A case of endocapillary proliferative glomerulonephritis with macrophages phagocytosing monoclonal immunoglobulin lambda light chain

2014 ◽  
Vol 65 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Hirofumi Watanabe ◽  
Yutaka Osawa ◽  
Shin Goto ◽  
Masato Habuka ◽  
Naofumi Imai ◽  
...  
Keyword(s):  
Light Chain ◽  
Proliferative Glomerulonephritis ◽  
Lambda Light Chain ◽  
Monoclonal Immunoglobulin ◽  
Endocapillary Proliferative Glomerulonephritis ◽  
Immunoglobulin Lambda

scholarly journals Nephrotic Syndrome Secondary to Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits of Lambda Light Chain

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
Seongseok Yun ◽  
Beth L. Braunhut ◽  
Courtney N. Walker ◽  
Waheed Bhati ◽  
Amy N. Sussman ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Light Chain ◽  
Hematologic Malignancies ◽  
Proliferative Glomerulonephritis ◽  
Lambda Light Chain ◽  
Monoclonal Immunoglobulin ◽  
Subendothelial Space ◽  
History Of ◽  
Immunoglobulin Deposits ◽  
Refractory Nephrotic Syndrome

We describe a rare case of a 46-year-old woman with history of refractory nephrotic syndrome and hypertension who presented with worsening proteinuria and kidney function. Work-up for both autoimmune and infectious diseases and hematologic malignancies including multiple myeloma were negative. Kidney biopsy demonstrated glomerular sclerotic change with lambda light chain deposits in the subendothelial space, which is consistent with proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID). The patient was treated with bortezomib and dexamethasone without clinical improvement and eventually became hemodialysis dependent.

Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus

1999 ◽  
Vol 104 (5) ◽  
pp. 361-369 ◽  
Author(s):  
Marie-Paule Lefranc ◽  
Nathalie Pallarès ◽  
Jean-Pol Frippiat
Keyword(s):  
Light Chain ◽  
Human Immunoglobulin ◽  
Lambda Light Chain ◽  
Chain Locus ◽  
Light Chain Locus ◽  
Immunoglobulin Lambda

The origin of deletion 22q11 in chronic lymphocytic leukemia is related to the rearrangement of immunoglobulin lambda light chain locus

2013 ◽  
Vol 37 (7) ◽  
pp. 802-808 ◽  
Author(s):  
Marek Mraz ◽  
Katerina Stano Kozubik ◽  
Karla Plevova ◽  
Katerina Musilova ◽  
Boris Tichy ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Light Chain ◽  
Lymphocytic Leukemia ◽  
Lambda Light Chain ◽  
Deletion 22Q11 ◽  
Chain Locus ◽  
Light Chain Locus ◽  
Immunoglobulin Lambda

Myeloma Associated with Immunoglobulin Lambda-light Chain Derived Amyloid in a Dog

1990 ◽  
Vol 27 (5) ◽  
pp. 374-376 ◽  
Author(s):  
O. Geisel ◽  
M. Stiglmair-Herb ◽  
R. P. Linke
Keyword(s):  
Light Chain ◽  
Lambda Light Chain ◽  
Immunoglobulin Lambda
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