The relationship between forearm skin speed-resolved perfusion and oxygen saturation, and finger arterial pulsation amplitudes, as indirect measures of endothelial function

2018 ◽  
Vol 25 (2) ◽  
pp. e12422
Author(s):  
Sara Bergstrand ◽  
Maria-Aurora Morales ◽  
Giuseppe Coppini ◽  
Marcus Larsson ◽  
Tomas Strömberg
Keyword(s):  
Endothelial Function ◽  
Oxygen Saturation ◽  
Indirect Measures ◽  
Forearm Skin ◽  
Arterial Pulsation ◽  
The Relationship

Effect of subcutaneous arterial pulsation on determination of cerebral arterial oxygen saturation using NIRS

2000 ◽  
Author(s):  
Ralph J. F. Houston ◽  
Jan Menssen ◽  
Marco C. van der Sluijs ◽  
Willy N. Colier ◽  
Berend Oeseburg
Keyword(s):  
Oxygen Saturation ◽  
Arterial Oxygen Saturation ◽  
Arterial Oxygen ◽  
Arterial Pulsation

scholarly journals The relationship of pro-inflammatory markers to vascular endothelial function after acute stroke

2016 ◽  
Vol 127 (6) ◽  
pp. 486-492 ◽  
Author(s):  
Sandra A Billinger ◽  
Jason-Flor V Sisante ◽  
Anna E Mattlage ◽  
Abdulfattah S Alqahtani ◽  
Michael G Abraham ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Acute Stroke ◽  
Inflammatory Markers ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Relationship Of ◽  
The Relationship

scholarly journals Evaluating Kupferstein’s claims of the relationship of behavioral intervention to PTSS for individuals with autism

2018 ◽  
Vol 4 (3) ◽  
pp. 122-129 ◽  
Author(s):  
Justin Barrett Leaf ◽  
Robert K. Ross ◽  
Joseph H. Cihon ◽  
Mary Jane Weiss
Keyword(s):  
Stress Disorder ◽  
Service Providers ◽  
Extreme Caution ◽  
Content Type ◽  
Diagnostic Threshold ◽  
Indirect Measures ◽  
Methodological Rigor ◽  
Relationship Of ◽  
The Relationship ◽  
Selection Of

Purpose Kupferstein (2018) surveyed 460 respondents and found that 46 percent of respondents met the diagnostic threshold for posttraumatic stress disorder after exposure to applied-behavior-analysis-based intervention. The purpose of this paper is to provide an evaluation a critical analysis of Kupferstein (2018) including the experimental methods and discussion of the results. Design/methodology/approach The authors evaluated the Kupferstein’s methodological rigor with respect to the use of hypothesis testing, use of indirect measures, selection of respondents, ambiguity in definitions, measurement system, and framing of the experimental question when conducting the correlational analysis in addition to Kupferstein’s analysis and discussion of the results. Findings Based upon the analysis, Kupferstein’s results should be viewed with extreme caution due to several methodological and conceptual flaws including, but not limited to, leading questions used within a non-validated survey, failure to confirm diagnosis, and incomplete description of interventions. Originality/value It is the authors’ hope that this analysis provides caregivers, clinicians, and service providers with a scientific lens which will useful in viewing the limitations and methodological flaws of Kupferstein.

scholarly journals Mummy, Daddy, and Addiction: Implicit Insecure Attachment is Associated with Substance Use in College Students

2019 ◽  
Author(s):  
Wilfried Serra ◽  
Armand Chatard ◽  
Nina Tello ◽  
Ghina Harika-Germaneau ◽  
Xavier Noël ◽  
...  
Keyword(s):  
College Students ◽  
Substance Use ◽  
Attachment Styles ◽  
Addictive Behaviors ◽  
Indirect Measures ◽  
Adult Attachment Styles ◽  
Single Category ◽  
Two Measures ◽  
Past Experiences ◽  
The Relationship

