Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression

2019 ◽  
Vol 46 (2) ◽  
pp. 125-141 ◽  
Author(s):  
H. Kim ◽  
K.‐J. Park ◽  
B.‐K. Ryu ◽  
D.‐H. Park ◽  
D.‐S. Kong ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Human Meningioma ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Oncogenic Driver

scholarly journals Forkhead Box m1 transcription factor is required for perinatal lung function

2008 ◽  
Vol 105 (49) ◽  
pp. 19330-19335 ◽  
Author(s):  
T. V. Kalin ◽  
I-C. Wang ◽  
L. Meliton ◽  
Y. Zhang ◽  
S. E. Wert ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Function ◽  
Forkhead Box ◽  
Forkhead Box M1

scholarly journals Anticancer activity of eugenol is not related to regulation of the oncogenic transcription factor Forkhead Box M1

2016 ◽  
Vol 38 (2) ◽  
pp. 159
Author(s):  
Luiz Alexandre Marques Wiirzler ◽  
Rafael Pazinatto Aguiar ◽  
Ciomar Aparecida Bersani-Amado ◽  
Carlos Alberto Velázquez-Martínez ◽  
Roberto Kenji Nakamura Cuman
Keyword(s):  
Transcription Factor ◽  
Anticancer Activity ◽  
Factor I ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Oncogenic Transcription Factor

scholarly journals Forkhead box M1 transcription factor: A novel target for cancer therapy

2010 ◽  
Vol 36 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Zhiwei Wang ◽  
Aamir Ahmad ◽  
Yiwei Li ◽  
Sanjeev Banerjee ◽  
Dejuan Kong ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cancer Therapy ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Novel Target

scholarly journals The Forkhead Box M1 Transcription Factor Is Essential for Embryonic Development of Pulmonary Vasculature

2005 ◽  
Vol 280 (23) ◽  
pp. 22278-22286 ◽  
Author(s):  
Il-Man Kim ◽  
Sneha Ramakrishna ◽  
Galina A. Gusarova ◽  
Helena M. Yoder ◽  
Robert H. Costa ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Pulmonary Vasculature ◽  
Matrix Remodeling ◽  
Knock Out ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Expression Of Genes

Transgenic and gene knock-out studies demonstrated that the mouse Forkhead Box m1 (Foxm1 or Foxm1b) transcription factor (previously called HFH-11B, Trident, Win, or MPP2) is essential for hepatocyte entry into mitosis during liver development, regeneration, and liver cancer. Targeted deletion of Foxm1 gene in mice produces an embryonic lethal phenotype due to severe abnormalities in the development of liver and heart. In this study, we show for the first time that Foxm1–/– lungs exhibit severe hypertrophy of arteriolar smooth muscle cells and defects in the formation of peripheral pulmonary capillaries as evidenced by significant reduction in platelet endothelial cell adhesion molecule 1 staining of the distal lung. Consistent with these findings, significant reduction in proliferation of the embryonic Foxm1–/– lung mesenchyme was found, yet proliferation levels were normal in the Foxm1-deficient epithelial cells. Severe abnormalities of the lung vasculature in Foxm1–/– embryos were associated with diminished expression of the transforming growth factor β receptor II, a disintegrin and metalloprotease domain 17 (ADAM-17), vascular endothelial growth factor receptors, Polo-like kinase 1, Aurora B kinase, laminin α4 (Lama4), and the Forkhead Box f1 transcription factor. Cotransfection studies demonstrated that Foxm1 stimulates transcription of the Lama4 promoter, and this stimulation requires the Foxm1 binding sites located between –1174 and –1145 bp of the mouse Lama4 promoter. In summary, development of mouse lungs depends on the Foxm1 transcription factor, which regulates expression of genes essential for mesenchyme proliferation, extracellular matrix remodeling, and vasculogenesis.

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