scholarly journals Intracranial mesenchymal tumor with FET‐CREB fusion – a unifying diagnosis for the spectrum of intracranial myxoid mesenchymal tumors and angiomatoid fibrous histiocytoma‐like neoplasms

2020 ◽  
Author(s):  
Emily A. Sloan ◽  
Jason Chiang ◽  
Javier E. Villanueva‐Meyer ◽  
Sanda Alexandrescu ◽  
Jennifer M. Eschbacher ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Mesenchymal Tumor ◽  
Mesenchymal Tumors ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Intracranial myxoid mesenchymal tumors with EWSR1 -CREB family gene fusions: myxoid variant of angiomatoid fibrous histiocytoma or novel entity?

2017 ◽  
Vol 28 (2) ◽  
pp. 183-191 ◽  
Author(s):  
Tejus A. Bale ◽  
Angelica Oviedo ◽  
Harry Kozakewich ◽  
Caterina Giannini ◽  
Phani K. Davineni ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Gene Fusions ◽  
Mesenchymal Tumors ◽  
Angiomatoid Fibrous Histiocytoma ◽  
Family Gene

Angiomatoid Fibrous Histiocytoma

2016 ◽  
Vol 78 (3) ◽  
pp. 219-220
Author(s):  
Yoshihiko Inoue ◽  
Shiho Terawaki ◽  
Kazuko Imamura ◽  
Yumiko Kubota ◽  
Masazumi Tsuneyoshi ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals Aneurysmal ("angiomatoid") fibrous histiocytoma in a child

1989 ◽  
Vol 4 (4) ◽  
pp. 159 ◽  
Author(s):  
Chong Jai Kim ◽  
Jung Hee Cho ◽  
Je Geun Chi
Keyword(s):  
Fibrous Histiocytoma ◽  
Angiomatoid Fibrous Histiocytoma

scholarly journals SURG-35. INTRACRANIAL MYXOID MESENCHYMAL TUMOR WITH EWSR1-ATF1 GENE FUSION

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii210-ii211
Author(s):  
Benjamin Ward ◽  
Christopher Wang ◽  
Rob Macaulay ◽  
James Liu
Keyword(s):  
Radiation Therapy ◽  
Gene Fusion ◽  
Histological Analysis ◽  
Treatment Plan ◽  
Mesenchymal Tumor ◽  
Tumor Control ◽  
Adjuvant Radiation ◽  
Middle Aged ◽  
Mesenchymal Tumors ◽  
Middle Aged Adult

Abstract Intracranial myxoid mesenchymal tumors (IMMT) carrying an EWSR1-CREB gene family fusion are extremely rare and have only been identified in ten relatively recent reported cases. There is some question as to whether this is a novel entity, or a myxoid variant of angiomatoid fibrous histiocytoma (AFH), given certain histopathological similarities. Despite these similarities, the increasing number of cases reported appear to demonstrate clear histological differences that indicate IMMTs are a distinct and novel entity. Previous reports have focused on histological analysis but have lacked detailed long-term clinical follow-up and recommendations regarding treatment approach. In this case, we describe a 48-year-old female who presented with a left intraventricular mass that was identified histologically as an IMMT with an EWSR1-ATF1 gene fusion. Following initial resection, the tumor demonstrated local recurrence. Repeat resection was performed followed by immediate demonstration of local, as well as distant, tumor recurrence. Subsequent histological analysis of the tumor demonstrated a myxoid mesenchymal tumor clearly distinct from AFH. Fractionated stereotactic radiation therapy was administered following the second resection and tumor control was achieved at 1 year. This case is particularly remarkable as it is only the second reported IMMT case to occur in a middle-aged adult, with all other cases occurring in children or young adults. The two middle-aged adult cases share striking similarities in clinical presentation, including a history of breast cancer. Our findings indicate that an intracranial myxoid mesenchymal tumor is a novel and rare entity that may demonstrate rapid local and distant recurrence. Given the aggressive recurrence seen with the presented case, we recommend the treatment plan to be surgical resection followed by adjuvant radiation therapy to maintain tumor control.

