Sex Differences in the Duration of the P Wave in Healthy Subjects

Cardiology ◽  
1968 ◽  
Vol 53 (1) ◽  
pp. 47-50
Author(s):  
D. Gross
2013 ◽  
Vol 304 (8) ◽  
pp. G687-G699 ◽  
Author(s):  
Michiko Kano ◽  
Adam D. Farmer ◽  
Qasim Aziz ◽  
Vincent P. Giampietro ◽  
Michael J. Brammer ◽  
...  

Women demonstrate higher pain sensitivity and prevalence of chronic visceral pain conditions such as functional gastrointestinal disorders than men. The role of sex differences in the brain processing of visceral pain is still unclear. In 16 male and 16 female healthy subjects we compared personality, anxiety levels, skin conductance response (SCR), and brain processing using functional MRI during anticipation and pain induced by esophageal distension at pain toleration level. There was no significant difference in personality scores, anxiety levels, SCR, and subjective ratings of pain between sexes. In group analysis, both men and women demonstrated a similar pattern of brain activation and deactivation during anticipation and pain consistent with previous reports. However, during anticipation women showed significantly greater activation in the cuneus, precuneus, and supplementary motor area (SMA) and stronger deactivation in the right amygdala and left parahippocampal gyrus, whereas men demonstrated greater activation in the cerebellum. During pain, women demonstrated greater activation in the midcingulate cortex, anterior insula, premotor cortex, and cerebellum and stronger deactivation in the caudate, whereas men showed increased activity in the SMA. The pattern of brain activity suggests that, during anticipation, women may demonstrate stronger limbic inhibition, which is considered to be a cognitive modulation strategy for impending painful stimulation. During pain, women significantly activate brain areas associated with the affective and motivation components of pain. These responses may underlie the sex differences that exist in pain conditions, whereby women may attribute more emotional importance to painful stimuli compared with men.


2002 ◽  
Vol 35 (4) ◽  
pp. 307-311 ◽  
Author(s):  
Sedat Kose ◽  
Kudret Aytemir ◽  
Ilknur Can ◽  
Atilla Iyisoy ◽  
Ayhan Kilic ◽  
...  

2021 ◽  
Author(s):  
Shin-ichiro Seno ◽  
Hideaki Shimazu ◽  
Eiki Kogure ◽  
Atsushi Watanabe ◽  
Hiroko Kobayashi

Abstract Objective This study aimed to measure the current perception threshold (CPT) of five fingertips of the left hand in healthy subjects and analyze whether sex differences in perception thresholds are suppressed when adjusting for fingertip size among males and females. Results For fingertips from the thumb to the little finger, the males’ CPT values were 1.03, 0.83, 0.86, 0.86, and 0.88 mA; the females’ results were 0.63, 0.55, 0.54, 0.51, and 0.50 mA. The CPTs were higher in males than in females for every fingertip. Upon adjusting for fingertip length, the log-transformed CPT values were found to have sex differences, except for the index finger: thumb, t(20.05) = 3.493, p = 0.002; middle finger, U(30) = 44.50, p = 0.005; ring finger, t(30) = 55.50, p = 0.018; little finger, U(30) = 30.00, p = 0.001. Similarly, the CPT values, transformed into log values when adjusting for the fingertip area, were found to have sex differences for three fingertips: thumb, t(18) = 2.649, p = 0.016; middle finger, U(20) = 12.00, p = 0.004; ring finger, t(18) = 2.206, p = 0.041. According to this study, sex differences in CPTs were not completely abolished by adjusting for fingertip length or area.


Diagnostics ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 946
Author(s):  
Matteo Cameli ◽  
Marcelo Haertel Miglioranza ◽  
Julien Magne ◽  
Giulia Elena Mandoli ◽  
Giovanni Benfari ◽  
...  

Two methods are currently available for left atrial (LA) strain measurement by speckle tracking echocardiography, with two different reference timings for starting the analysis: QRS (QRS-LASr) and P wave (P-LASr). The aim of MASCOT HIT study was to define which of the two was more reproducible, more feasible, and less time consuming. In 26 expert centers, LA strain was analyzed by two different echocardiographers (young vs senior) in a blinded fashion. The study population included: healthy subjects, patients with arterial hypertension or aortic stenosis (LA pressure overload, group 2) and patients with mitral regurgitation or heart failure (LA volume–pressure overload, group 3). Difference between the inter-correlation coefficient (ICC) by the two echocardiographers using the two techniques, feasibility and analysis time of both methods were analyzed. A total of 938 subjects were included: 309 controls, 333 patients in group 2, and 296 patients in group 3. The ICC was comparable between QRS-LASr (0.93) and P-LASr (0.90). The young echocardiographers calculated QRS-LASr in 90% of cases, the expert ones in 95%. The feasibility of P-LASr was 85% by young echocardiographers and 88% by senior ones. QRS-LASr young median time was 110 s (interquartile range, IR, 78-149) vs senior 110 s (IR 78-155); for P-LASr, 120 s (IR 80-165) and 120 s (IR 90-161), respectively. LA strain was feasible in the majority of patients with similar reproducibility for both methods. QRS complex guaranteed a slightly higher feasibility and a lower time wasting compared to the use of P wave as the reference.


2002 ◽  
Vol 52 (7) ◽  
pp. 759-763 ◽  
Author(s):  
Aki Laakso ◽  
Harry Vilkman ◽  
J.örgen Bergman ◽  
Merja Haaparanta ◽  
Olof Solin ◽  
...  

2017 ◽  
Vol 52 (6) ◽  
pp. 585-595 ◽  
Author(s):  
Itziar Montalvo ◽  
Roser Nadal ◽  
Antonio Armario ◽  
Alfonso Gutiérrez-Zotes ◽  
Marta Creus ◽  
...  

Introduction: Hyperprolactinaemia is commonly observed in people with psychotic disorders due to D2 receptor blockade by antipsychotic drugs, although it may also exist in drug-naïve patients with first-episode psychosis. Recent studies suggest that hyperprolactinaemia may have a negative impact on cognitive function in people with early psychosis. We aimed to explore whether there are sex differences in the association between prolactin levels and cognitive performance in early psychosis patients. Methods: We studied 60 young patients with early psychosis (aged 18–35 years, 35% females) and a sex- and age-matched control group of 50 healthy subjects. Cognitive assessment was performed with the MATRICS Consensus Cognitive Battery. Prolactin, total cortisol, follicular-stimulating hormone, luteal hormone and sex steroids (testosterone in men, oestradiol and progesterone in women) were measured in plasma. Salivary cortisol was measured at different sampling times (awakening response, 10:00 and 23:00). Psychopathological status was assessed, and antipsychotic treatment was registered. Multiple linear regression analyses were used to explore the relationship between prolactin and cognitive tasks while adjusting for covariates. Results: Prolactin levels were associated with impaired processing speed in men, and this association was independent of cortisol and testosterone. In women, prolactin levels were not associated with processing speed tasks, although we observed a negative effect of prolactin on verbal learning and spatial working memory in female healthy subjects. The male-dependent effect maintained its significance after adjusting for education status, antipsychotic treatment and negative symptoms. Conclusion: Our study demonstrates that the previously reported association between high prolactin levels and impaired cognitive processes in early psychosis is restricted to men.


2007 ◽  
Vol 7 (1) ◽  
Author(s):  
Rasmus Havmoller ◽  
Jonas Carlson ◽  
Fredrik Holmqvist ◽  
Alberto Herreros ◽  
Carl J Meurling ◽  
...  

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