Intracranial myxoid angiomatoid fibrous histiocytoma with “classic” histology and EWSR1:CREM fusion providing insight for reconciliation with intracranial myxoid mesenchymal tumors

2021 ◽  
Author(s):  
Nicholas J.H. Tan ◽  
Patricia Diana Pratiseyo ◽  
Eka J. Wahjoepramono ◽  
Chik Hong Kuick ◽  
Jian Yuan Goh ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Mesenchymal Tumors ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Intracranial myxoid mesenchymal tumors with EWSR1 -CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?

2017 ◽  
Vol 28 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Tejus A. Bale ◽  
Angelica Oviedo ◽  
Harry Kozakewich ◽  
Caterina Giannini ◽  
Phani K. Davineni ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Gene Fusions ◽  
Mesenchymal Tumors ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Family Gene

Angiomatoid Fibrous Histiocytoma

2016 ◽  
Vol 78 (3) ◽  
pp. 219-220
Author(s):  
Yoshihiko Inoue ◽  
Shiho Terawaki ◽  
Kazuko Imamura ◽  
Yumiko Kubota ◽  
Masazumi Tsuneyoshi ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Aneurysmal ("angiomatoid") fibrous histiocytoma in a child

1989 ◽  
Vol 4 (4) ◽  
pp. 159 ◽  
Author(s):  
Chong Jai Kim ◽  
Jung Hee Cho ◽  
Je Geun Chi
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma

Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology

2013 ◽  
Vol 67 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Yu-Chien Kao ◽  
Jui Lan ◽  
Hui-Chun Tai ◽  
Chien-Feng Li ◽  
Kai-Wen Liu ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Molecular Characterisation ◽  
Angiomatoid Fibrous Histiocytoma

Angiomatoid Fibrous Histiocytoma in an HIV-positive Child

2008 ◽  
Vol 30 (3) ◽  
pp. 242-244 ◽  
Author(s):  
Laura Martelli ◽  
Paola Collini ◽  
Cristina Meazza ◽  
Alessandra Bianchi ◽  
Filippo Salvini ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Hiv Positive ◽  
Angiomatoid Fibrous Histiocytoma

Immunohistochemical Expression of Matrix Metalloproteinases 1, 2, 9, and 14 in Dermatofibrosarcoma Protuberans and Common Fibrous Histiocytoma (Dermatofibroma)

2004 ◽  
Vol 128 (10) ◽  
pp. 1136-1141 ◽  
Author(s):  
David M. Weinrach ◽  
Kim L. Wang ◽  
Elizabeth L. Wiley ◽  
William B. Laskin
Keyword(s):  
Matrix Metalloproteinases ◽  
Tumor Cells ◽  
Fibrous Histiocytoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Growth Patterns ◽  
Dermal Fibroblasts ◽  
Major Constituent ◽  
Mesenchymal Tumors ◽  
Formalin Fixed Paraffin Embedded ◽  
Immunohistochemical Studies

Abstract Context.—Common fibrous histiocytoma (cFH) or dermatofibroma and dermatofibrosarcoma protuberans (DFSP) are 2 spindle cell mesenchymal tumors that are distinguished in part by their microscopic growth patterns and clinically by the greater propensity for DFSP to recur. Matrix metalloproteinases (MMPs) potentially play a role in modulating the growth patterns of cFH and DFSP by remodeling the extracellular matrix. Objective.—To evaluate the immunohistochemical (IHC) expression of MMP-1, MMP-2, MMP-9, and MMP-14 in DFSP and cFH, because (1) MMP-1, MMP-2, MMP-9, and MMP-14 are synthesized by dermal fibroblasts, the major constituent of DFSP and cFH; and (2) platelet-derived growth factor B, which is overexpressed in most examples of DFSP because of t(17;22), activates ets-1, a transcription factor that regulates molecules associated with tumor invasion and metastasis, including MMP-1, MMP-3, and MMP-9. Design.—Immunohistochemical studies were performed on archived, formalin-fixed, paraffin-embedded tissue of DFSP (n = 48) and cFH (n = 47). Results.—Significant IHC expression (>10% of tumor cells) in cFH included MMP-14 (27 [59%] of 46 tumors positive), MMP-2 (21 [47%] of 45 tumors positive), MMP-9 (9 [20%] of 45 tumors positive), and MMP-1 (6 [13%] of 46 tumors positive). No DFSPs showed significant IHC expression of any of the MMPs evaluated. However, anti– MMP-2 highlighted a rich microvascular element within deep tumor tissue present in 81% of DFSPs with a prominent subcutaneous component. Conclusion.—Our IHC results indicate that MMP-1 and MMP-9 are not up-regulated in DFSP. Convincing expression of MMP-14 in cFH suggests that this MMP may affect the growth pattern of the lesion, perhaps by activating MMP-2 expression in tumor cells. In DFSP, MMP-2 may play a role in tumor angiogenesis.

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