In vitro antifungal activity of amphotericin B and 11 comparators against Aspergillus terreus species complex

Mycoses ◽  
2017 ◽  
Vol 61 (2) ◽  
pp. 134-142 ◽  
Author(s):  
Afsane Vaezi ◽  
Hamed Fakhim ◽  
Amir Arastehfar ◽  
Tahereh Shokohi ◽  
Mohammad T. Hedayati ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Species Complex ◽  
Aspergillus Terreus ◽  
In Vitro Antifungal Activity

scholarly journals Antifungal Activity of Flocculosin, a Novel Glycolipid Isolated from Pseudozyma flocculosa

2005 ◽  
Vol 49 (4) ◽  
pp. 1597-1599 ◽  
Author(s):  
Benjamin Mimee ◽  
Caroline Labbé ◽  
René Pelletier ◽  
Richard R. Bélanger
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Cell Lines ◽  
Human Cell ◽  
Synergistic Activity ◽  
Human Cell Lines ◽  
Antifungal Properties ◽  
Pseudozyma Flocculosa ◽  
In Vitro Antifungal Activity

ABSTRACT Flocculosin, a glycolipid isolated from the yeast-like fungus Pseudozyma flocculosa, was investigated for in vitro antifungal activity. The compound displayed antifungal properties against several pathogenic yeasts. Synergistic activity was observed between flocculosin and amphotericin B, and no significant cytotoxicity was demonstrated when tested against human cell lines.

Amphotericin B in Lipid Emulsion: Stability, Compatibility, and In Vitro Antifungal Activity

1998 ◽  
Vol 42 (4) ◽  
pp. 762-766 ◽  
Author(s):  
Scott Walker ◽  
Sandra A. N. Tailor ◽  
Mark Lee ◽  
Lisa Louie ◽  
Marie Louie ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Clinical Laboratory ◽  
National Committee ◽  
Compatibility Study ◽  
The Stability ◽  
Few Data ◽  
Reference Strains ◽  
In Vitro Antifungal Activity

ABSTRACT Newer formulations of amphotericin B (AmB) complexed with liposomes or lipid suspensions have been developed. Preliminary studies have suggested that AmB in Intralipid (IL) may be as effective as, but less toxic than, conventional formulations of AmB, but few data are available regarding its stability, compatibility, or in vitro antifungal activity. A compatibility study was done to evaluate the effects of AmB concentrations in IL containing either 10 or 20% soybean oil. The effects of temperature, shaking, and AmB and IL concentrations on the stability of AmB-IL suspensions were analyzed by visual inspection and liquid chromatography. The in vitro antifungal activity of AmB-IL, compared to that of AmB alone against reference strains of Candida species was determined by using a broth macrodilution method in accordance with National Committee for Clinical Laboratory Standards guidelines (M27-T). Samples of AmB-IL which were lightly shaken retained more than 90% of the AmB concentration over 21 days when stored at either 4 or 23°C. Varying the AmB concentration did not appear to affect the stability of AmB-IL. However, a precipitate was formed when mixtures with more than 30% lipid as a proportion of the total volume were centrifuged. AmB-IL and AmB alone had similar in vitro antifungal activities against reference strains of yeasts. Further pharmacologic and clinical studies with AmB-IL are warranted, although AmB should not be combined with IL in concentrations capable of producing a precipitate.

Comparison of the in vitro antifungal activity of free and liposome-encapsulated amphotericin B

1991 ◽  
Vol 10 (8) ◽  
pp. 665-668 ◽  
Author(s):  
E. Anaissie ◽  
V. Paetznick ◽  
R. Proffitt ◽  
J. Adler-Moore ◽  
G. P. Bodey
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
In Vitro Antifungal Activity

scholarly journals Antifungal Activity of Amphotericin B, Fluconazole, and Voriconazole in an In Vitro Model of Candida Catheter-Related Bloodstream Infection

2002 ◽  
Vol 46 (11) ◽  
pp. 3499-3505 ◽  
Author(s):  
Russell E. Lewis ◽  
Dimitrios P. Kontoyiannis ◽  
Rabih O. Darouiche ◽  
Issam I. Raad ◽  
Randall A. Prince
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Venous Catheter ◽  
Central Venous Catheters ◽  
Pharmacodynamic Model ◽  
Central Venous ◽  
Single Lumen ◽  
Vitro Model ◽  
In Vitro Antifungal Activity

ABSTRACT The activity of five simulated antifungal regimens for eradication of catheter-related bloodstream Candida infection was evaluated with an in vitro pharmacodynamic model. Single-lumen central venous catheters were colonized with Candida species by sequentially incubating central venous catheters in plasma and then in growth medium (RPMI plus morpholinepropanesulfonic acid) containing a standardized suspension (105 CFU/ml) of Candida albicans, Candida glabrata, or slime-producing Candida parapsilosis. Colonized central venous catheters were then placed in a one-compartment pharmacodynamic model where five antifungal regimens (plus control) were simulated: amphotericin B, 1.0 mg/kg every 24 h; amphotericin B, 0.5 mg/kg every 24 h; fluconazole, 400 mg every 24 h; fluconazole, 800 mg every 24 h; and voriconazole, 4 mg/kg every 12 h. During exposure to the simulated clinical regimens, samples were serially removed from the model over 48 h for quantitation of viable organisms. All antifungal regimens suppressed fungal counts by both peripheral and catheter sampling versus control (P = 0.001). Overall, antifungal activity ranked amphotericin B (1 mg/kg) > amphotericin B (0.5 mg/kg) ≥ voriconazole > fluconazole (800 mg) ≥ fluconazole (400 mg). No regimen, however, completely eradicated (by culture and electron microscopy) central venous catheter colonization. Regrowth was noted in the model during therapy against C. glabrata and C. parapsilosis but was not associated with an increase in the MICs for the isolates. Lack of in vitro antifungal activity against biofilm-encased organisms appeared to be the primary reason for mycological failure of antifungal regimens in the model.

In vitro antifungal activity of phenothiazines and their combination with amphotericin B against different Candida species

Mycoses ◽  
2011 ◽  
Vol 54 (6) ◽  
pp. e737-e743 ◽  
Author(s):  
László Galgóczy ◽  
Andrea Bácsi ◽  
Mónika Homa ◽  
Máté Virágh ◽  
Tamás Papp ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Candida Species ◽  
In Vitro Antifungal Activity

Comparative in vitro Antifungal Activity of Amphotericin B Lipid Complex, Amphotericin B and Fluconazole

Chemotherapy ◽  
2000 ◽  
Vol 46 (4) ◽  
pp. 235-244 ◽  
Author(s):  
Alfonso-Javier Carrillo-Muñoz ◽  
Guillermo Quindós ◽  
Cristina Tur ◽  
Maite Ruesga ◽  
Rocío Alonso ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Lipid Complex ◽  
Amphotericin B Lipid Complex ◽  
In Vitro Antifungal Activity

scholarly journals Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity

Química Nova ◽  
2008 ◽  
Vol 31 (3) ◽  
pp. 591-594 ◽  
Author(s):  
Fabíola Branco Filippin ◽  
Liliete Canes Souza ◽  
Raul Cavalcante Maranhão
Keyword(s):  
Antifungal Activity ◽  
Amphotericin B ◽  
Stability Studies ◽  
In Vitro Antifungal Activity
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