scholarly journals Functional and Structural Connectivity Patterns Associated with Clinical Outcomes in Deep Brain Stimulation of the Globus Pallidus Internus for Generalized Dystonia

2020 ◽  
Vol 41 (3) ◽  
pp. 508-514 ◽  
Author(s):  
L. Okromelidze ◽  
T. Tsuboi ◽  
R.S. Eisinger ◽  
M.R. Burns ◽  
M. Charbel ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Clinical Outcomes ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Structural Connectivity ◽  
Globus Pallidus Internus ◽  
Connectivity Patterns ◽  
Generalized Dystonia ◽  
Deep Brain ◽  
Stimulation Of

Serial 1H-MRS of thalamus during deep brain stimulation of bilateral globus pallidus internus for primary generalized dystonia

2008 ◽  
Vol 50 (12) ◽  
pp. 1055-1059 ◽  
Author(s):  
Mikhail F. Chernov ◽  
Taku Ochiai ◽  
Takaomi Taira ◽  
Yuko Ono ◽  
Ryoichi Nakamura ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Globus Pallidus Internus ◽  
1H Mrs ◽  
Generalized Dystonia ◽  
Deep Brain ◽  
Stimulation Of

Treatment of Persistent Hemiballism with Deep Brain Stimulation of the Globus Pallidus Internus: Case Report and Literature Review

2019 ◽  
Vol 132 ◽  
pp. 368-370
Author(s):  
Somnath V. Ganapa ◽  
Margish D. Ramani ◽  
Oladotun O. Ebunlomo ◽  
Raphia K. Rahman ◽  
Yehuda Herschman ◽  
...  
Keyword(s):  
Case Report ◽  
Deep Brain Stimulation ◽  
Literature Review ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Globus Pallidus Internus ◽  
Deep Brain ◽  
Stimulation Of

Treatment of idiopathic head drop (camptocephalia) by deep brain stimulation of the globus pallidus internus

2009 ◽  
Vol 110 (6) ◽  
pp. 1271-1273 ◽  
Author(s):  
Damianos E. Sakas ◽  
Ioannis G. Panourias ◽  
Efstathios J. Boviatsis ◽  
Marios S. Themistocleous ◽  
Lambis C. Stavrinou ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Globus Pallidus Internus ◽  
Number Of Patients ◽  
Chronic Electrical Stimulation ◽  
Lying Down ◽  
Deep Brain ◽  
Stimulation Of

Deep brain stimulation of the globus pallidus internus has been shown to be beneficial in a small number of patients suffering from axial dystonias. However, it has not yet been reported as an effective treatment for the alleviation of idiopathic head drop. The authors describe a 49-year-old woman with idiopathic cervical dystonia (camptocephalia) who was unable to raise her head > 30° when standing or sitting; her symptoms would abate when lying down. This disabling neurological condition was treated successfully with bilateral chronic electrical stimulation of the globus pallidus internus.

Successful bilateral deep brain stimulation of the globus pallidus internus for persistent status dystonicus and generalized chorea

2010 ◽  
Vol 113 (3) ◽  
pp. 634-638 ◽  
Author(s):  
Diana Apetauerova ◽  
Clemens M. Schirmer ◽  
Jay L. Shils ◽  
Janet Zani ◽  
Jeffrey E. Arle
Keyword(s):  
Deep Brain Stimulation ◽  
Movement Disorder ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Globus Pallidus Internus ◽  
Battery Life ◽  
Status Dystonicus ◽  
Hyperkinetic Movement Disorder ◽  
Deep Brain ◽  
Stimulation Of

The authors report the cases of 2 young male patients (aged 16 and 26 years) with dystonic cerebral palsy of unknown origin, who developed status dystonicus, an acute and persistent combination of generalized dystonia and chorea. Both patients developed status dystonicus after undergoing general anesthesia, and in 1 case, after administration of metoclopramide. In attempting to control this acute hyperkinetic movement disorder, multiple medication trials failed in both cases and patients required prolonged intubation and sedation with propofol. Bilateral deep brain stimulation of the globus pallidus internus (4 and 2 months after the onset of symptoms in the first and second case, respectively) produced immediate resolution of the hyperkinetic movement disorder in each case. Deep brain stimulation provided persistent suppression of the dystonic movement potential after a follow-up of 30 and 34 months, respectively, as demonstrated by the reemergence of severe dystonia during the end of battery life of the implantable pulse generators that was readily controlled by exchange of the generators in each case.

L-DOPA-INDUCED DYSKINESIA AND STEREOTACTIC SURGERY FOR PARKINSON'S DISEASE

Neurosurgery ◽  
2008 ◽  
Vol 62 (2) ◽  
pp. 311-325 ◽  
Author(s):  
Jorge Guridi ◽  
Jose A. Obeso ◽  
Maria C. Rodriguez-Oroz ◽  
Andres M. Lozano ◽  
Miguel Manrique
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Globus Pallidus Internus ◽  
The Impact ◽  
Deep Brain ◽  
Stimulation Of

Abstract OBJECTIVE To assess the impact of different surgical targets and techniques, such as ablation and deep brain stimulation, to treat patients with L-dopa-induced dyskinesia (LID), a major therapeutic complication of Parkinson's disease. METHODS This review analyzes the effects of early surgical procedures to treat hyperkinesia and the current methods and targets used to combat LID in Parkinson's disease, which are mainly thalamotomy, pallidotomy, and deep brain stimulation of the globus pallidus internus and the subthalamic nucleus. RESULTS Available information indicates that surgery of the globus pallidus internus and thalamus (the pallidal receiving area) and of the subthalamic nucleus has a pronounced antidyskinetic effect. This effect is associated with a concomitant improvement in the parkinsonian (“off”-medication) state. Although it is more profound with pallidal and subthalamic surgery, such an effect can also be observed to some extent with thalamic surgery. The latter is attributable to the fact that surgery of the ventralis intermedius is primarily effective for treating tremor. An integral pallidothalamic pathway is needed for dyskinesia to be expressed. Thus, LID is less frequent after subthalamotomy or deep brain stimulation of the subthalamic nucleus through a functional effect mediated by the physiological normalization of the motor system and by an indirect effect associated with a reduction in the daily dose of L-dopa. CONCLUSION Surgery is the only treatment available for Parkinson's disease that can predictably improve both the parkinsonian motor syndrome and LID. The exact mechanisms involved in these effects are not well understood. Pallidal and thalamic surgery affecting pallidal relays reduce LID frequency by disrupting the pallidothalamic circuit, probably eliminating the neuronal activity associated with dyskinesia. Alternatively, the antidyskinetic effect of subthalamic nucleus surgery may in part be attributable to a reduction in the L-dopa dose as well as to the stabilization of the basal ganglia circuits after the surgical procedure.

Bilateral deep brain stimulation of the globus pallidus internus in tardive dystonia

2008 ◽  
Vol 23 (13) ◽  
pp. 1929-1931 ◽  
Author(s):  
Wataru Sako ◽  
Satoshi Goto ◽  
Hideki Shimazu ◽  
Nagako Murase ◽  
Kazuhito Matsuzaki ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Globus Pallidus Internus ◽  
Tardive Dystonia ◽  
Deep Brain ◽  
Stimulation Of
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