scholarly journals Colorectal Oncogenesis and Inflammation in a Rat Model Based on Chronic Inflammation due to Cycling DSS Treatments

2011 ◽  
Vol 2011 ◽  
pp. 1-15 ◽  
Author(s):  
Åsa Håkansson ◽  
Camilla Bränning ◽  
Göran Molin ◽  
Diya Adawi ◽  
Marie-Louise Hagslätt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colonic Mucosa ◽  
Clinical Situation ◽  
Viable Count ◽  
Malignant Potential ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Colonic Tumour ◽  
Altered Liver ◽  
Colonic Content

Inflammation is known to be linked with development of colorectal cancer, and the aim was to assess the malignant potential and degree of inflammation in a dextran-sulphate-sodium-(DSS-) induced cyclic colonic tumour model (CTM) in rats and to compare it with the azoxymethane-(AOM-) induced CTM model. Tumours developed in both groups, although, in the DSS group, the colonic mucosa appeared edematous and the number of haemorrhagic erosions and quantity of dysplastic lesions were higher as well as the mucosal concentration of myeloperoxidase and faecal viable count ofEnterobacteriaceae. The livers were affected as evaluated by steatosis, parenchymal loss, haemorrhage, and inflammatory infiltrations, and higher proportions of acetate and lower proportions of butyrate in colonic content were found. The DSS model seems to mimic the clinical situation and may be valuable for investigation of inflammation-related dysplasia and colon cancer, as well as for altered liver function by endogenous inflammatory mediators.

A new flavonoid derivative, dosmalfate, attenuates the development of dextran sulphate sodium-induced colitis in mice

2003 ◽  
Vol 3 (13-14) ◽  
pp. 1731-1741 ◽  
Author(s):  
Isabel Villegas ◽  
Catalina Alarcón de la Lastra ◽  
Aurelio Orjales ◽  
Carmen La Casa
Keyword(s):  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

Impact of dextran sulphate sodium-induced colitis on the intestinal transport of the colon carcinogen PhIP

2015 ◽  
Vol 90 (5) ◽  
pp. 1093-1102 ◽  
Author(s):  
Petra Nicken ◽  
Anne von Keutz ◽  
Ina Willenberg ◽  
Annika I. Ostermann ◽  
Nils Helge Schebb ◽  
...  
Keyword(s):  
Intestinal Transport ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium

Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer

2009 ◽  
Vol 27 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Paul Salama ◽  
Michael Phillips ◽  
Fabienne Grieu ◽  
Melinda Morris ◽  
Nik Zeps ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colonic Mucosa ◽  
Tumor Tissue ◽  
Early Stage ◽  
Prognostic Significance ◽  
High Density ◽  
Prognostic Indicators ◽  
Normal Colonic Mucosa ◽  
Solid Cancer ◽  
Histopathologic Features

Purpose To determine the prognostic significance of FOXP3+ lymphocyte (Treg) density in colorectal cancer compared with conventional histopathologic features and with CD8+ and CD45RO+ lymphocyte densities. Patients and Methods Tissue microarrays and immunohistochemistry were used to assess the densities of CD8+, CD45RO+, and FOXP3+ lymphocytes in tumor tissue and normal colonic mucosa from 967 stage II and stage III colorectal cancers. These were evaluated for associations with histopathologic features and patient survival. Results FOXP3+ Treg density was higher in tumor tissue compared with normal colonic mucosa, whereas CD8+ and CD45RO+ cell densities were lower. FOXP3+ Tregs were not associated with any histopathologic features, with the exception of tumor stage. Multivariate analysis showed that stage, vascular invasion, and FOXP3+ Treg density in normal and tumor tissue were independent prognostic indicators, but not CD8+ and CD45RO+. High FOXP3+ Treg density in normal mucosa was associated with worse prognosis (hazard ratio [HR] = 1.51; 95% CI, 1.07 to 2.13; P = .019). In contrast, a high density of FOXP3+ Tregs in tumor tissue was associated with improved survival (HR = 0.54; 95% CI, 0.38 to 0.77; P = .001). Conclusion FOXP3+ Treg density in normal and tumor tissue had stronger prognostic significance in colorectal cancer compared with CD8+ and CD45RO+ lymphocytes. The finding of improved survival associated with a high density of tumor-infiltrating FOXP3+ Tregs in colorectal cancer contrasts with several other solid cancer types. The inclusion of FOXP3+ Treg density may help to improve the prognostication of early-stage colorectal cancer.

Stevioside, a diterpenoid glycoside, shows anti-inflammatory property against Dextran Sulphate Sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 855 ◽  
pp. 192-201 ◽  
Author(s):  
Sateesh Alavala ◽  
Rajendra Sangaraju ◽  
Nasiruddin Nalban ◽  
Bidya Dhar Sahu ◽  
Mahesh Kumar Jerald ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulphate ◽  
Dextran Sulphate Sodium ◽  
Anti Inflammatory

scholarly journals Artificial intelligence assisted standard white light endoscopy accurately characters early colorectal cancer: a multicenter diagnostic study

2020 ◽  
Author(s):  
Sijun Meng ◽  
Yueping Zheng ◽  
Ruizhang Su ◽  
Wangyue Wang ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Colorectal Cancer ◽  
Malignant Potential ◽  
Early Colorectal Cancer ◽  
Diagnostic Study ◽  
Internal Validation ◽  
White Light Endoscopy ◽  
Incidence And Mortality ◽  
Validation Set ◽  
Screening And Prevention

ABSTRACTColorectal cancer (CRC) is the third in incidence and mortality1 of cancer. Screening with colonoscopy has been shown to reduce mortality by 40-60%2. Challenge for screening indistinguishable precancerous and noninvasive lesion using conventional colonoscopy was still existing3. We propose to establish a propagable artificial intelligence assisted high malignant potential early CRC characterization system (ECRC-CAD). 4,390 endoscopic images of early CRC were used to establish the model. The diagnostic accuracy of high malignant potential early CRC was 0.963 (95% CI, 0.941-0.978) in the internal validation set and 0.835 (95% CI, 0.805-0.862) in external datasets. It achieved better performance than the expert endoscopists. Spreading of ECRC-CAD to regions with different medical levels can assist in CRC screening and prevention.

Dietary Petitvert supplementation protects against acute colitis induced by dextran sulphate sodium in mice

2014 ◽  
Vol 2 (3) ◽  
pp. 103-104
Author(s):  
A. Somasundaram ◽  
A.T. Rajarajan ◽  
P. Vigneshwaran ◽  
K. Vengadeshprabhu ◽  
H. Meilei ◽  
...  
Keyword(s):  
Dextran Sulphate ◽  
Acute Colitis ◽  
Dextran Sulphate Sodium

scholarly journals Claudin-3 Overexpression Increases the Malignant Potential of Colorectal Cancer Cells: Roles of ERK1/2 and PI3K-Akt as Modulators of EGFR signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74994 ◽  
Author(s):  
Waldemir F. de Souza ◽  
Natalia Fortunato-Miranda ◽  
Bruno K. Robbs ◽  
Wallace M. de Araujo ◽  
Julio C. de-Freitas-Junior ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Malignant Potential ◽  
Egfr Signaling ◽  
Colorectal Cancer Cells
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