Deep Brain Stimulation of the Internal Pallidum in Lesch–Nyhan Syndrome: Clinical Outcomes and Connectivity Analysis

2020 ◽  
Author(s):  
Kantharuby Tambirajoo ◽  
Luciano Furlanetti ◽  
Harutomo Hasegawa ◽  
Ahmed Raslan ◽  
Hortensia Gimeno ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Clinical Outcomes ◽  
Brain Stimulation ◽  
Connectivity Analysis ◽  
Internal Pallidum ◽  
Deep Brain ◽  
Stimulation Of

scholarly journals Deep brain stimulation modulates directional limbic connectivity in obsessive-compulsive disorder

Brain ◽  
2020 ◽  
Vol 143 (5) ◽  
pp. 1603-1612 ◽  
Author(s):  
Egill Axfjord Fridgeirsson ◽  
Martijn Figee ◽  
Judy Luigjes ◽  
Pepijn van den Munckhof ◽  
P Richard Schuurman ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Internal Capsule ◽  
Connectivity Analysis ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Impact ◽  
Deep Brain ◽  
Stimulation Of

Abstract Deep brain stimulation is effective for patients with treatment-refractory obsessive-compulsive disorder. Deep brain stimulation of the ventral anterior limb of the internal capsule rapidly improves mood and anxiety with optimal stimulation parameters. To understand these rapid effects, we studied functional interactions within the affective amygdala circuit. We compared resting state functional MRI data during chronic stimulation versus 1 week of stimulation discontinuation in patients, and obtained two resting state scans from matched healthy volunteers to account for test-retest effects. Imaging data were analysed using functional connectivity analysis and dynamic causal modelling. Improvement in mood and anxiety following deep brain stimulation was associated with reduced amygdala-insula functional connectivity. Directional connectivity analysis revealed that deep brain stimulation increased the impact of the ventromedial prefrontal cortex on the amygdala, and decreased the impact of the amygdala on the insula. These results highlight the importance of the amygdala circuit in the pathophysiology of obsessive-compulsive disorder, and suggest a neural systems model through which negative mood and anxiety are modulated by stimulation of the ventral anterior limb of the internal capsule for obsessive-compulsive disorder and possibly other psychiatric disorders.

Deep brain stimulation of the internal pallidum in multiple system atrophy

2006 ◽  
Vol 12 (3) ◽  
pp. 181-183 ◽  
Author(s):  
Santens Patrick ◽  
Vonck Kristl ◽  
De Letter Miet ◽  
Van Driessche Katya ◽  
Sieben Anne ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Multiple System Atrophy ◽  
Brain Stimulation ◽  
Internal Pallidum ◽  
Deep Brain ◽  
Stimulation Of

Corrigendum to “Deep brain stimulation of the internal pallidum in multiple system atrophy”

2007 ◽  
Vol 13 (1) ◽  
pp. 63
Author(s):  
P. Santens ◽  
K. Vonck ◽  
M. De Letter ◽  
K. Van Driessche ◽  
A. Sieben ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Multiple System Atrophy ◽  
Brain Stimulation ◽  
Internal Pallidum ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation of the internal pallidum did not improve chorea in a patient with neuro-acanthocytosis

2001 ◽  
Vol 16 (3) ◽  
pp. 572-575 ◽  
Author(s):  
G. Wihl ◽  
J. Volkmann ◽  
N. Allert ◽  
R. Lehrke ◽  
V. Sturm ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Internal Pallidum ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation of the internal pallidum in Huntington’s disease patients: clinical outcome and neuronal firing patterns

2015 ◽  
Vol 263 (2) ◽  
pp. 290-298 ◽  
Author(s):  
Cécile Delorme ◽  
Alister Rogers ◽  
Brian Lau ◽  
Hélène Francisque ◽  
Marie-Laure Welter ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Clinical Outcome ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Brain Stimulation ◽  
Neuronal Firing ◽  
Firing Patterns ◽  
Internal Pallidum ◽  
Deep Brain ◽  
Stimulation Of
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