An open label non‐inferiority randomized control trial comparing nebulized amphotericin B with oral itraconazole in patients with pulmonary aspergilloma

Mycoses ◽  
2021 ◽  
Author(s):  
Animesh Ray ◽  
Jagdeesh Manikanta ◽  
Komal Singh ◽  
Pavan Gabra ◽  
Surabhi Vyas ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Randomized Control Trial ◽  
Open Label ◽  
Oral Itraconazole ◽  
Pulmonary Aspergilloma ◽  
Randomized Control

scholarly journals Effect of pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial

2017 ◽  
Vol 5 (3) ◽  
pp. 155-163 ◽  
Author(s):  
Shahinul Alam ◽  
SKM Nazmul Hasan ◽  
Golam Mustafa ◽  
Mahabubul Alam ◽  
Mohammad Kamal ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Nonalcoholic Steatohepatitis ◽  
Randomized Control Trial ◽  
Lifestyle Modification ◽  
Control Group ◽  
Open Label ◽  
Histological Activity ◽  
Randomized Control ◽  
One Year ◽  
Lobular Inflammation

AbstractBackground and ObjectivesTo observe the effect of Pentoxifylline for 1 year on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis (NASH).Materials and MethodsA single center, open label Randomized Control Trial. Patients were included if they had ultrasonographic evidence of fatty liver and nonalcoholic fatty liver disease activity score (NAS) ≥ 5 on liver histology. A total of 35 patients were selected; 25 of PL (Experimental) group and 10 of L (Control) group. PL group received 400 mg pentoxifylline thrice daily along with lifestyle modification and there was only lifestyle modification for the L group. After one year, NAS and fibrosis was compared in both groups.ResultsIn PL group, NAS improved 2.10 ± 1.07; whereas in L group, NAS was 0.90 ± 0.99 (P = 0.006). As per the protocol analysis, NAS ≥ 2 improved in 15/20 (75%) in PL group and in 3/10 (30%) in L group (P = 0.018). In PL group, the individual component of NAS, steatosis improved from 2.30 ± 0.66 to 0.95 ± 0.76 (P = 0.000), lobular inflammation from 1.65 ± 0.59 to 1.05 ± 0.51 (P = 0.002) and hepatocyte ballooning from 1.50 ± 0.51 to 1.30 ± 0.57 (P = 0.258). In L group, steatosis improved from 2.30 ± 0.68 to 1.40 ± 1.08 (P = 0.01), lobular inflammation and hepatocyte ballooning did not improve. The fibrosis score did not improve in any group. In PL group, NAS improved significantly (P = 0.027; OR=22.76, CI=1.43-362.40) independent of weight reduction.ConclusionPentoxifylline for 1 year improves the hepatic histological activity but not fibrosis of NASH patients.

scholarly journals An open-label, randomized, non-inferiority trial of the efficacy and safety of ciprofloxacin versus streptomycin + ciprofloxacin in the treatment of bubonic plague (IMASOY): study protocol for a randomized control trial

Trials ◽  
2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Rindra Vatosoa Randremanana ◽  
Mihaja Raberahona ◽  
Mamy Jean de Dieu Randria ◽  
Minoarisoa Rajerison ◽  
Voahangy Andrianaivoarimanana ◽  
...  
Keyword(s):  
Study Protocol ◽  
Randomized Control Trial ◽  
Efficacy And Safety ◽  
Bubonic Plague ◽  
Open Label ◽  
Randomized Control

scholarly journals Long term protective level of hepatitis B antibody after revaccination in liver transplanted children: an open-label randomized control trial study

2021 ◽  
Vol 35 (1) ◽  
pp. S141-S141
Author(s):  
Palittiya Sintusek ◽  
Yong Poovorawan ◽  
Supranee Buranapraditkun ◽  
Piyaporn Wanawongsawad ◽  
Ai-lada Intrarakamhang
Keyword(s):  
Hepatitis B ◽  
Randomized Control Trial ◽  
Protective Level ◽  
Open Label ◽  
Randomized Control

scholarly journals Impact of diet and nutraceutical supplementation on inflammation in elderly people. Results from the RISTOMED study, an open-label randomized control trial

2016 ◽  
Vol 35 (4) ◽  
pp. 812-818 ◽  
Author(s):  
R. Ostan ◽  
M.C. Béné ◽  
L. Spazzafumo ◽  
A. Pinto ◽  
L.M. Donini ◽  
...  
Keyword(s):  
Elderly People ◽  
Randomized Control Trial ◽  
Open Label ◽  
Randomized Control

scholarly journals The Use of NeuroAiD (MLC601) in Postischemic Stroke Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Jose C. Navarro ◽  
Mark C. Molina ◽  
Alejandro C. Baroque II ◽  
Johnny K. Lokin
Keyword(s):  
Functional Recovery ◽  
Randomized Control Trial ◽  
Retrospective Cohort ◽  
Data Bank ◽  
Modified Rankin Scale ◽  
Stroke Patients ◽  
Open Label ◽  
Large Randomized Control Trial ◽  
Randomized Control ◽  
Stroke Data Bank

Aim. We aimed to assess the efficacy of MLC601 on functional recovery in patients given MLC601 after an ischemic stroke.Methods. This is a retrospective cohort study comparing poststroke patients given open-label MLC601 (; 9 female) for three months and matching patients who did not receive MLC601 from our Stroke Data Bank. Outcome assessed was modified Rankin Scale (mRS) at three months and analyzed according to: (1) achieving a score of 0-2, (2) achieving a score of 0-1, and (3) mean change in scores from baseline.Results. At three months, 21 patients on MLC601 became independent as compared to 17 patients not on MLC601 (OR 1.79; 95% CI 0.62–5.2; ). There were twice as many patients () on MLC601 who attained mRS scores similar to their prestroke state than in the non-MLC601 group () (OR 3.14; 95% CI 1.1–9.27; ). Mean improvement in mRS from baseline was better in the MLC601 group than in the non-MLC601 group (−1.7 versus −0.9; mean difference −0.73; 95% CI −1.09 to −0.38; ).Conclusion. MLC601 improves functional recovery at 3 months postischemic stroke. An ongoing large randomized control trial of MLC601 will help validate these results.

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