressures of the UES, lengths of the LES and the UES showed no difference between the two groups (p>0.05). c)Compared with NP group, the patients in P group had higher exposure to alcohol, coffee, sweets, overeating and stress (p<0.05). d)Anxiety and depression status of patients in P group were remarkably severer than those in NP group (p<0.05). e)The pain intensity in RE group and BE group was higher than NERD group (P<0.05), while there was no difference between RE group and BE group (P>0.05). Conclusions: Esophageal motility related anti-reflux barriers are much weaker in the RGERD patients with NCCP than those without NCCP, which mainly presents as the much lower average resting and residual pressures of the LES and DCI. Alcohol, coffee, sweets, overeating, stress, anxiety and depression are risk factors of RGERD-related NCCP. It’s suggested that the recovery of anti-reflux barriers and the avoidance of risk factors may be essential therapeutic strategies for improving the curative effect.

scholarly journals Visceral hypersensitivity is associated with GI symptom severity in functional GI disorders: consistent findings from five different patient cohorts

Gut ◽  
2017 ◽  
Vol 67 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Magnus Simrén ◽  
Hans Törnblom ◽  
Olafur S Palsson ◽  
Miranda A L van Tilburg ◽  
Lukas Van Oudenhove ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Symptom Severity ◽  
Gastric Fundus ◽  
Visceral Hypersensitivity ◽  
Medium Effect ◽  
Anxiety And Depression ◽  
General Tendency ◽  
Visceral Sensitivity ◽  
Sensitivity Testing ◽  
Large Patient

ObjectiveOur aim was to evaluate the association between visceral hypersensitivity and GI symptom severity in large cohorts of patients with functional GI disorder (FGID) and to adjust for psychological factors and general tendency to report symptoms.DesignWe included five cohorts of patients with FGIDs (IBS or functional dyspepsia; n=1144), who had undergone visceral sensitivity testing using balloon distensions (gastric fundus, descending colon or rectum) and completed questionnaires to assess GI symptom severity, non-GI somatic symptoms, anxiety and depression. Subjects were divided into sensitivity tertiles based on pain/discomfort thresholds. GI symptom severity was compared between sensitivity tertiles in each cohort and corrected for somatisation, and anxiety and depression.ResultsIn all five cohorts, GI symptom severity increased gradually with increasing visceral sensitivity, with significant differences in GI symptom severity between the sensitivity tertiles (p<0.0001), with small to medium effect sizes (partial η2: 0.047–0.11). The differences between sensitivity tertiles remained significant in all cohorts after correction for anxiety and depression, and also after correction for non-GI somatic symptom reporting in all of the cohorts (p<0.05).ConclusionsA gradual increase in GI symptom severity with increasing GI sensitivity was demonstrated in IBS and functional dyspepsia, which was consistent across several large patient groups from different countries, different methods to assess sensitivity and assessments in different parts of the GI tract. This association was independent of tendency to report symptoms or anxiety/depression comorbidity. These findings confirm that visceral hypersensitivity is a contributor to GI symptom generation in FGIDs.

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