Concordance of Estimated Glomerular Filtration Rates Using Cockcroft-Gault, Modification of Diet in Renal Disease, and Chronic Kidney Disease Epidemiology in Renal Transplant Recipients

2012 ◽  
Vol 44 (9) ◽  
pp. 2561-2563 ◽  
Author(s):  
P. Ruiz-Esteban ◽  
V. López ◽  
P. García-Frías ◽  
M. Cabello ◽  
M. González-Molina ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Renal Disease ◽  
Glomerular Filtration ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Disease Epidemiology ◽  
Estimated Glomerular Filtration Rates

scholarly journals Influence of acute moderate- to high-intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients

2020 ◽  
Vol 318 (1) ◽  
pp. F76-F85
Author(s):  
Patrick J. Highton ◽  
Alice E. M. White ◽  
Daniel G. D. Nixon ◽  
Thomas J. Wilkinson ◽  
Jill Neale ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Transplant ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Tissue Factor ◽  
Control Group ◽  
Monocyte Subset ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
The Impact

Renal transplant recipients (RTRs) and patients with nondialysis chronic kidney disease display elevated circulating microparticle (MP) counts, while RTRs display immunosuppression-induced infection susceptibility. The impact of aerobic exercise on circulating immune cells and MPs is unknown in RTRs. Fifteen RTRs [age: 52.8 ± 14.5 yr, estimated glomerular filtration rate (eGFR): 51.7 ± 19.8 mL·min−1·1.73 m−2 (mean ± SD)] and 16 patients with nondialysis chronic kidney disease (age: 54.8 ± 16.3 yr, eGFR: 61.9 ± 21.0 mL·min−1·1.73 m−2, acting as a uremic control group), and 16 healthy control participants (age: 52.2 ± 16.2 yr, eGFR: 85.6 ± 6.1 mL·min−1·1.73 m−2) completed 20 min of walking at 60–70% peak O2 consumption. Venous blood samples were taken preexercise, postexercise, and 1 h postexercise. Leukocytes and MPs were assessed using flow cytometry. Exercise increased classical ( P = 0.001) and nonclassical ( P = 0.002) monocyte subset proportions but decreased the intermediate subset ( P < 0.001) in all groups. Exercise also decreased the percentage of platelet-derived MPs that expressed tissue factor in all groups ( P = 0.01), although no other exercise-dependent effects were observed. The exercise-induced reduction in intermediate monocyte percentage suggests an anti-inflammatory effect, although this requires further investigation. The reduction in the percentage of tissue factor-positive platelet-derived MPs suggests reduced prothrombotic potential, although further functional assays are required. Exercise did not cause aberrant immune cell activation, suggesting its safety from an immunological standpoint (ISRCTN38935454).

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