scholarly journals Use of the functional luminal imaging probe in pediatrics: A comparison study of patients with achalasia before and after endoscopic dilation and non‐achalasia controls

2021 ◽  
Author(s):  
Alain J. Benitez ◽  
Stephen Budhu ◽  
Cassandra Burger ◽  
Rossella Turco ◽  
Lance Ballester ◽  
...  
Keyword(s):  
Comparison Study ◽  
Endoscopic Dilation ◽  
Imaging Probe ◽  
Before And After ◽  
Functional Luminal Imaging Probe

scholarly journals Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry

2019 ◽  
Vol 17 (4) ◽  
pp. 674-681.e1 ◽  
Author(s):  
Dustin A. Carlson ◽  
Wenjun Kou ◽  
Zhiyue Lin ◽  
Monique Hinchcliff ◽  
Anjali Thakrar ◽  
...  
Keyword(s):  
Normal Values ◽  
Imaging Probe ◽  
Functional Luminal Imaging Probe

scholarly journals Mechanisms of repetitive retrograde contractions in response to sustained esophageal distension: a study evaluating patients with postfundoplication dysphagia

2018 ◽  
Vol 314 (3) ◽  
pp. G334-G340 ◽  
Author(s):  
Dustin A. Carlson ◽  
Peter J. Kahrilas ◽  
Katherine Ritter ◽  
Zhiyue Lin ◽  
John E. Pandolfino
Keyword(s):  
Nissen Fundoplication ◽  
Motor Disorder ◽  
Outflow Obstruction ◽  
Imaging Probe ◽  
High Resolution Manometry ◽  
Type Iii ◽  
Common Response ◽  
Barium Esophagram ◽  
Functional Luminal Imaging Probe ◽  
Type Iii Achalasia

Repetitive retrograde contractions (RRCs) in response to sustained esophageal distension are a distinct contractility pattern observed with functional luminal imaging probe (FLIP) panometry that are common in type III (spastic) achalasia. RRCs are hypothesized to be indicative of either impaired inhibitory innervation or esophageal outflow obstruction. We aimed to apply FLIP panometry to patients with postfundoplication dysphagia (a model of esophageal obstruction) to explore mechanisms behind RRCs. Adult patients with dysphagia after Nissen fundoplication ( n = 32) or type III achalasia ( n = 25) were evaluated with high-resolution manometry (HRM) and upper endoscopy with FLIP. HRM studies were assessed for outflow obstruction and spastic features: premature contractility, hypercontractility, and impaired deglutitive inhibition during multiple-rapid swallows. FLIP studies were analyzed to determine the esophagogastric junction (EGJ)-distensibility index and contractility pattern, including RRCs. Barium esophagram was evaluated when available. RRCs were present in 8/32 (25%) fundoplication and 19/25 (76%) achalasia patients ( P < 0.001). EGJ outflow obstruction was detected in 21 (67%) fundoplication patients by HRM, FLIP, or esophagram [6 (29%) had RRCs]. On HRM, none of the fundoplication patients had premature contractility, whereas 3/4 with defective inhibition on multiple-rapid swallows and 2/4 with hypercontractility had RRCs. Regression analysis demonstrated HRM with spastic features, but not esophageal outflow obstruction, as a predictor for RRCs. RRCs in response to sustained esophageal distension appear to be a manifestation of spastic esophageal motility. Although future study to further clarify the significance of RRCs is needed, RRCs on FLIP panometry should prompt evaluation for a major motor disorder. NEW & NOTEWORTHY Repetitive retrograde contractions (RRCs) are a common response to sustained esophageal distension among spastic achalasia patients when evaluated with the functional luminal imaging probe. We evaluated patients with postfundoplication dysphagia, i.e., patients with suspected mechanical obstruction, and found that RRCs occasionally occurred among postfundoplication patients, but often in association with manometric features of esophageal neuromuscular imbalance. Thus, RRCs appear to be a manifestation of spastic esophageal dysmotility, likely from neural imbalance resulting in excess excitation.

scholarly journals Functional Luminal Imaging Probe Panometry Identifies Achalasia-Type Esophagogastric Junction Outflow Obstruction

