The role of theSCN5A-encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders

2015 ◽  
Vol 27 (7) ◽  
pp. 906-913 ◽  
Author(s):  
T. E. Verstraelen ◽  
R. M. A. ter Bekke ◽  
P. G. A. Volders ◽  
A. A. M. Masclee ◽  
J. W. Kruimel
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Disorders ◽  
Irritable Bowel

scholarly journals The Role of Mast Cells in Irritable Bowel Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Kang Nyeong Lee ◽  
Oh Young Lee
Keyword(s):  
Irritable Bowel Syndrome ◽  
Mast Cells ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Future Directions ◽  
Intestinal Dysmotility ◽  
Immune Alterations ◽  
Irritable Bowel ◽  
And Function

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders, but its treatment is unsatisfactory as its pathophysiology is multifactorial. The putative factors of IBS pathophysiology are visceral hypersensitivity and intestinal dysmotility, also including psychological factors, dysregulated gut-brain axis, intestinal microbiota alterations, impaired intestinal permeability, and mucosal immune alterations. Recently, mucosal immune alterations have received much attention with the role of mast cells in IBS. Mast cells are abundant in the intestines and function as intestinal gatekeepers at the interface between the luminal environment in the intestine and the internal milieu under the intestinal epithelium. As a gatekeeper at the interface, mast cells communicate with the adjacent cells such as epithelial, neuronal, and other immune cells throughout the mediators released when they themselves are activated. Many studies have suggested that mast cells play a role in the pathophysiology of IBS. This review will focus on studies of the role of mast cell in IBS and the limitations of studies and will also consider future directions.

scholarly journals The gut microbiome and irritable bowel syndrome

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1029 ◽  
Author(s):  
Stacy Menees ◽  
William Chey
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiome ◽  
Bacterial Communities ◽  
Functional Gastrointestinal Disorders ◽  
Gastrointestinal Disorders ◽  
Gut Dysbiosis ◽  
Downstream Effects ◽  
Gut Immune System ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders encountered in clinical practice. It is a heterogeneous disorder with a multifactorial pathogenesis. Recent studies have demonstrated that an imbalance in gut bacterial communities, or “dysbiosis”, may be a contributor to the pathophysiology of IBS. There is evidence to suggest that gut dysbiosis may lead to activation of the gut immune system with downstream effects on a variety of other factors of potential relevance to the pathophysiology of IBS. This review will highlight the data addressing the emerging role of the gut microbiome in the pathogenesis of IBS and review the evidence for current and future microbiome based treatments

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

2012 ◽  
Vol 303 (7) ◽  
pp. G775-G785 ◽  
Author(s):  
Michael Camilleri ◽  
Karen Lasch ◽  
Wen Zhou
Keyword(s):  
Irritable Bowel Syndrome ◽  
Immune Responses ◽  
Tight Junctions ◽  
The Body ◽  
Gastrointestinal Disorders ◽  
Mucosal Permeability ◽  
The Past ◽  
Afferent Nerves ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal ailments among those seeking health care for gastrointestinal disorders. Despite its prevalence, IBS pathophysiology is still not completely understood. Continued elucidation of IBS etiological mechanisms will lead to a greater appreciation of possible therapeutic targets. In the past decade, there has been increasing focus on the possible connection between increased intestinal mucosal permeability, inflammation, and visceral hypersensitivity. Increased permeability in subsets of IBS patients has been observed and the possible mechanisms underlying this defect are just beginning to be understood. The objectives of this review are to summarize the role of the healthy intestinal epithelium as a barrier between the lumen and the rest of the body with a focus on tight junctions; to examine the lines of evidence that suggest that different triggers lead to increased intestinal mucosal permeability and disruption of tight junctions in IBS patients; and to explore how this increased permeability may elicit immune responses that affect afferent nerves, resulting in the pain associated with IBS.

The role of intestinal microbiota in the development of urolithiasis in patients with an irritable bowel syndrome

2020 ◽  
Vol 0 (3) ◽  
pp. 29-36
Author(s):  
I. A. Derkach ◽  
A. E. Dorofeyev ◽  
M. M. Rudenko ◽  
G. A. Dorofeyeva ◽  
Yu. Z. Dynia
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Irritable Bowel

Review: The Role of MOP and DOP Receptors in Treatment of Diarrheapredominant Irritable Bowel Syndrome

2016 ◽  
Vol 16 (18) ◽  
pp. 1462-1469 ◽  
Author(s):  
Agata Jarmu| ◽  
Marta Zieli|ska ◽  
Karolina Le| ◽  
Martyna Banaszek ◽  
Martin Storr ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Irritable Bowel

Gut dysbiosis and irritable bowel syndrome: The potential role of probiotics

2018 ◽  
Vol 76 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Nicola Principi ◽  
Rita Cozzali ◽  
Edoardo Farinelli ◽  
Andrea Brusaferro ◽  
Susanna Esposito
Keyword(s):  
Irritable Bowel Syndrome ◽  
Potential Role ◽  
Gut Dysbiosis ◽  
Irritable Bowel

NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64208-64214 ◽  
Author(s):  
Shenglan Yang ◽  
Danfang Deng ◽  
Yingying Luo ◽  
Yanran Wu ◽  
Rui Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Irritable Bowel Syndrome ◽  
Hydrogen Sulfide ◽  
Murine Model ◽  
Irritable Bowel ◽  
And Oxidative Stress ◽  
Post Infectious

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.

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