scholarly journals Colonic content in health and its relation to functional gut symptoms

2016 ◽  
Vol 28 (6) ◽  
pp. 849-854 ◽  
Author(s):  
R. A. Bendezú ◽  
E. Barba ◽  
E. Burri ◽  
D. Cisternas ◽  
A. Accarino ◽  
...  
Keyword(s):  
Colonic Content

scholarly journals Botulism (type A) in a horse - case report

2016 ◽  
Vol 85 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Sevim Kasap ◽  
Hasan Batmaz ◽  
Meric Kocaturk ◽  
Frank Gessler ◽  
Serkan Catık ◽  
...  
Keyword(s):  
Botulinum Neurotoxin ◽  
Clinical Signs ◽  
Type A ◽  
Serum Samples ◽  
Specific Antibodies ◽  
Thoroughbred Horse ◽  
Botulinum Neurotoxin Type A ◽  
Botulinum Neurotoxins ◽  
First Time ◽  
Colonic Content

This paper presents the case of a six year-old, male, thoroughbred horse with clinical signs of inappetence, weakness, and incoordination when walking. Clinical examination showed that the horse staggered and leaned to the left side. Feedstuff was present inside and around its mouth. Salivation was increased and there was no reflex at the palpebrae and tongue. The horse had difficulty swallowing and the tone of its tail was reduced. Botulism was diagnosed based on the clinical signs. Antibiotic (ceftiofur) and fluid-electrolyte treatment was commenced. Next day, neostigmin was added to the horse’s treatment, and it became recumbent. The horse’s palpebral, tongue and tail reflexes returned partially after neostigmine methylsulphate treatment on the same day and it stood up on day four. However, it could not swallow anything during the whole week, so after getting permission from the owner, the horse was euthanized on day 10. Samples of the colonic content and blood serum were sent by courier to the laboratory for toxin neutralization, however, botulinum neurotoxins could not be detected. After that, serum samples from days 6 and 10 were sent to another laboratory for testing for botulinum neurotoxin antibodies by ELISA. Specific antibodies against botulinum neurotoxin type A were measured, indicating a previous, immuno-relevant contact with the toxin. This seroconversion for type A supports the clinical botulism diagnosis. Type A botulism is rarely seen in Europe and has been detected in a horse in Turkey for the first time.

scholarly journals Possible role of colonic content in the mucosal association of pathogenic shigella

1980 ◽  
Vol 29 (3) ◽  
pp. 1197-1199
Author(s):  
R Prizont ◽  
W P Reed
Keyword(s):  
Shigella Flexneri ◽  
Colonic Content

Association of Shigella flexneri to cecal membrances was studied by incubating the pathogen with cecal slices of germfree mice. The slices were first incubated with stool supernatants from germfree, shigella-monocontaminated, and conventional animals. Quantitation of shigellae in homogenates of treated slices revealed an increase of organisms only in those slices exposed to contaminated stool supernatants.

scholarly journals Microprocessor-controlled movement of solid colonic content using sequential neural electrical stimulation

2001 ◽  
Vol 120 (5) ◽  
pp. A108
Author(s):  
Manuel A. Amaris ◽  
Peter Z. Rashev ◽  
Martin P. Mintchev ◽  
Kenneth L. Bowes
Keyword(s):  
Electrical Stimulation ◽  
Colonic Content

scholarly journals Colonic content: effect of diet, meals, and defecation

2016 ◽  
Vol 29 (2) ◽  
pp. e12930 ◽  
Author(s):  
R. A. Bendezú ◽  
M. Mego ◽  
E. Monclus ◽  
X. Merino ◽  
A. Accarino ◽  
...  
Keyword(s):  
Colonic Content

scholarly journals Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Åsa Håkansson ◽  
Camilla Bränning ◽  
Göran Molin ◽  
Diya Adawi ◽  
Marie-Louise Hagslätt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colonic Mucosa ◽  
Clinical Situation ◽  
Viable Count ◽  
Malignant Potential ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Colonic Tumour ◽  
Altered Liver ◽  
Colonic Content

Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count ofEnterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.

scholarly journals Microprocessor-controlled movement of solid colonic content using sequential neural electrical stimulation

2001 ◽  
Vol 120 (5) ◽  
pp. A108-A108
Author(s):  
M AMARIS ◽  
P RASHEV ◽  
M MINTCHEV ◽  
K BOWES
Keyword(s):  
Electrical Stimulation ◽  
Colonic Content

scholarly journals Differential Effects of Western and Mediterranean-Type Diets on Gut Microbiota: A Metagenomics and Metabolomics Approach

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2638
Author(s):  
Claudia Barber ◽  
Marianela Mego ◽  
Carlos Sabater ◽  
Fernando Vallejo ◽  
Rogger Alvaro Bendezu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mediterranean Diet ◽  
Urinary Metabolites ◽  
Microbial Metabolism ◽  
Randomised Study ◽  
Metabolic Functions ◽  
Faecal Samples ◽  
Metabolite Profiles ◽  
Diet Versus ◽  
Colonic Content

