Clinical course of dengue fever and its impact on renal function in renal transplant recipients and patients with chronic kidney disease

Nephrology ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 564-568 ◽  
Author(s):  
E.T Arun Thomas ◽  
Jacob George ◽  
Devi Sruthi ◽  
N. S. Vineetha ◽  
Noble Gracious
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Dengue Fever ◽  
Clinical Course ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Influence of acute moderate- to high-intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients

2020 ◽  
Vol 318 (1) ◽  
pp. F76-F85
Author(s):  
Patrick J. Highton ◽  
Alice E. M. White ◽  
Daniel G. D. Nixon ◽  
Thomas J. Wilkinson ◽  
Jill Neale ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Tissue Factor ◽  
Control Group ◽  
Monocyte Subset ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
The Impact

Renal transplant recipients (RTRs) and patients with nondialysis chronic kidney disease display elevated circulating microparticle (MP) counts, while RTRs display immunosuppression-induced infection susceptibility. The impact of aerobic exercise on circulating immune cells and MPs is unknown in RTRs. Fifteen RTRs [age: 52.8 ± 14.5 yr, estimated glomerular filtration rate (eGFR): 51.7 ± 19.8 mL·min−1·1.73 m−2 (mean ± SD)] and 16 patients with nondialysis chronic kidney disease (age: 54.8 ± 16.3 yr, eGFR: 61.9 ± 21.0 mL·min−1·1.73 m−2, acting as a uremic control group), and 16 healthy control participants (age: 52.2 ± 16.2 yr, eGFR: 85.6 ± 6.1 mL·min−1·1.73 m−2) completed 20 min of walking at 60–70% peak O2 consumption. Venous blood samples were taken preexercise, postexercise, and 1 h postexercise. Leukocytes and MPs were assessed using flow cytometry. Exercise increased classical ( P = 0.001) and nonclassical ( P = 0.002) monocyte subset proportions but decreased the intermediate subset ( P < 0.001) in all groups. Exercise also decreased the percentage of platelet-derived MPs that expressed tissue factor in all groups ( P = 0.01), although no other exercise-dependent effects were observed. The exercise-induced reduction in intermediate monocyte percentage suggests an anti-inflammatory effect, although this requires further investigation. The reduction in the percentage of tissue factor-positive platelet-derived MPs suggests reduced prothrombotic potential, although further functional assays are required. Exercise did not cause aberrant immune cell activation, suggesting its safety from an immunological standpoint (ISRCTN38935454).

Prevalence and staging of chronic kidney disease in renal transplant recipients

2009 ◽  
Vol 23 (5) ◽  
pp. 628-636 ◽  
Author(s):  
Cláudia Maria Costa de Oliveira ◽  
Márcia Uchoa Mota ◽  
Rosa Salani Mota ◽  
Joana Oliveira Nóbrega ◽  
Débora Silva Melo ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

Chronic Kidney Disease in Renal Transplant Recipients

2005 ◽  
Vol 37 (9) ◽  
pp. 3718-3720 ◽  
Author(s):  
R. Marcén ◽  
J. Pascual ◽  
M. Tenorio ◽  
E.J. Ocaña ◽  
J.L. Teruel ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Renal Transplant Recipients ◽  
Transplant Recipients

scholarly journals Two Japanese patients with stage G3b chronic kidney disease and impaired glucose metabolism after renal transplantation successfully treated with empagliflozin

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Ryoichi Miyazaki ◽  
Kyoko Miyagi ◽  
Misaki Yoshida
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplantation ◽  
Renal Transplant ◽  
Glucose Metabolism ◽  
Kidney Disease ◽  
Transplant Recipient ◽  
Sglt2 Inhibitors ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Abnormal Glucose Metabolism

Abstract Background Renal transplant recipients with chronic kidney disease (CKD) often develop abnormal glucose metabolism. Although recent studies have reported the protective effects of sodium-glucose transport protein 2 (SGLT2) inhibitors on the heart and kidneys, few have assessed their effect in renal transplant patients. Moreover, to our knowledge, there have been no studies on the effects of SGLT2 inhibitors in renal transplant recipients in Japan. Case presentation Case 1 was a 67-year-old male renal transplant recipient with post-transplant diabetes mellitus. He was administered empagliflozin 10 mg once a day for 9 months. Over time, his HbA1c levels decreased from 6.8 to 6.0%. Case 2 was a 56-year-old male renal transplant recipient with fatty liver disease. He was administered empagliflozin 10 mg once a day for 9 months. His ALT, γ-GTP, and LDL-cholesterol levels all decreased. In both patients, body weight and the urine albumin to creatinine ratio (UACR) decreased after empagliflozin administration, but there were no changes in the estimated glomerular filtration rate. No adverse events occurred in either case. Conclusions Administration of empagliflozin had favorable outcomes in two patients with stage G3b CKD and abnormal glucose metabolism after renal transplantation. Further studies will be required to clarify the efficacy and safety of SGLT2 inhibitors in a larger population of patients with similar medical conditions.

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