Long-term results of a multicenter study on subthalamic and pallidal stimulation in Parkinson's disease

2010 ◽  
Vol 25 (5) ◽  
pp. 578-586 ◽  
Author(s):  
Elena Moro ◽  
Andres M. Lozano ◽  
Pierre Pollak ◽  
Yves Agid ◽  
Stig Rehncrona ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multicenter Study ◽  
Long Term Results ◽  
Pallidal Stimulation

Long-term results of bilateral pallidal stimulation in Parkinson's disease

2004 ◽  
Vol 55 (6) ◽  
pp. 871-875 ◽  
Author(s):  
Jens Volkmann ◽  
Niels Allert ◽  
J�rgen Voges ◽  
Volker Sturm ◽  
Alfons Schnitzler ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results ◽  
Pallidal Stimulation

Stereotaxic cryosurgery in patients with Parkinson's disease. Long-term results

1997 ◽  
Vol 99 ◽  
pp. S160
Author(s):  
V. Tjumikov ◽  
A. Kadykov ◽  
V. Peresedov ◽  
A. Shirshov ◽  
E. Sungurov ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results

Unilateral Stimulation of Prelemniscal Radiations for the Treatment of Acral Symptoms of Parkinson's Disease: Long-Term Results

2016 ◽  
Vol 19 (4) ◽  
pp. 357-364 ◽  
Author(s):  
Francisco Velasco ◽  
José D. Carrillo-Ruiz ◽  
Víctor Salcido ◽  
Guillermo Castro ◽  
Julián Soto ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results ◽  
Unilateral Stimulation ◽  
Stimulation Of

The long-term results of stereotaxic surgery and L-dopa therapy in patients with Parkinson's disease

1980 ◽  
Vol 53 (3) ◽  
pp. 332-337 ◽  
Author(s):  
Patrick J. Kelly ◽  
F. John Gillingham
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Palliative Therapy ◽  
The Other ◽  
Long Term Results ◽  
Content Type ◽  
Stereotaxic Surgery ◽  
Effective Form

✓ Sixty patients with Parkinson's disease underwent stereotaxic surgery in Edinburgh between 1965 and 1967, and were examined every 2 years for a total follow-up period of 10 years. Although stereotaxic surgery had been extremely effective in treating tremor and rigidity, the other manifestations of Parkinson's disease were noted to progressively affect more patients at each follow-up examination. L-dopa therapy was instituted in 36 patients after 1968. The effect of L-dopa on bradykinesia was remarkable, but the long-term benefit on the other manifestations of Parkinson's disease was negligible. Furthermore, in most cases L-dopa became progressively ineffective for bradykinesia after 3 to 5 years. L-dopa-induced tremor and involuntary movements were less frequently noted in limbs contralateral to the side of a previous stereotaxic procedure. It was concluded that in patients presenting with tremor and rigidity as the major problem in their parkinsonian syndrome, the most effective form of palliative therapy is stereotaxic surgery, and that L-dopa should be reserved for the management of bradykinesia.

Long-term results with cisapride in Parkinson's disease

1997 ◽  
Vol 12 (3) ◽  
pp. 423-425 ◽  
Author(s):  
Wolfgang H. Jost ◽  
Klaus Schimrigk
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Long Term Results

Gamma knife thalamotomy for treatment of tremor: long-term results

2000 ◽  
Vol 93 (supplement_3) ◽  
pp. 128-135 ◽  
Author(s):  
Ronald F. Young ◽  
Skip Jacques ◽  
Rufus Mark ◽  
Oleg Kopyov ◽  
Brian Copcutt ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Essential Tremor ◽  
Gamma Knife ◽  
Rating Scale ◽  
Long Term Results ◽  
Content Type ◽  
Fine Print

Object. The purpose of this study was to investigate the long-term effects of gamma knife thalamotomy for treatment of disabling tremor. Methods. One hundred fifty-eight patients underwent magnetic resonance imaging—guided radiosurgical nucleus ventralis intermedius (VIM) thalamotomy for the treatment of parkinsonian tremor (102 patients), essential tremor (52 patients), or tremor due to stroke, encephalitis, or cerebral trauma (four patients). Preoperative and postoperative blinded assessments were performed by a team of independent examiners skilled in the evolution of movement disorders. A single isocenter exposure with the 4-mm collimator helmet of the Leksell gamma knife unit was used to make the lesions. In patients with Parkinson's disease 88.3% became fully or nearly tremor free, with a mean follow up of 52.5 months. Statistically significant improvements were seen in Unified Parkinson's Disease Rating Scale tremor scores and rigidity scores, and these improvements were maintained in 74 patients followed 4 years or longer. In patients with essential tremor, 92.1% were fully or nearly tremor free postoperatively, but only 88.2% remained tremor free by 4 years or more post-GKS. Statistically significant improvements were seen in the Clinical Rating Scale for tremor in essential tremor patients and these improvements were well maintained in the 17 patients, followed 4 years or longer. Only 50% of patients with tremor of other origins improved significantly. One patient sustained a transient complication and two patients sustained mild permanent side effects from the treatments. Conclusions. Gamma knife VIM thalamotomy provides relief from tremor equivalent to that provided by radiofrequency thalamotomy or deep brain stimulation, but it is safer than either of these alternatives. Long-term follow up indicates that relief of tremor is well maintained. No long-term radiation-induced complications have been observed.

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