Unilateral Stimulation of Prelemniscal Radiations for the Treatment of Acral Symptoms of Parkinson's Disease: Long-Term Results

2016 ◽  
Vol 19 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Francisco Velasco ◽  
José D. Carrillo-Ruiz ◽  
Víctor Salcido ◽  
Guillermo Castro ◽  
Julián Soto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results ◽  
Unilateral Stimulation ◽  
Stimulation Of

Stereotaxic cryosurgery in patients with Parkinson's disease. Long-term results

1997 ◽  
Vol 99 ◽  
pp. S160
Author(s):  
V. Tjumikov ◽  
A. Kadykov ◽  
V. Peresedov ◽  
A. Shirshov ◽  
E. Sungurov ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results

Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

2010 ◽  
Vol 25 (5) ◽  
pp. 578-586 ◽  
Author(s):  
Elena Moro ◽  
Andres M. Lozano ◽  
Pierre Pollak ◽  
Yves Agid ◽  
Stig Rehncrona ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multicenter Study ◽  
Long Term Results ◽  
Pallidal Stimulation

Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: long-term follow-up

2002 ◽  
Vol 23 (0) ◽  
pp. s111-s112 ◽  
Author(s):  
A. Tavella ◽  
B. Bergamasco ◽  
E. Bosticco ◽  
M. Lanotte ◽  
P. Perozzo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Long Term Follow Up ◽  
Deep Brain ◽  
Stimulation Of

Electrical Stimulation of the Prelemniscal Radiation in the Treatment of Parkinson's Disease: An Old Target Revised with New Techniques

Neurosurgery ◽  
2001 ◽  
Vol 49 (2) ◽  
pp. 293-308 ◽  
Author(s):  
Francisco Velasco ◽  
Fiacro Jiménez ◽  
Martha Luisa Pérez ◽  
José D. Carrillo-Ruiz ◽  
Ana Luisa Velasco ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Electrical Stimulation ◽  
Magnetic Resonance ◽  
Resonance Imaging ◽  
Imaging Studies ◽  
Term Trial ◽  
Stimulation Of

Abstract OBJECTIVE In the treatment of tremor and rigidity in patients with Parkinson's disease (PD), the prelemniscal radiation (RAPRL), a subthalamic bundle of fibers, is an exquisite target that can be visualized easily on ventriculograms. We sought to evaluate the effect of electrical stimulation of the RAPRL on symptoms and signs of PD in a long-term trial and to determine the localization of the stimulated area by means of stereotactic magnetic resonance imaging studies. METHODS Ten patients with PD predominantly on one side had tetrapolar electrodes stereotactically oriented through a frontal parasagittal approach to the RAPRL contralateral to the most prominent symptoms. Preoperative and postoperative evaluations at 3, 6, 9, and 12 months after surgery were performed using conventional PD scales and quantitative evaluations of tremor amplitude and reaction time. Stereotactic high-resolution magnetic resonance imaging studies with the electrodes in place were used for anatomic localization. RESULTS In all patients, temporary suppression of tremor occurred when the electrodes reached the target. The most effective stimulation was obtained when the pair of contacts was placed in the RAPRL. Long-term stimulation at 130 Hz, 0.09 to 0.450 milliseconds, and 1.5 to 3.0 V produced significant improvement in tremor and rigidity and mild improvement in bradykinesia. CONCLUSION The RAPRL is an effective target for the alleviation of tremor and rigidity in patients with PD by either lesioning or neuromodulation; however, neuromodulation has the advantage of not inducing an increase in bradykinesia. The stimulated area seems to be independent of the subthalamic nucleus.

The long-term results of stereotaxic surgery and L-dopa therapy in patients with Parkinson's disease

1980 ◽  
Vol 53 (3) ◽  
pp. 332-337 ◽  
Author(s):  
Patrick J. Kelly ◽  
F. John Gillingham
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Palliative Therapy ◽  
The Other ◽  
Long Term Results ◽  
Content Type ◽  
Stereotaxic Surgery ◽  
Effective Form

✓ Sixty patients with Parkinson's disease underwent stereotaxic surgery in Edinburgh between 1965 and 1967, and were examined every 2 years for a total follow-up period of 10 years. Although stereotaxic surgery had been extremely effective in treating tremor and rigidity, the other manifestations of Parkinson's disease were noted to progressively affect more patients at each follow-up examination. L-dopa therapy was instituted in 36 patients after 1968. The effect of L-dopa on bradykinesia was remarkable, but the long-term benefit on the other manifestations of Parkinson's disease was negligible. Furthermore, in most cases L-dopa became progressively ineffective for bradykinesia after 3 to 5 years. L-dopa-induced tremor and involuntary movements were less frequently noted in limbs contralateral to the side of a previous stereotaxic procedure. It was concluded that in patients presenting with tremor and rigidity as the major problem in their parkinsonian syndrome, the most effective form of palliative therapy is stereotaxic surgery, and that L-dopa should be reserved for the management of bradykinesia.

Long-term results with cisapride in Parkinson's disease

1997 ◽  
Vol 12 (3) ◽  
pp. 423-425 ◽  
Author(s):  
Wolfgang H. Jost ◽  
Klaus Schimrigk
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results
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