scholarly journals Ventilator hyperinflation determined by peak airway pressure delivered: A randomized crossover trial

2020 ◽  
Author(s):  
Wendy Jacob ◽  
Diane Dennis ◽  
Angela Jacques ◽  
Lisa Marsh ◽  
Paul Woods ◽  
...  
Keyword(s):  
Airway Pressure ◽  
Crossover Trial ◽  
Peak Airway Pressure ◽  
Randomized Crossover Trial

scholarly journals Expiratory Positive Airway Pressure for Sleep Apnea after Stroke: A Randomized, Crossover Trial

2016 ◽  
Vol 12 (09) ◽  
pp. 1233-1238 ◽  
Author(s):  
Natalie C. Wheeler ◽  
Jeffrey J. Wing ◽  
Louise M. O'Brien ◽  
Rebecca Hughes ◽  
Teresa Jacobs ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Airway Pressure ◽  
Crossover Trial ◽  
Positive Airway Pressure ◽  
Randomized Crossover Trial ◽  
Expiratory Positive Airway Pressure

scholarly journals Cardiorespiratory effects of NIV-NAVA, NIPPV, and NCPAP shortly after extubation in extremely preterm infants: a randomized crossover trial

2021 ◽  
Author(s):  
Samantha Latremouille ◽  
Monica Bhuller ◽  
Wissam Shalish ◽  
Guilherme Sant'Anna
Keyword(s):  
Airway Pressure ◽  
Crossover Trial ◽  
Mode Analysis ◽  
Positive Pressure ◽  
Neurally Adjusted Ventilatory Assist ◽  
Full Data ◽  
Non Invasive ◽  
Randomized Crossover Trial ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Objective: Investigate the cardiorespiratory effects of non-invasive neurally adjusted ventilatory assist (NIV-NAVA), non-synchronized nasal intermittent positive pressure ventilation (NIPPV), and nasal continuous positive airway pressure (NCPAP) during the critical period shortly after extubation. Hypothesis: Levels of non-invasive pressure support provided and/or presence of synchronization can affect cardiorespiratory parameters. Study design: Randomized crossover trial. Patient-subject selection: Infants with birth weight (BW) ≤ 1250g undergoing their first planned extubation were randomly assigned to all 3 modes following extubation. Methodology: Electrocardiogram and electrical activity of the diaphragm (Edi) were recorded during 30min on each mode. Analysis of heart rate variability (HRV), diaphragmatic activity (Edi area, breath area, amplitude, inspiratory and expiratory times) and respiratory variability (RV) were compared between modes. Results: 23 enrolled infants had full data recordings and analysis: median [IQR] gestational age = 25.9 weeks [25.2-26.4], BW = 760g [595-900], and post-natal age 7 [4-19] days. There were no differences in HRV parameters between modes. During NIV-NAVA and NIPPV, diaphragmatic activity was significantly lower and RV higher than NCPAP. Delivered peak inflation pressures (PIPs) were lower during NIV-NAVA than NIPPV (14 cmH2O [13-16] vs cmH2O 16 [16-17]; p<0.001). However, due to a significantly higher proportion of assisted breaths (99% [92-103] vs. 51% [38-82]; p<0.001) NIV-NAVA provided a higher mean airway pressure (MAP)(9.4 cmH2O [8.2-10.0] vs. 8.2 cmH2O [7.6-9.3]; p=0.002). Conclusions: NIV-NAVA and NIPPV applied shortly after extubation were associated with positive cardiorespiratory effects. This effect was more evident during NIV-NAVA where patient-ventilator synchronization provided a higher MAP with lower PIPs.

Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial

2021 ◽  
Vol 17 (2) ◽  
pp. 189-196
Author(s):  
Cláudia Silva Schindel ◽  
Daniele Schiwe ◽  
João Paulo Heinzmann-Filho ◽  
Natália Evangelista Campos ◽  
Paulo Márcio Pitrez ◽  
...  
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Crossover Trial ◽  
Positive Airway Pressure ◽  
Exercise Duration ◽  
Randomized Crossover Trial

scholarly journals Effects of Pressure Control Device (SensAwake™) on Obstructive Sleep Apnea (OSA) Patients Who Remove the Mask for Unknown Reasons during Automatic Continuous Positive Airway Pressure (Auto-CPAP) Therapy: A Prospective Randomized Crossover Trial

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 915
Author(s):  
Yen-Lung Chen ◽  
Li-Pang Chuang ◽  
Shih-Wei Lin ◽  
Hung-Yu Huang ◽  
Geng-Hao Liu ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Sleep Quality ◽  
Airway Pressure ◽  
Crossover Trial ◽  
Positive Airway Pressure ◽  
Cpap Therapy ◽  
Randomized Crossover Trial ◽  
Obstructive Sleep

Backgroundand Objectives: Obstructive sleep apnea (OSA) patients may remove their mask unconsciously during automatic continuous positive airway pressure (Auto-CPAP) therapy and therefore cannot receive good treatment. The discomfort from the airflow of Auto-CPAP may be one reason for interrupted sleep. Sens Awake (SA) can detect the arousal and lower the pressure to prevent patients from fully awakening from sleep. Materials and Methods: To evaluate the effect of SA, we designed a prospective, randomized, crossover trial comparing Auto-CPAP with and without SA on Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), Nasal Obstruction Symptom Evaluation (NOSE) Scale and recorded data from the auto-CPAP machine. Results: In the 25 patients who completed the study, the gender, age, body mass index, neck circumference, polysomnography data, and previous CPAP use were not significantly different between the two arms. The average and 90th percentile pressures were significantly lower during SA on (SA on vs. off: 6.9 ± 2.7 vs. 7.3 ± 2.6 [p = 0.032] and 8.6 ± 3.0 vs. 9.2 ± 2.9 [p = 0.002], respectively). The time used, days used, compliance, average and 90th percentile leaks, and the residual Apnea-Hypopnea Index (AHI) were not significantly changed between the SA on-and-off. Based on the subjective evaluation, PSQI, ESS, and NOSE were not significantly different between the SA on-and-off; however, based on additional analyses which were compared with baseline data, the ESS was significantly lower when the SA was on (SA on vs. baseline: 11.1 ± 6.1 vs. 13.2 ± 6.0 [p = 0.023]). Conclusions: CPAP therapy with or without two weeks of the SA had a similar effect on CPAP use, sleep quality, daytime sleepiness, and nasal obstruction. The SA may have a tendency to improve daytime sleepiness, but needs further study with a longer duration of treatment.

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