Indirect measures of cognition have become an important tool in research on addiction. To date, however, no research has examined whether indirect measures of parent attachment relate to substance use. To examine this issue, a sample of college students (N = 121) was asked to complete two measures of explicit attachment (the Relationship Questionnaire; Bartholomew & Horowitz, 1991, and the Adult Attachment Styles; Collins & Read, 1990), and a measure of implicit attachment (the Single Category Implicit Association Test, Karpinski & Steinman, 2006). The indirect attachment measure assessed the strength of automatic mental association between the concepts parents and secure. Participants also completed different measures of tobacco, cannabis, and alcohol use. Results showed that, for most of the participants, the parents were considered a source of security at both the explicit and implicit levels. Direct and indirect attachment measures were not related to each other. Overall, explicit attachment was not related to substance use. However, implicit attachment was significantly associated with the use of licit (tobacco) and illicit (cannabis) drugs. We also found some evidence that polydrug use is especially common among students with an insecure implicit attachment. This is the first study to examine how implicit attachment processes relate to addictive behaviors. The results suggest that implicit attachment, thought to reflect unconscious traces of past experiences, is a better predictor of substance use in college students than direct, self-reported measures of attachment. Further studies should examine whether implicit attachment is associated with severe substance use disorders in clinical populations.

scholarly journals Relationship Between Occlusal Force and Endothelial Function in Community-Dwelling Elderly

2020 ◽  
Author(s):  
Kanna Kato ◽  
Naoko Matsuda ◽  
Miki Takahata ◽  
Chika Koseki ◽  
Michiyasu Yamaki ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Endothelial Function ◽  
Grip Strength ◽  
General Condition ◽  
Force Measurement ◽  
The Elderly ◽  
Community Dwelling ◽  
Healthy Life ◽  
Occlusal Force ◽  
The Relationship

Abstract Background: Prolonged healthy life expectancy, which is duration without the requirement of any kind of help for activities of daily living (ADL), is essential to ensure a long life with a good quality of living in the community. Further, local residents should understand their health conditions and live consciously to prolong healthy life expectancy. The development of a simple general health indicator is necessary. Both occlusal force and flow-medicated dilation (FMD) which reflects endothelial function are useful tools for understanding the general condition of the elderly. However, few studies have investigated the relationship between occlusal force and endothelial function. In the present study we examined this relationship, occlusal force measurement can be a good indicator of the general condition of the elderly. Methods: In 38 community-dwelling women(aged 76.7 ±5.7 years), we measured occlusal force,　grip strength, endothelial function evaluated by FMD, advanced glycation end products (AGEs). In this study we investigate we investigated the relationship between occlusal force, measurement items, and factors independently related to endothelial dysfunction (FMD<7％). Results: There were significantly correlation between occlusal force and grip strength (r=0.54, p<0.01). Degree of FMD significantly associated with occlusal force (r=0.60, p<0.01) and grip strength (r=0.35, p<0.05) or amount of increased AGEs (r=-0.37, p<0.05). Occlusal force was independently associated with degree of FMD after adjusting for age, AGEs, and grip strength (p < 0.05).Conclusion: There was a significant relationship between occlusal force and FMD. Occlusal force can be an important indicator of endothelial function in community-dwelling elderly. This study may help understanding general health of elderly in community.

scholarly journals SIMULATION OF THE RELATIONSHIP BETWEEN EXERCISE AND CARDIOPULMONARY FUNCTION AT HIGH ALTITUDE

2021 ◽  
Vol 27 (5) ◽  
pp. 509-513
Author(s):  
Rui Li
Keyword(s):  
Heart Rate ◽  
Arterial Pressure ◽  
Oxygen Saturation ◽  
High Altitude ◽  
Lower Limb ◽  
Pulmonary Circulation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Cardiopulmonary Function ◽  
The Relationship

