scholarly journals Forkhead box M1 transcription factor: A novel target for cancer therapy

2010 ◽  
Vol 36 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Zhiwei Wang ◽  
Aamir Ahmad ◽  
Yiwei Li ◽  
Sanjeev Banerjee ◽  
Dejuan Kong ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cancer Therapy ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Novel Target

Forkhead box M1 (FOXM1) transcription factor is a key oncogenic driver of aggressive human meningioma progression

2019 ◽  
Vol 46 (2) ◽  
pp. 125-141 ◽  
Author(s):  
H. Kim ◽  
K.‐J. Park ◽  
B.‐K. Ryu ◽  
D.‐H. Park ◽  
D.‐S. Kong ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Human Meningioma ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Oncogenic Driver

scholarly journals Forkhead Box m1 transcription factor is required for perinatal lung function

2008 ◽  
Vol 105 (49) ◽  
pp. 19330-19335 ◽  
Author(s):  
T. V. Kalin ◽  
I-C. Wang ◽  
L. Meliton ◽  
Y. Zhang ◽  
S. E. Wert ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Lung Function ◽  
Forkhead Box ◽  
Forkhead Box M1

scholarly journals Anticancer activity of eugenol is not related to regulation of the oncogenic transcription factor Forkhead Box M1

2016 ◽  
Vol 38 (2) ◽  
pp. 159
Author(s):  
Luiz Alexandre Marques Wiirzler ◽  
Rafael Pazinatto Aguiar ◽  
Ciomar Aparecida Bersani-Amado ◽  
Carlos Alberto Velázquez-Martínez ◽  
Roberto Kenji Nakamura Cuman
Keyword(s):  
Transcription Factor ◽  
Anticancer Activity ◽  
Factor I ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Oncogenic Transcription Factor

scholarly journals Involvement of miR-214-3p/FOXM1 axis during the progression of psoriasis

2021 ◽  
Author(s):  
Jin Zhao ◽  
Fei Wang ◽  
Qingjun Tian ◽  
Jing Dong ◽  
Liuqing Chen ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Cyclin B1 ◽  
Mrna Degradation ◽  
Hacat Cells ◽  
Forkhead Box ◽  
Forkhead Box M1 ◽  
Non Coding Rnas ◽  
Novel Target

Abstract Psoriasis is a common, chronic, and relapsing skin disease characterized by hyperproliferation of keratinocytes and apoptosis delay. However, the molecular mechanisms underlying the progression of psoriasis remain elusive. MicroRNAs (miRNAs) are single-stranded, small non-coding RNAs that play a crucial role in the development of psoriasis by promoting targeted mRNA degradation or translational inhibition. Here, we report that miR-214-3p, one of the down-regulated miRNAs identified in the skin of psoriatic patients and imiquimod (IMQ)-induced mouse models, can negatively regulate the expression of forkhead box M1 (FOXM1). miR-214-3p inhibition leads to hyperproliferation and increased apoptosis of keratinocytes in vitro. Moreover, we show that miR-214-3p inhibition causes an arrest of the cell cycle at the S stage by elevating the expression of NEK2, KIF20A, CENP-A, CENP-F, Cyclin B1, and by reducing the expression of Cyclin D1 in HaCaT cells. In vivo, administration of miR-214-3p attenuates the psoriasis-like phenotype in IMQ-induced mice. Collectively, our results suggest that miR-214-3p/FOXM1 axis in keratinocytes could be a novel target in the treatment of psoriasis.

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