scholarly journals 4-Hydroxybenzoic acid is a diffusible factor that connects metabolic shikimate pathway to the biosynthesis of a unique antifungal metabolite inLysobacter enzymogenes

2017 ◽  
Vol 104 (1) ◽  
pp. 163-178 ◽  
Author(s):  
Zhenhe Su ◽  
Hongfu Chen ◽  
Ping Wang ◽  
Simon Tombosa ◽  
Liangcheng Du ◽  
...  
Keyword(s):  
Shikimate Pathway ◽  
Hydroxybenzoic Acid ◽  
Antifungal Metabolite ◽  
Diffusible Factor

scholarly journals The diffusible factor synthase XanB2 is a bifunctional chorismatase that links the shikimate pathway to ubiquinone and xanthomonadins biosynthetic pathways

2012 ◽  
Vol 87 (1) ◽  
pp. 80-93 ◽  
Author(s):  
Lian Zhou ◽  
Jia-Yuan Wang ◽  
Jianhe Wang ◽  
Alan Poplawsky ◽  
Shuangjun Lin ◽  
...  
Keyword(s):  
Shikimate Pathway ◽  
Biosynthetic Pathways ◽  
Diffusible Factor

ChemInform Abstract: Formation of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC7N Units in Ansamycin Antibiotics, by a New Variant of the Shikimate Pathway.

ChemInform ◽  
2010 ◽  
Vol 23 (37) ◽  
pp. no-no
Author(s):  
C.-G. KIM ◽  
A. KIRSCHNING ◽  
P. BERGON ◽  
Y. AHN ◽  
J. J. WANG ◽  
...  
Keyword(s):  
Shikimate Pathway ◽  
Hydroxybenzoic Acid ◽  
New Variant

Formation of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway

1992 ◽  
Vol 114 (12) ◽  
pp. 4941-4943 ◽  
Author(s):  
C. G. Kim ◽  
A. Kirschning ◽  
P. Bergon ◽  
Y. Ahn ◽  
J. J. Wang ◽  
...  
Keyword(s):  
Shikimate Pathway ◽  
Hydroxybenzoic Acid ◽  
New Variant

scholarly journals Xanthomonas campestris Diffusible Factor Is 3-Hydroxybenzoic Acid and Is Associated with Xanthomonadin Biosynthesis, Cell Viability, Antioxidant Activity, and Systemic Invasion

2011 ◽  
Vol 24 (8) ◽  
pp. 948-957 ◽  
Author(s):  
Ya-Wen He ◽  
Ji'en Wu ◽  
Lian Zhou ◽  
Fan Yang ◽  
Yong-Qiang He ◽  
...  
Keyword(s):  
High Performance ◽  
Xanthomonas Campestris ◽  
Bacterial Species ◽  
In Silico Analysis ◽  
Structural Features ◽  
Flash Chromatography ◽  
Hydroxyl Group ◽  
Hydroxybenzoic Acid ◽  
Bacterial Survival ◽  
Diffusible Factor

Xanthomonas campestris pv. campestris produces a membrane-bound yellow pigment called xanthomonadin. A diffusible factor (DF) has been reported to regulate xanthomonadin biosynthesis. In this study, DF was purified from bacterial culture supernatants using a combination of solvent extraction, flash chromatography, and high-performance liquid chromatography. Mass spectrometry and nuclear magnetic resonance analyses resolved the DF chemical structure as 3-hydroxybenzoic acid (3-HBA), which was further confirmed by synthetic 3-HBA. Significantly, bioassay and in silico analysis suggest that DF production is widely conserved in a range of bacterial species. Analysis of DF derivatives established the hydroxyl group and its position as the key structural features for the role of DF in xanthomonadin biosynthesis. In addition, we showed that DF is also associated with bacterial survival, H2O2 resistance, and systemic invasion. Furthermore, evidence was also presented that DF and diffusible signaling factor have overlapping functions in modulation of bacterial survival, H2O2 resistance, and virulence. Utilization of different mechanisms to modulate similar virulence traits may provide X. campestris pv. campestris with plasticity in response to various environmental cues.

Biosynthesis of naphthomycin A in Streptomyces collinus

1994 ◽  
Vol 72 (1) ◽  
pp. 182-187 ◽  
Author(s):  
Jonathan P. Lee ◽  
Sheng-Wan Tsao ◽  
Ching-Jer Chang ◽  
Xian-Guo He ◽  
Heinz G. Floss
Keyword(s):  
Shikimate Pathway ◽  
Chain Extension ◽  
Hydroxybenzoic Acid ◽  
Nmr Analysis ◽  
Streptomyces Collinus ◽  
Feeding Experiments ◽  
Starter Unit ◽  
Rifamycin B ◽  
C Nmr

The biosynthesis of naphthomycin A (1) in Streptomyces collinus was studied in feeding experiments with single and multiple 13C-labeled precursors followed by 13C NMR analysis of the labeling and 13C–13C coupling patterns in the product. The results indicate that 1 is assembled via the polyketide pathway from 3-amino-5-hydroxybenzoic acid (2) as the starter unit (mC7N unit) plus seven propionate and six acetate chain extension units. 2 is synthesized via the shikimate pathway by a process that attaches the nitrogen to the carbon derived from C1 of erythrose 4-phosphate, consistent with a new branch of the shikimate pathway recently discovered to operate in the biosynthesis of the mC7N unit of rifamycin B.

Biotransformation of 4-hydroxybenzoic acid in the rhizosphere of grapevine (Vitis vinifera L.)

2017 ◽  
Vol 40 (1) ◽  
pp. 95-102 ◽  
Author(s):  
B. Wang ◽  
T. Zhou1 ◽  
K. Li ◽  
X.W. Guo ◽  
Y.S. Guo ◽  
...  
Keyword(s):  
Vitis Vinifera ◽  
Vitis Vinifera L ◽  
Hydroxybenzoic Acid

Synthesis and Evaluation of Aromatic Surfactants as Potential Antibacterial and Cytotoxic Agents

2019 ◽  
Vol 16 (6) ◽  
pp. 478-484
Author(s):  
Kenia Barrantes ◽  
Mary Fuentes ◽  
Luz Chacón ◽  
Rosario Achí ◽  
Jorge Granados-Zuñiga ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Hela Cells ◽  
Cytotoxic Agents ◽  
Cytotoxic Activities ◽  
Hydroxybenzoic Acid ◽  
Derivatives Of

Two ether and one ester derivatives of the 4-nitro-3-hydroxybenzoic acid were synthesized and characterized. The in vitro antimicrobial and cytotoxic activities of the three novel compounds were also evaluated. The aromatic derivatives showed antibacterial activity against one of the four microorganisms tested and two compounds (C8 and NOBA) had a lower IC50 in HeLa cells.

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