scholarly journals Tissue Response to Deep Brain Stimulation and Microlesion: A Comparative Study

2016 ◽  
Vol 19 (5) ◽  
pp. 451-458 ◽  
Author(s):  
Vinata Vedam‐Mai ◽  
Massoud Baradaran‐Shoraka ◽  
Brent A. Reynolds ◽  
Michael S. Okun
Keyword(s):  
Deep Brain Stimulation ◽  
Comparative Study ◽  
Brain Stimulation ◽  
Tissue Response ◽  
Deep Brain

Postmortem analysis following 71 months of deep brain stimulation of the subthalamic nucleus for Parkinson disease

2008 ◽  
Vol 109 (2) ◽  
pp. 325-329 ◽  
Author(s):  
David A. Sun ◽  
Hong Yu ◽  
John Spooner ◽  
Armanda D. Tatsas ◽  
Thomas Davis ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Parkinson Disease ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Zona Incerta ◽  
Foreign Body Giant Cell ◽  
Stn Dbs ◽  
Deep Brain

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a clinically effective neurosurgical treatment for Parkinson disease. Tissue reaction to chronic DBS therapy and the definitive location of active stimulation contacts are best studied on a postmortem basis in patients who have undergone DBS. The authors report the postmortem analysis of STN DBS following 5 years and 11 months of effective chronic stimulation including the histologically verified location of the active contacts associated with bilateral implants. They also describe tissue response to intraoperative test passes with recording microelectrodes and stimulating semimacroelectrodes. The results indicated that 1) the neural tissue surrounding active and nonactive contacts responds similarly, with a thin glial capsule and foreign-body giant cell reaction surrounding the leads as well as piloid gliosis, hemosiderin-laden macrophages, scattered lymphocytes, and Rosenthal fibers; 2) there was evidence of separate tracts in the adjacent tissue for intraoperative microelectrode and semimacroelectrode passes together with reactive gliosis, microcystic degeneration, and scattered hemosiderin deposition; and 3) the active contacts used for ~ 6 years of effective bilateral DBS therapy lie in the zona incerta, just dorsal to the rostral STN. To the authors' knowledge, the period of STN DBS therapy herein described for Parkinson disease and subjected to postmortem analysis is the longest to date.

Comparative Study of Robot-Assisted versus Conventional Frame-Based Deep Brain Stimulation Stereotactic Neurosurgery

2018 ◽  
Vol 96 (5) ◽  
pp. 327-334 ◽  
Author(s):  
Clemens Neudorfer ◽  
Stefan Hunsche ◽  
Martin Hellmich ◽  
Faycal El Majdoub ◽  
Mohammad Maarouf
Keyword(s):  
Deep Brain Stimulation ◽  
Comparative Study ◽  
Brain Stimulation ◽  
Stereotactic Neurosurgery ◽  
Robot Assisted ◽  
Deep Brain

Fibrous Scarring and Deep Brain Stimulation Lead Implantation

2020 ◽  
pp. 137-140
Author(s):  
Vinata Vedam-Mai ◽  
Anthony T. Yachnis ◽  
Michael Ullman ◽  
Saman P. Javedan ◽  
Michael S. Okun
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Disease Status ◽  
Tissue Response ◽  
Fibrous Sheath ◽  
University Of Florida ◽  
Surgical Modality ◽  
The Right ◽  
The University ◽  
Deep Brain

Deep brain stimulation (DBS) has emerged in recent years as a powerful surgical modality for the treatment of several movement disorders as well as neuropsychiatric syndromes. Despite its clinical efficacy, the mode of action of DBS and the cellular responses to this therapy remain unclear. This chapter presents an unusual case from the DBS Brain Tissue Network at the University of Florida of prominent tissue response to DBS. The patient was a 74-year-old man with idiopathic Parkinson disease, status post bilateral STN DBS leads. Neuropathologic examination of the tissue surrounding the distal lead tip of the right DBS using immunohistochemistry revealed a dense, collagen-filled fibrous sheath. There was no intraoperative bleeding during the procedure, and this finding was confirmed by postoperative imaging. Further, there was no perioperative decline in this patient’s condition. It is likely that the fibrous capsule resulted in less than optimal clinical benefit, which was previously reported in this patient. This severe type of exaggerated tissue response to DBS leads has not been observed in other cases in our Brain Bank network and has not been reported previously in the literature, to our knowledge.

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