Angiomatoid fibrous histiocytoma: clinicopathological and molecular characterisation with emphasis on variant histomorphology

2013 ◽  
Vol 67 (3) ◽  
pp. 210-215 ◽  
Author(s):  
Yu-Chien Kao ◽  
Jui Lan ◽  
Hui-Chun Tai ◽  
Chien-Feng Li ◽  
Kai-Wen Liu ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Molecular Characterisation ◽  
Angiomatoid Fibrous Histiocytoma

Angiomatoid Fibrous Histiocytoma in an HIV-positive Child

2008 ◽  
Vol 30 (3) ◽  
pp. 242-244 ◽  
Author(s):  
Laura Martelli ◽  
Paola Collini ◽  
Cristina Meazza ◽  
Alessandra Bianchi ◽  
Filippo Salvini ◽  
...  
Keyword(s):  
Fibrous Histiocytoma ◽  
Hiv Positive ◽  
Angiomatoid Fibrous Histiocytoma

Immunohistochemical Expression of Matrix Metalloproteinases 1, 2, 9, and 14 in Dermatofibrosarcoma Protuberans and Common Fibrous Histiocytoma (Dermatofibroma)

2004 ◽  
Vol 128 (10) ◽  
pp. 1136-1141 ◽  
Author(s):  
David M. Weinrach ◽  
Kim L. Wang ◽  
Elizabeth L. Wiley ◽  
William B. Laskin
Keyword(s):  
Matrix Metalloproteinases ◽  
Tumor Cells ◽  
Fibrous Histiocytoma ◽  
Dermatofibrosarcoma Protuberans ◽  
Growth Patterns ◽  
Dermal Fibroblasts ◽  
Major Constituent ◽  
Mesenchymal Tumors ◽  
Formalin Fixed Paraffin Embedded ◽  
Immunohistochemical Studies

Abstract Context.—Common fibrous histiocytoma (cFH) or dermatofibroma and dermatofibrosarcoma protuberans (DFSP) are 2 spindle cell mesenchymal tumors that are distinguished in part by their microscopic growth patterns and clinically by the greater propensity for DFSP to recur. Matrix metalloproteinases (MMPs) potentially play a role in modulating the growth patterns of cFH and DFSP by remodeling the extracellular matrix. Objective.—To evaluate the immunohistochemical (IHC) expression of MMP-1, MMP-2, MMP-9, and MMP-14 in DFSP and cFH, because (1) MMP-1, MMP-2, MMP-9, and MMP-14 are synthesized by dermal fibroblasts, the major constituent of DFSP and cFH; and (2) platelet-derived growth factor B, which is overexpressed in most examples of DFSP because of t(17;22), activates ets-1, a transcription factor that regulates molecules associated with tumor invasion and metastasis, including MMP-1, MMP-3, and MMP-9. Design.—Immunohistochemical studies were performed on archived, formalin-fixed, paraffin-embedded tissue of DFSP (n = 48) and cFH (n = 47). Results.—Significant IHC expression (>10% of tumor cells) in cFH included MMP-14 (27 [59%] of 46 tumors positive), MMP-2 (21 [47%] of 45 tumors positive), MMP-9 (9 [20%] of 45 tumors positive), and MMP-1 (6 [13%] of 46 tumors positive). No DFSPs showed significant IHC expression of any of the MMPs evaluated. However, anti– MMP-2 highlighted a rich microvascular element within deep tumor tissue present in 81% of DFSPs with a prominent subcutaneous component. Conclusion.—Our IHC results indicate that MMP-1 and MMP-9 are not up-regulated in DFSP. Convincing expression of MMP-14 in cFH suggests that this MMP may affect the growth pattern of the lesion, perhaps by activating MMP-2 expression in tumor cells. In DFSP, MMP-2 may play a role in tumor angiogenesis.

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