Urinary interleukin-6 and interleukin-8 in children with urinary tract infection

2000 ◽  
Vol 15 (3-4) ◽  
pp. 236-240 ◽  
Author(s):  
B. A. Jantausch ◽  
Regina O'Donnell ◽  
Bernhard L. Wiedermann
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Interleukin 6 ◽  
Interleukin 8

scholarly journals Uropathogenic Escherichia coli-Induced Inflammation Alters Mouse Urinary Bladder Contraction via an Interleukin-6-Activated Inducible Nitric Oxide Synthase-Related Pathway

2009 ◽  
Vol 77 (8) ◽  
pp. 3312-3319 ◽  
Author(s):  
Te I. Weng ◽  
Hsiao Yi Wu ◽  
Pei Ying Lin ◽  
Shing Hwa Liu
Keyword(s):  
Nitric Oxide ◽  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Urinary Bladder ◽  
Tract Infection ◽  
Interleukin 6 ◽  
Electrical Field Stimulation ◽  
E Coli

ABSTRACT Escherichia coli is the most common cause of urinary tract infection. Elevated blood and urine interleukin-6 (IL-6) levels have been shown in inflammatory urinary tract diseases. The role of IL-6 in mediating the urodynamic dysfunction in response to E. coli-induced urinary tract infection has not yet been fully elucidated. In this study, we investigated the role of IL-6 in the nitric oxide (NO)-triggered alteration of contractile responses in the urinary bladder under an E. coli-induced inflammatory condition. The electrical field stimulation (EFS)-evoked contractions of the isolated detrusor strips, and immunoblotting for detecting protein expression in the bladders was measured short term (1 h) or long term (6 or 24 h) after intraperitoneal injection of E. coli endotoxin (lipopolysaccharide [LPS]) or intravesical instillation of human pyelonephritogenic E. coli-J96 (O4:K6) strain or LPS into mice. IL-6 and NO productions were increased in the urinary bladders of mice 1 to 24 h after LPS or E. coli-J96 treatment. Inducible NO synthase (iNOS) expression and protein kinase C (PKC) activation and EFS-evoked detrusor contractions were increased in the bladders at 6 h after LPS or E. coli-J96 treatment, which could be reversed by anti-IL-6 antibody and iNOS inhibitor aminoguanidine. At 1 h after LPS administration, bladder NO generation, endothelial NOS expression, and EFS-evoked detrusor contractions were effectively increased, whereas anti-IL-6 antibody could not reverse these LPS-induced responses. These results indicate that IL-6 may play an important role in the iNOS/NO-triggered PKC-activated contractile response in urinary bladder during E. coli or LPS-induced inflammation.

Urine Interleukin-8 Is a Marker for Urinary Tract Infection in Postoperative Patients

Infection ◽  
2001 ◽  
Vol 29 (5) ◽  
pp. 274-277 ◽  
Author(s):  
D.P. Olszyna ◽  
H. Vermeulen ◽  
A.H. Baan ◽  
P. Speelman ◽  
S.J.H. van Deventer ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Interleukin 8

Association between interleukin 8‐receptor gene (CXCR1 and CXCR2) polymorphisms and urinary tract infection: Evidence from 4097 subjects

Nephrology ◽  
2019 ◽  
Vol 24 (4) ◽  
pp. 464-471 ◽  
Author(s):  
Shi‐Sheng Han ◽  
Yan Lu ◽  
Min Chen ◽  
Yan‐Qiu Xu ◽  
Yi Wang
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Receptor Gene ◽  
Interleukin 8

scholarly journals Evaluation of Procalcitonin and Interleukin-6 as a Marker of Bacterial Urinary Tract Infection

2022 ◽  
Vol 67 (4) ◽  
pp. 203-213
Author(s):  
Suhaila N. Darogha ◽  
Sarhang H. Azeez ◽  
Zhian G. Abdullah
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Interleukin 6 ◽  
Diagnostic Methods ◽  
High Morbidity ◽  
Control Groups ◽  
High Morbidity Rate ◽  
Significant Difference ◽  
And Control

Urinary tract infection (UTI) is a major clinical problem in a wide age range that is associated with a high morbidity rate. Due to issues such as low specificity and the inability to differentiate between different types of infection in current diagnostic methods, there is a need to introduce novel UTI markers. The present study was conducted to evaluate the utility of Procalcitonin (PCT) and interleukin-6 (IL-6) as a marker of bacterial urinary tract infection. For this purpose, a cross-sectional study was conducted between November 2020 and February 2021 among 125 patients and 60 healthy volunteers (control) in Erbil Teaching Hospital. The concentration of PCT and IL-6 was quantified using the ELISA cloud immunoassay test. Between-group comparisons were assessed for the variables with analysis of variance. The results revealed that there was a significant difference between PCT levels in UTI patients (104.6±6.07) and control groups (54±2.24) (p <0.0001). The differences in IL-6 concentration in UTI patients (55.74±4.2) and control groups (24.56±2.4) were also significant (p <0.0001), implying that the level of both PCT and IL-6 increased due to bacterial infection in the urinary tract. As a whole, the findings of this study provide

scholarly journals Diagnostic value of urinary interleukin-6 in urinary tract infection in children.

GEGET ◽  
2019 ◽  
Vol 14 (2) ◽  
pp. 12-19
Author(s):  
Huda Marzouk ◽  
Emad Ghobrial ◽  
Mervat Khorshied ◽  
Safaa Samuel
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Interleukin 6 ◽  
Diagnostic Value
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