Are there sex differences in placebo analgesia during visceral pain processing? A fMRI study in healthy subjects

2014 ◽  
Vol 26 (12) ◽  
pp. 1743-1753 ◽  
Author(s):  
N. Theysohn ◽  
J. Schmid ◽  
A. Icenhour ◽  
C. Mewes ◽  
M. Forsting ◽  
...  
Keyword(s):  
Sex Differences ◽  
Healthy Subjects ◽  
Visceral Pain ◽  
Pain Processing ◽  
Placebo Analgesia ◽  
Fmri Study

S1807 Cognitive Coping Mechanism of Limbic/Paralimbic System in the Modulation of Placebo Analgesia in Visceral Pain: A 3t-fMRI Study

2008 ◽  
Vol 134 (4) ◽  
pp. A-273-A-274
Author(s):  
Hsueh-Chieh Lu ◽  
Ching-Liang Lu ◽  
David M. Niddam ◽  
Jen-Chuen Hsieh ◽  
Full-Young Chang ◽  
...  
Keyword(s):  
Visceral Pain ◽  
Coping Mechanism ◽  
Cognitive Coping ◽  
Placebo Analgesia ◽  
Fmri Study ◽  
Paralimbic System

scholarly journals Sex differences in brain response to anticipated and experienced visceral pain in healthy subjects

2013 ◽  
Vol 304 (8) ◽  
pp. G687-G699 ◽  
Author(s):  
Michiko Kano ◽  
Adam D. Farmer ◽  
Qasim Aziz ◽  
Vincent P. Giampietro ◽  
Michael J. Brammer ◽  
...  
Keyword(s):  
Sex Differences ◽  
Healthy Subjects ◽  
Visceral Pain ◽  
Premotor Cortex ◽  
Functional Gastrointestinal Disorders ◽  
Group Analysis ◽  
Midcingulate Cortex ◽  
Significant Difference ◽  
Anxiety Levels ◽  
Brain Processing

Women demonstrate higher pain sensitivity and prevalence of chronic visceral pain conditions such as functional gastrointestinal disorders than men. The role of sex differences in the brain processing of visceral pain is still unclear. In 16 male and 16 female healthy subjects we compared personality, anxiety levels, skin conductance response (SCR), and brain processing using functional MRI during anticipation and pain induced by esophageal distension at pain toleration level. There was no significant difference in personality scores, anxiety levels, SCR, and subjective ratings of pain between sexes. In group analysis, both men and women demonstrated a similar pattern of brain activation and deactivation during anticipation and pain consistent with previous reports. However, during anticipation women showed significantly greater activation in the cuneus, precuneus, and supplementary motor area (SMA) and stronger deactivation in the right amygdala and left parahippocampal gyrus, whereas men demonstrated greater activation in the cerebellum. During pain, women demonstrated greater activation in the midcingulate cortex, anterior insula, premotor cortex, and cerebellum and stronger deactivation in the caudate, whereas men showed increased activity in the SMA. The pattern of brain activity suggests that, during anticipation, women may demonstrate stronger limbic inhibition, which is considered to be a cognitive modulation strategy for impending painful stimulation. During pain, women significantly activate brain areas associated with the affective and motivation components of pain. These responses may underlie the sex differences that exist in pain conditions, whereby women may attribute more emotional importance to painful stimuli compared with men.

Neural Mechanisms Mediating Placebo Analgesia in Visceral Pain: An FMRI Study in Placebo Responders and Non-Responders

2011 ◽  
Vol 140 (5) ◽  
pp. S-56 ◽  
Author(s):  
Sigrid Elsenbruch ◽  
Vassilios Kotsis ◽  
Sven Benson ◽  
Daniel Reidick ◽  
Christina Rosenberger ◽  
...  
Keyword(s):  
Visceral Pain ◽  
Neural Mechanisms ◽  
Placebo Analgesia ◽  
Fmri Study

Su2097 Conditioning and Extinction Learning of Visceral Pain in Healthy Subjects - An FMRI Study

2013 ◽  
Vol 144 (5) ◽  
pp. S-556
Author(s):  
Michiko Kano ◽  
Steven J. Coen ◽  
Adam D. Farmer ◽  
Vincent Gampietro ◽  
Michael J. Brammer ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Visceral Pain ◽  
Extinction Learning ◽  
Fmri Study

Su1967 Gender Differences in Brain Activity During Visceral Placebo Analgesia in Healthy Subjects

2012 ◽  
Vol 142 (5) ◽  
pp. S-548
Author(s):  
I-Ju Lin ◽  
Ching-Liang Lu ◽  
Jen-Chuen Hsieh ◽  
Full-Young Chang
Keyword(s):  
Gender Differences ◽  
Healthy Subjects ◽  
Brain Activity ◽  
Placebo Analgesia

Neuronal correlates in the modulation of placebo analgesia in experimentally-induced esophageal pain: A 3T-fMRI study

Pain ◽  
2010 ◽  
Vol 148 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Hsueh-Chieh Lu ◽  
Jen-Chuen Hsieh ◽  
Ching-Liang Lu ◽  
David M. Niddam ◽  
Yu-Te Wu ◽  
...  
Keyword(s):  
Placebo Analgesia ◽  
Fmri Study ◽  
Experimentally Induced

scholarly journals Polarity-specific modulation of pain processing by transcranial direct current stimulation – a blinded longitudinal fMRI study

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Steffen Naegel ◽  
Josephine Biermann ◽  
Nina Theysohn ◽  
Christoph Kleinschnitz ◽  
Hans-Christoph Diener ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Pain Processing ◽  
Direct Current Stimulation ◽  
Fmri Study
Sign in / Sign up

Export Citation Format

Share Document