Coexistence of mixed phenotype Creutzfeldt-Jakob disease, Lewy body disease and argyrophilic grain disease plus histological features of possible Alzheimer's disease: A multi-protein disorder in an autopsy case

2014 ◽  
Vol 35 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Iván Fernández-Vega ◽  
Javier Ruiz-Ojeda ◽  
Ramon A. Juste ◽  
Maria Geijo ◽  
Juan Jose Zarranz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Lewy Body ◽  
Lewy Body Disease ◽  
Protein Disorder ◽  
Autopsy Case ◽  
Histological Features ◽  
Argyrophilic Grain Disease ◽  
Jakob Disease ◽  
Argyrophilic Grain ◽  
Mixed Phenotype

scholarly journals Structural connectivity networks in Alzheimer’s disease and Lewy body disease

2021 ◽  
Author(s):  
Kyoungwon Baik ◽  
Jin‐Ju Yang ◽  
Jin Ho Jung ◽  
Yang Hyun Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Structural Connectivity ◽  
Lewy Body Disease

scholarly journals Argyrophilic grain disease: An underestimated tauopathy

2015 ◽  
Vol 9 (1) ◽  
pp. 2-8 ◽  
Author(s):  
Roberta Diehl Rodriguez ◽  
Lea Tenenholz Grinberg
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Defense Mechanism ◽  
Neuropsychiatric Symptoms ◽  
Argyrophilic Grain Disease ◽  
Coiled Bodies ◽  
Pathologic Features ◽  
High Prevalence ◽  
Argyrophilic Grain ◽  
Argyrophilic Grains

Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer's disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer's disease. This review aims to provide an in-depth overview of the current understanding on AGD.

scholarly journals Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer’s disease and neocortical Lewy body disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
János Bencze ◽  
Máté Szarka ◽  
Viktor Bencs ◽  
Renáta Nóra Szabó ◽  
Máté Smajda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tyrosine Kinase ◽  
Lewy Body ◽  
Lewy Body Disease ◽  
Cortical Layer ◽  
Cellular Processes ◽  
Tyrosine Kinase 2 ◽  
Post Mortem Brain ◽  
Significant Difference

AbstractAlzheimer’s disease (AD) and neocortical Lewy body disease (LBD) are the most common neurodegenerative dementias, with no available curative treatment. Elucidating pathomechanism and identifying novel therapeutic targets are of paramount importance. Lemur tyrosine kinase 2 (LMTK2) is involved in several physiological and pathological cellular processes. Herewith a neuropathological characterization is presented in AD and neocortical LBD samples using chromogenic and fluorescent LMTK2 immunohistochemistry on post-mortem brain tissues and compared them to age-matched controls (CNTs). LMTK2 immunopositivity was limited to the neuronal cytoplasm. Neurons, including tau-positive tangle-bearing ones, showed decreased chromogenic and immunofluorescent labelling in AD in every cortical layer compared to CNT and neocortical LBD. Digital image analysis was performed to measure the average immunopositivity of groups. Mean grey values were calculated for each group after measuring the grey scale LMTK2 signal intensity of each individual neuron. There was significant difference between the mean grey values of CNT vs. AD and neocortical LBD vs. AD. The moderate decrease in neocortical LBD suggests the effect of coexisting AD pathology. We provide neuropathological evidence on decreased neuronal LMTK2 immunolabelling in AD, with implications for pathogenesis.

scholarly journals Effects of Alzheimer's disease and Lewy body disease on subcortical atrophy

2019 ◽  
Vol 27 (2) ◽  
pp. 318-326 ◽  
Author(s):  
H. S. Yoo ◽  
E. C. Lee ◽  
S. J. Chung ◽  
Y. H. Lee ◽  
S. G. Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Disease

scholarly journals Inflammation in mild cognitive impairment due to Parkinson's disease, Lewy body disease, and Alzheimer's disease

2019 ◽  
Vol 34 (8) ◽  
pp. 1244-1250 ◽  
Author(s):  
Eleanor King ◽  
John O'Brien ◽  
Paul Donaghy ◽  
Caroline H. Williams-Gray ◽  
Rachael A. Lawson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lewy Body ◽  
Lewy Body Disease
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