scholarly journals The cerebral microvasculature: Basic and clinical perspectives on stroke and glioma

2020 ◽  
Author(s):  
Maruf M. Hoque ◽  
Hanaa Abdelazim ◽  
Clifton Jenkins‐Houk ◽  
Dawn Wright ◽  
Biraj M. Patel ◽  
...  
Keyword(s):  
Cerebral Microvasculature

The Effect of Hypercholesterolemia on the Characteristics of Cerebral Microvasculature

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 463-P
Author(s):  
YUSUKE TODATE ◽  
YASUSHI ISHIGAKI
Keyword(s):  
Cerebral Microvasculature

Effects of Perfluorocarbon Dodecafluoropentane (NVX-108) on Cerebral Microvasculature in the Healthy Rat

2014 ◽  
Vol 11 (3) ◽  
pp. 220-226 ◽  
Author(s):  
Paula Moon-Massat ◽  
Rania Abutarboush ◽  
Georgina Pappas ◽  
Ashraful Haque ◽  
Chioma Aligbe ◽  
...  
Keyword(s):  
Cerebral Microvasculature

scholarly journals Non-productive angiogenesis disassembles Aß plaque-associated blood vessels

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Maria I. Alvarez-Vergara ◽  
Alicia E. Rosales-Nieves ◽  
Rosana March-Diaz ◽  
Guiomar Rodriguez-Perinan ◽  
Nieves Lara-Ureña ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Vessels ◽  
Molecular Signature ◽  
Loss Of Function ◽  
Local Loss ◽  
Microglial Phagocytosis ◽  
Vascular Phenotype ◽  
Cerebral Microvasculature ◽  
Vascular Component

AbstractThe human Alzheimer’s disease (AD) brain accumulates angiogenic markers but paradoxically, the cerebral microvasculature is reduced around Aß plaques. Here we demonstrate that angiogenesis is started near Aß plaques in both AD mouse models and human AD samples. However, endothelial cells express the molecular signature of non-productive angiogenesis (NPA) and accumulate, around Aß plaques, a tip cell marker and IB4 reactive vascular anomalies with reduced NOTCH activity. Notably, NPA induction by endothelial loss of presenilin, whose mutations cause familial AD and which activity has been shown to decrease with age, produced a similar vascular phenotype in the absence of Aß pathology. We also show that Aß plaque-associated NPA locally disassembles blood vessels, leaving behind vascular scars, and that microglial phagocytosis contributes to the local loss of endothelial cells. These results define the role of NPA and microglia in local blood vessel disassembly and highlight the vascular component of presenilin loss of function in AD.

Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels

1988 ◽  
Vol 254 (3) ◽  
pp. E272-E278
Author(s):  
A. L. McCall ◽  
I. Sussman ◽  
K. Tornheim ◽  
R. Cordero ◽  
N. B. Ruderman
Keyword(s):  
Glucose Metabolism ◽  
Glucose Oxidation ◽  
Cerebral Microvessels ◽  
Fuel Metabolism ◽  
Brain Microvessels ◽  
Cerebral Microvasculature ◽  
Streptozotocin Induced Diabetes ◽  
Consistent Increase ◽  
Beta Hydroxybutyrate ◽  
Cerebral Microvessel

Glucose and beta-hydroxybutyrate metabolism were compared in isolated cerebral microvessels from chronically diabetic and hypoglycemic rats. As noted previously, glucose oxidation and conversion to lactate are diminished in rats with streptozotocin-induced diabetes. The decrease in glucose metabolism did not result from selective damage to diabetic vessels during isolation, since the ATP level and the ATP/ADP ratio were similar to those of nondiabetic rats, and O2 consumption was increased. In addition, cerebral microvessel oxidation of beta-hydroxybutyrate was enhanced by diabetes. By contrast, microvessels from rats made chronically hypoglycemic by insulinoma engrafting 30 days earlier had a more than twofold increase in glucose oxidation and conversion to lactate, whereas their oxidation of beta-hydroxybutyrate was diminished by 50%. Unlike the insulinoma rats, no consistent increase in glucose metabolism was observed in microvessels from rats made hypoglycemic either by acute insulin administration or by a 4-day infusion of insulin. These results indicate that diabetes, and under some circumstances chronic hypoglycemia, markedly alters fuel metabolism in the cerebral microvasculature.

Sign in / Sign up

Export Citation Format

Share Document