Microstructural white matter brain abnormalities in patients with idiopathic fecal incontinence

2017 ◽  
Vol 30 (1) ◽  
pp. e13164
Author(s):  
J. Muthulingam ◽  
S. Haas ◽  
T. M. Hansen ◽  
S. Laurberg ◽  
L. Lundby ◽  
...  
Keyword(s):  
White Matter ◽  
Fecal Incontinence ◽  
Brain Abnormalities ◽  
Idiopathic Fecal Incontinence

Anal Submucosal Carbon Bead Injection for Treatment of Idiopathic Fecal Incontinence

2009 ◽  
Vol 52 (2) ◽  
pp. 293-298 ◽  
Author(s):  
Felix Aigner ◽  
Friedrich Conrad ◽  
Raimund Margreiter ◽  
Michael Oberwalder
Keyword(s):  
Fecal Incontinence ◽  
Idiopathic Fecal Incontinence ◽  
Bead Injection

scholarly journals Longitudinal change of small-vessel disease-related brain abnormalities

2015 ◽  
Vol 36 (1) ◽  
pp. 26-39 ◽  
Author(s):  
Reinhold Schmidt ◽  
Stephan Seiler ◽  
Marisa Loitfelder
Keyword(s):  
White Matter ◽  
Treatment Effects ◽  
Small Vessel Disease ◽  
Surrogate Marker ◽  
White Matter Lesions ◽  
Surrogate Endpoint ◽  
Longitudinal Change ◽  
Small Vessel ◽  
Brain Abnormalities ◽  
Vessel Disease

Knowledge about the longitudinal change of cerebral small-vessel disease–related magnetic resonance imaging abnormalities increases our pathophysiologic understanding of cerebral microangiopathy. The change of specific lesion types may also serve as secondary surrogate endpoint in clinical trials. A surrogate endpoint needs to progress fast enough to allow monitoring of treatment effects within a reasonable time period, and change of the brain abnormality needs to be correlated with clinical change. Confluent white matter lesions show fast progression and correlations with cognitive decline. Thus, the change of confluent white matter lesions may be used as a surrogate marker in proof-of-concept trials with small patient numbers needed to show treatment effects on lesion progression. Nonetheless if the expected change in cognitive performance resulting from treatment effects on lesion progression is used as outcome, the sample size needed to show small to moderate treatment effects becomes very large. Lacunes may also fulfill the prerequisites of a surrogate marker, but in the general population the incidence of lacunes over short observational periods is small. For other small-vessel disease–related brain abnormalities including microbleeds and microstructural changes in normal-appearing white matter longitudinal change and correlations with clinical decline is not yet fully determined.

The importance of anal endosonography in the evaluation of idiopathic fecal incontinence

1994 ◽  
Vol 37 (1) ◽  
pp. 42-48 ◽  
Author(s):  
Ragnhild Emblem ◽  
Gonda Dhaenens ◽  
Ragnar Stien ◽  
Lars Mørkrid ◽  
Ansgar O. Aasen ◽  
...  
Keyword(s):  
Fecal Incontinence ◽  
Anal Endosonography ◽  
Idiopathic Fecal Incontinence

Pudendal nerve function in idiopathic fecal incontinence

2000 ◽  
Vol 43 (5) ◽  
pp. 633-636 ◽  
Author(s):  
Ole Ø. Rasmussen ◽  
John Christiansen ◽  
Tine Tetzschner ◽  
Michael Sørensen
Keyword(s):  
Fecal Incontinence ◽  
Pudendal Nerve ◽  
Nerve Function ◽  
Idiopathic Fecal Incontinence

The relationship of pudendal nerve terminal motor latency to squeeze pressure in patients with idiopathic fecal incontinence

2001 ◽  
Vol 44 (5) ◽  
pp. 666-671 ◽  
Author(s):  
B.Ó C. Súilleabháin ◽  
A. F. Horgan ◽  
L. McEnroe ◽  
F. W. Poon ◽  
J. H. Anderson ◽  
...  
Keyword(s):  
Fecal Incontinence ◽  
Nerve Terminal ◽  
Pudendal Nerve ◽  
Squeeze Pressure ◽  
Motor Latency ◽  
Idiopathic Fecal Incontinence ◽  
Relationship Of ◽  
The Relationship

Abnormal neuronal response to rectal and anal stimuli in patients with idiopathic fecal incontinence

2015 ◽  
Vol 27 (7) ◽  
pp. 954-962 ◽  
Author(s):  
S. Haas ◽  
C. Brock ◽  
K. Krogh ◽  
M. Gram ◽  
L. Lundby ◽  
...  
Keyword(s):  
Fecal Incontinence ◽  
Neuronal Response ◽  
Idiopathic Fecal Incontinence

scholarly journals Structural brain abnormalities associated with deletion at chromosome 22q11

2001 ◽  
Vol 178 (5) ◽  
pp. 412-419 ◽  
Author(s):  
Therese Van Amelsvoort ◽  
Eileen Daly ◽  
Dene Robertson ◽  
John Suckling ◽  
Virginia Ng ◽  
...  
Keyword(s):  
White Matter ◽  
Learning Disability ◽  
Brain Anatomy ◽  
White Matter Volume ◽  
Brain Abnormalities ◽  
Temporal Lobes ◽  
Chromosome 22Q11 ◽  
High Prevalence ◽  
Velo Cardio Facial Syndrome ◽  
Regional Brain Volume

BackgroundVelo-cardio-facial syndrome (VCFS) is associated with deletions in the q11 band of chromosome 22, learning disability and psychosis, but the neurobiological basis is poorly understood.AimsTo investigate brain anatomy in adults with VCFS.MethodMagnetic resonance imaging was used to study 10 patients with VCFS and 13 matched controls. We carried out three analyses: qualitative; traced regional brain volume; and measurement of grey and white matter volume.ResultsThe subjects with VCFS had: a high prevalence of white matter hyperintensities and abnormalities of the septum pellucidum; a significantly smaller volume of cerebellum; and widespread differences in white matter bilaterally and regional specific differences in grey matter in the left cerebellum, insula, and frontal and right temporal lobes.ConclusionsDeletion at chromosome 22q11 is associated with brain abnormalities that are most likely neurodevelopmental and may partially explain the high prevalence of learning disability and psychiatric disorder in VCFS.

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