Our aim was to determine the effect of diet on gut microbiota, digestive function and sensations, using an integrated clinical, metagenomics and metabolomics approach. We conducted a cross-over, randomised study on the effects of a Western-type diet versus a fibre-enriched Mediterranean diet. In 20 healthy men, each diet was administered for 2 weeks preceded by a 2-week washout diet. The following outcomes were recorded: (a) number of anal gas evacuations; (b) digestive sensations; (c) volume of gas evacuated after a probe meal; (d) colonic content by magnetic resonance imaging; (e) gut microbiota taxonomy and metabolic functions by shotgun sequencing of faecal samples; (f) urinary metabolites using untargeted metabolomics. As compared to a Western diet, the Mediterranean diet was associated with (i) higher number of anal gas evacuations, (ii) sensation of flatulence and borborygmi, (iii) larger volume of gas after the meal and (iv) larger colonic content. Despite the relatively little difference in microbiota composition between both diets, microbial metabolism differed substantially, as shown by urinary metabolite profiles and the abundance of microbial metabolic pathways. The effects of the diet were less evident in individuals with robust microbiotas (higher beta-diversity). To conclude, healthy individuals tolerate dietary changes with minor microbial modifications at the composition level but with remarkable variation in microbial metabolism.

scholarly journals Studies on the Pathogenesis of Swine Dysentery

1979 ◽  
Vol 16 (5) ◽  
pp. 567-573 ◽  
Author(s):  
B. P. Wilcock ◽  
H. J. Olander
Keyword(s):  
Light Microscopy ◽  
Cell Cultures ◽  
Live Cells ◽  
Morphologic Change ◽  
Swine Dysentery ◽  
Visible Effect ◽  
Treponema Hyodysenteriae ◽  
Colonic Content

Broth cultures of Treponema hyodysenteriae and colonic content from pigs with swine dysentery were tested for cytotoxicity in cell cultures, erythrocyte suspensions and in ligated segments of pig colon. Live cells of T. hyodysenteriae attached to the surface of cells in all cultures tested but did not penetrate them nor cause morphologic change detectable by light microscopy. Only live T. hyodysenteriae caused erythrolysis. Broth cultures or colonic content sterilized by filtration or by disruption with ultrasound had no visible effect on the cell cultures, erythrocyte suspensions or the mucosa of ligated colonic segments.

scholarly journals Heterogeneous colonic content: A prenatal sonographic manifestation of lysinuric protein intolerance

2020 ◽  
Vol 8 (6) ◽  
pp. 1010-1014
Author(s):  
Christos Dimitriou ◽  
Souha Saliba ◽  
Xavier Peyrassol ◽  
Wafa Ben Abbou ◽  
Marie Cécile Nassogne ◽  
...  
Keyword(s):  
Lysinuric Protein Intolerance ◽  
Lysinuric Protein ◽  
Protein Intolerance ◽  
Colonic Content

scholarly journals Changes in Microbiota and Bacterial Protein Caseinolytic Peptidase B During Food Restriction in Mice: Relevance for the Onset and Perpetuation of Anorexia Nervosa

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2514 ◽  
Author(s):  
Manon Dominique ◽  
Romain Legrand ◽  
Marie Galmiche ◽  
Saïda Azhar ◽  
Camille Deroissart ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Plasma Concentration ◽  
Associated Factors ◽  
Food Access ◽  
Food Restriction ◽  
Bacterial Protein ◽  
Limited Food ◽  
Access To Food ◽  
Colonic Content

Microbiota contributes to the regulation of eating behavior and might be implicated in the pathophysiology of anorexia nervosa. ClpB (Caseinolytic peptidase B) protein produced mainly by the Enterobacteriaceae family has been identified as a conformational mimetic of α-MSH, which could result in similar anorexigenic effects. The aim of this study was to highlight the role of the microbiome and the ClpB protein in deregulation and self-maintenance of anorexia pathology. Male C57Bl/6 mice were undergone to the ABA (Activity-Based Anorexia) protocol: after 5 days of acclimatization, both ABA and LFA (Limited Food Access) mice had progressively limited access to food until D17. At the end of protocol, the plasma ClpB concentration and Enterobacteriaceae DNA in colonic content were measured. As expected, dietary restriction induced lost weight in LFA and ABA mice. At D10, colonic permeability and plasma concentration of the ClpB protein were significantly increased in LFA and ABA mice vs. controls. At D17, plasma concentration of ClpB was increased in LFA and ABA mice and, it was correlated with proportion of Enterobacteriaceae in the faeces. These abnormally high ClpB concentrations and all associated factors, and therefore might contribute to the initiation and/or perpetuation of anorexia nervosa by interfering with satiety signaling.

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