Different patterns of hippocampal subfield pathology in Lewy body disease and Alzheimer's disease

2021 ◽  
Author(s):  
Kurt A. Jellinger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Disease

scholarly journals Structural connectivity networks in Alzheimer’s disease and Lewy body disease

2021 ◽  
Author(s):  
Kyoungwon Baik ◽  
Jin‐Ju Yang ◽  
Jin Ho Jung ◽  
Yang Hyun Lee ◽  
Seok Jong Chung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Structural Connectivity ◽  
Lewy Body Disease

scholarly journals Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer’s disease and neocortical Lewy body disease

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
János Bencze ◽  
Máté Szarka ◽  
Viktor Bencs ◽  
Renáta Nóra Szabó ◽  
Máté Smajda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Tyrosine Kinase ◽  
Lewy Body ◽  
Lewy Body Disease ◽  
Cortical Layer ◽  
Cellular Processes ◽  
Tyrosine Kinase 2 ◽  
Post Mortem Brain ◽  
Significant Difference

AbstractAlzheimer’s disease (AD) and neocortical Lewy body disease (LBD) are the most common neurodegenerative dementias, with no available curative treatment. Elucidating pathomechanism and identifying novel therapeutic targets are of paramount importance. Lemur tyrosine kinase 2 (LMTK2) is involved in several physiological and pathological cellular processes. Herewith a neuropathological characterization is presented in AD and neocortical LBD samples using chromogenic and fluorescent LMTK2 immunohistochemistry on post-mortem brain tissues and compared them to age-matched controls (CNTs). LMTK2 immunopositivity was limited to the neuronal cytoplasm. Neurons, including tau-positive tangle-bearing ones, showed decreased chromogenic and immunofluorescent labelling in AD in every cortical layer compared to CNT and neocortical LBD. Digital image analysis was performed to measure the average immunopositivity of groups. Mean grey values were calculated for each group after measuring the grey scale LMTK2 signal intensity of each individual neuron. There was significant difference between the mean grey values of CNT vs. AD and neocortical LBD vs. AD. The moderate decrease in neocortical LBD suggests the effect of coexisting AD pathology. We provide neuropathological evidence on decreased neuronal LMTK2 immunolabelling in AD, with implications for pathogenesis.

scholarly journals Effects of Alzheimer's disease and Lewy body disease on subcortical atrophy

2019 ◽  
Vol 27 (2) ◽  
pp. 318-326 ◽  
Author(s):  
H. S. Yoo ◽  
E. C. Lee ◽  
S. J. Chung ◽  
Y. H. Lee ◽  
S. G. Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Lewy Body ◽  
Lewy Body Disease

scholarly journals Inflammation in mild cognitive impairment due to Parkinson's disease, Lewy body disease, and Alzheimer's disease

2019 ◽  
Vol 34 (8) ◽  
pp. 1244-1250 ◽  
Author(s):  
Eleanor King ◽  
John O'Brien ◽  
Paul Donaghy ◽  
Caroline H. Williams-Gray ◽  
Rachael A. Lawson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Lewy Body ◽  
Lewy Body Disease

EFFECT OF LEWY BODY DISEASE AND ALZHEIMER’S DISEASE ON COGNITION AND BRAIN ATROPHY

2017 ◽  
Vol 13 (7) ◽  
pp. P1526-P1527
Author(s):  
Sungwoo Kang ◽  
Seun Jeon ◽  
Mijin Yun ◽  
Byoung Seok Ye
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Atrophy ◽  
Lewy Body ◽  
Lewy Body Disease
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