Proliferative glomerulonephritis with monoclonal immunoglobulin A light-chain deposits in the renal allograft

Nephrology ◽  
2014 ◽  
Vol 19 ◽  
pp. 49-51 ◽  
Author(s):  
Kiyoshi Setoguchi ◽  
Yoichiro Kawashima ◽  
Tadahiko Tokumoto ◽  
Hiroshi Toma ◽  
Shogo Mizoguchi ◽  
...  
Keyword(s):  
Light Chain ◽  
Renal Allograft ◽  
Immunoglobulin A ◽  
Proliferative Glomerulonephritis ◽  
Monoclonal Immunoglobulin

scholarly journals Nephrotic Syndrome Secondary to Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits of Lambda Light Chain

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Seongseok Yun ◽  
Beth L. Braunhut ◽  
Courtney N. Walker ◽  
Waheed Bhati ◽  
Amy N. Sussman ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Light Chain ◽  
Hematologic Malignancies ◽  
Proliferative Glomerulonephritis ◽  
Lambda Light Chain ◽  
Monoclonal Immunoglobulin ◽  
Subendothelial Space ◽  
History Of ◽  
Immunoglobulin Deposits ◽  
Refractory Nephrotic Syndrome

We describe a rare case of a 46-year-old woman with history of refractory nephrotic syndrome and hypertension who presented with worsening proteinuria and kidney function. Work-up for both autoimmune and infectious diseases and hematologic malignancies including multiple myeloma were negative. Kidney biopsy demonstrated glomerular sclerotic change with lambda light chain deposits in the subendothelial space, which is consistent with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID). The patient was treated with bortezomib and dexamethasone without clinical improvement and eventually became hemodialysis dependent.

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