2020 ◽  
Vol 18 (10) ◽  
pp. 2209-2217 ◽  
Author(s):  
Joseph R. Triggs ◽  
Dustin A. Carlson ◽  
Claire Beveridge ◽  
Wenjun Kou ◽  
Peter J. Kahrilas ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Outflow Obstruction ◽  
Imaging Probe ◽  
Functional Luminal Imaging Probe

T1972 Mechanics of the Esophagogastric Junction in Postfundoplication Patients As Assessed By Functional Luminal Imaging Probe

2008 ◽  
Vol 134 (4) ◽  
pp. A-591 ◽  
Author(s):  
Monika A. Kwiatek ◽  
William J. Bulsiewicz ◽  
Sudip K. Ghosh ◽  
Barry P. McMahon ◽  
Hans Gregersen ◽  
...  
Keyword(s):  
Esophagogastric Junction ◽  
Imaging Probe ◽  
Functional Luminal Imaging Probe

scholarly journals A Type I Collagen-Targeted MR Imaging Probe for Staging Fibrosis in Crohn’s Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhoulei Li ◽  
Baolan Lu ◽  
Jinjiang Lin ◽  
Shaofu He ◽  
Li Huang ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Mr Imaging ◽  
Rat Model ◽  
Type I Collagen ◽  
Type I ◽  
Imaging Probe ◽  
Antifibrotic Therapy ◽  
Before And After ◽  
Targeted Mri

Fibrostenosis is a serious complication of Crohn’s disease (CD), affecting approximately one-half of all patients. Surgical resection is the typical clinical end due to ineffective antifibrotic therapy mainly through anti-inflammatory treatment and fibrosis can be reverted only at early stages. Mover, human fibrotic disorders is known to be associated with aging process. Thus, accurate monitoring of the progression of fibrosis is crucial for CD management as well as can be benefit to aging related fibrosis. The excessive deposition of type I collagen (ColI) is the core point in major complications of fibrosis, including that in patients with CD and aging related fibrosis. Therefore, a MR imaging probe (EP-3533) targeted ColI was employed to stage bowel fibrosis in CD using a rat model and to compare its efficiency with the common MR imaging contrast medium gadopentetatedimeglumine (Gd-DTPA). The bowel fibrotic rat model was established with different degrees of bowel fibrosis, were scanned using a 3.0-T MRI scanner with a specialized animal coil. MRI sequence including T1 mapping and T1-weighed imaging were performed before and after injecting the MRI probe (EP-3533 or Gd-DTPA). The T1 relaxation time (T1 value) and change in the contrast-to-noise ratio (ΔCNR) were measured to evaluate bowel fibrosis. Masson’s trichrome staining was performed to determine the severity of fibrosis. EP-3533 offered a better longitudinal relaxivity (r1) with 67.537 L/mmol·s, which was approximately 13 times that of Gd-DTPA. The T1 value on bowel segments was reduced in the images from EP-3533 compared to that from Gd-DTPA (F = 16.478; p &lt; 0.001). Additionally, a better correlation between ΔCNR calculated from EP-3533 imaging and bowel fibrosis (AUC = 0.846) was determined 10 min after enhanced media administration than with Gd-DTPA (AUC = 0.532). The 10th-minute ΔCNR performed using the ColI probe showed the best correlation with the severity of bowel fibrosis (r = 0.538; p = 0.021). Our results demonstrates that targeted MRI probe (EP-3533) supplies a better enhanced effect compared to Gd-DTPA and could be a promising method to evaluate the progression and monitor the therapeutic response of bowel fibrosis.

Prediction of Esophageal Retention: A Study Comparing High-Resolution Manometry and Functional Luminal Imaging Probe Panometry

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Dustin A. Carlson ◽  
Alexandra J. Baumann ◽  
Jacqueline E. Prescott ◽  
Jacob M. Schauer ◽  
Amanda Krause ◽  
...  
Keyword(s):  
High Resolution ◽  
Imaging Probe ◽  
High Resolution Manometry ◽  
Functional Luminal Imaging Probe
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