scholarly journals Phosphatidylinositol‐4,5‐bisphosphate is enriched in granulovacuolar degeneration bodies and neurofibrillary tangles

2014 ◽  
Vol 40 (4) ◽  
pp. 489-501 ◽  
Author(s):  
Tomokazu Nishikawa ◽  
Tetsuya Takahashi ◽  
Masahiro Nakamori ◽  
Yu Yamazaki ◽  
Takashi Kurashige ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Granulovacuolar Degeneration ◽  
Granulovacuolar Degeneration Bodies

The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway

2017 ◽  
Vol 638 ◽  
pp. 55-59 ◽  
Author(s):  
Yukari Murata-Shinozaki ◽  
Tetsuya Takahashi ◽  
Tomoyasu Matsubara ◽  
Hirofumi Maruyama ◽  
Yuishin Izumi ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Granulovacuolar Degeneration ◽  
Rimmed Vacuoles ◽  
Granulovacuolar Degeneration Bodies

scholarly journals Lysosomal Fusion Dysfunction as a Unifying Hypothesis for Alzheimer's Disease Pathology

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Kristen E. Funk ◽  
Jeff Kuret
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Neurofibrillary Tangles ◽  
Recent Literature ◽  
Senile Plaques ◽  
Disease Onset ◽  
Granulovacuolar Degeneration

Alzheimer's disease is characterized pathologically by extracellular senile plaques, intracellular neurofibrillary tangles, and granulovacuolar degeneration. It has been debated whether these hallmark lesions are markers or mediators of disease progression, and numerous paradigms have been proposed to explain the appearance of each lesion individually. However, the unfaltering predictability of these lesions suggests a single pathological nidus central to disease onset and progression. One of the earliest pathologies observed in Alzheimer's disease is endocytic dysfunction. Here we review the recent literature of endocytic dysfunction with particular focus on disrupted lysosomal fusion and propose it as a unifying hypothesis for the three most-studied lesions of Alzheimer's disease.

scholarly journals Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Sally Hunter ◽  
◽  
Thais Minett ◽  
Tuomo Polvikoski ◽  
Elizabeta Mukaetova-Ladinska ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Granulovacuolar Degeneration

scholarly journals Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels

2022 ◽  
Vol 10 (1) ◽  
Author(s):  
Malin Wennström ◽  
Shorena Janelidze ◽  
K. Peter R. Nilsson ◽  
Geidy E. Serrano ◽  
Thomas G. Beach ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Cellular Localization ◽  
Amyloid Plaques ◽  
Area Fraction ◽  
Granulovacuolar Degeneration ◽  
Plasma Biomarker ◽  
Age Related ◽  
Plaque Load ◽  
The Mean ◽  
Granulovacuolar Degeneration Bodies

AbstractRecent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer’s disease (AD), but the specific brain pathological events related to the alteration in p-tau217 plasma levels are still largely unknown. Using immunostaining techniques of postmortem AD brain tissue, we show that p-tau217 is found in neurofibrillary tangles (NFTs) and neuropil threads that are also positive for p-tau181, 202, 202/205, 231, and 369/404. The p-tau217, but not the other five p-tau variants, was also prominently seen in vesicles structure positive for markers of granulovacuolar degeneration bodies and multi-vesicular bodies. Further, individuals with a high likelihood of AD showed significantly higher p-tau217 area fraction in 4 different brain areas (entorhinal cortex, inferior temporal gyrus, and superior frontal gyrus) compared to those with Primary age related tauopathy or other non-AD tauopathies. The p-tau217 area fraction correlated strongly with total amyloid-beta (Aβ) and NFT brain load when the whole group was analyzed. Finally, the mean p-tau217 area fraction correlated significantly with p-tau217 concentrations in antemortem collected plasma specifically in individuals with amyloid plaques and not in those without amyloid plaques. These studies highlight differences in cellular localization of different p-tau variants and suggest that plasma levels of p-tau217 reflect an accumulation of p-tau217 in presence of Aβ plaque load.

TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer’s Disease

2017 ◽  
Vol 58 (4) ◽  
pp. 1027-1033 ◽  
Author(s):  
Sandra L. Siedlak ◽  
Yinfei Jiang ◽  
Mikayla L. Huntley ◽  
Luwen Wang ◽  
Ju Gao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dystrophic Neurites ◽  
Granulovacuolar Degeneration ◽  
Granulovacuolar Degeneration Bodies
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