ABSTRACT Introduction: Due to various uncertain and unexpected factors in life such as diseases, natural disasters, traffic accidents, and congenital disabilities, the number and proportion of lower limb amputations are still rising for many reasons, so the research on lower limb prostheses is particularly important. Objective: This work aimed to study the relationship between altitude exercise and cardiopulmonary function. Methods: A model of abnormal changes in cardiopulmonary function was established, and then 40 plateau exercisers were selected, all of whom arrived in Tibet in March 2017. The relationship between pulmonary circulation volume and internal pressure in the chest was observed and compared. The relationship between cardiopulmonary sensory reflex and exercise (high altitude) breathing and heart rate was analyzed. A comparison of the cardiopulmonary function of subjects of different genders was implemented. Moreover, the influence of different altitudes on the subjects’ cardiopulmonary function and the subjects’ cardiopulmonary function changes before departure and during the first, second, and third week after departure were observed and compared. Results: I. As the pressure in the thoracic cavity increased, the subjects’ pulmonary circulation blood volume gradually decreased, and the decrease was most obvious in the stage of thoracic pressure −50 to 0. II. As the cardiorespiratory reflex coefficient increased, the subjects’ breathing and heart rate compensatory acceleration appeared. III. Tracking and monitoring of the subjects’ cardiopulmonary indicators revealed that with the increase in altitude, the subjects’ average arterial pressure, respiratory frequency, and heart rate all showed an upward trend, while the blood oxygen saturation value showed a downward trend. IV. No matter how high the altitude was, the average arterial pressure, respiratory rate, and heart rate monitored of the subjects under exercise were significantly superior to the indicator values under resting state. In contrast, the blood oxygen saturation value showed the opposite trend. V. The subjects’ average arterial pressure, respiration, and heart rate in the first week were higher than other periods, but the blood oxygen saturation was relatively lower. In the second and third weeks, the changes in cardiopulmonary function were relatively smooth (all P<0.05). VI. The changes in the index of the cardiopulmonary function of subjects of different genders were small (p>0.05). Conclusion: Through modeling, the results of the plateau environment on the cardiopulmonary function of the body were made clearer, and these research data provided theoretical references for the training of the sports field in the plateau area. Level of evidence II; Therapeutic studies - investigation of treatment results.

scholarly journals The effects of cannabis use on salience attribution: a systematic review

2016 ◽  
Vol 30 (1) ◽  
pp. 43-57 ◽  
Author(s):  
Surapi Bhairavi Wijayendran ◽  
Aisling O’Neill ◽  
Sagnik Bhattacharyya
Keyword(s):  
Brain Regions ◽  
Cannabis Use ◽  
Cognitive Tasks ◽  
Indirect Measures ◽  
Neural Processes ◽  
Aberrant Salience ◽  
And Performance ◽  
The Relationship ◽  
Chronic Use

ObjectiveThe relationship between cannabis use and the onset of psychosis is well established. Aberrant salience processing is widely thought to underpin many of these symptoms. Literature explicitly investigating the relationship between aberrant salience processing and cannabis use is scarce; with those few studies finding that acute tetrahydrocannabinol (THC) administration (the main psychoactive component of cannabis) can result in abnormal salience processing in healthy cohorts, mirroring that observed in psychosis. Nevertheless, the extent of and mechanisms through which cannabis has a modulatory effect on aberrant salience, following both acute and chronic use, remain unclear.MethodsHere, we systematically review recent findings on the effects of cannabis use – either through acute THC administration or in chronic users – on brain regions associated with salience processing (through functional MRI data); and performance in cognitive tasks that could be used as either direct or indirect measures of salience processing. We identified 13 studies either directly or indirectly exploring salience processing. Three types of salience were identified and discussed – incentive/motivational, emotional/affective, and attentional salience.ResultsThe results demonstrated an impairment of immediate salience processing, following acute THC administration. Amongst the long-term cannabis users, normal salience performance appeared to be underpinned by abnormal neural processes.ConclusionsOverall, the lack of research specifically exploring the effects of cannabis use on salience processing, weaken any conclusions drawn. Additional research explicitly focussed on salience processing and cannabis use is required to advance our understanding of the neurocognitive mechanisms underlying the association between cannabis use and development of psychosis.

scholarly journals Relating oxygen partial pressure, saturation and content: the haemoglobin–oxygen dissociation curve

Breathe ◽  
2015 ◽  
Vol 11 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Julie-Ann Collins ◽  
Aram Rudenski ◽  
John Gibson ◽  
Luke Howard ◽  
Ronan O’Driscoll
Keyword(s):  
Oxygen Saturation ◽  
Partial Pressure ◽  
Pulse Oximetry ◽  
Blood Gas Analysis ◽  
Gas Analysis ◽  
Oxygen Dissociation Curve ◽  
Blood Gas ◽  
Dissociation Curve ◽  
Oxygen Dissociation ◽  
The Relationship

Key PointsIn clinical practice, the level of arterial oxygenation can be measured either directly by blood gas sampling to measure partial pressure (PaO2) and percentage saturation (SaO2) or indirectly by pulse oximetry (SpO2).This review addresses the strengths and weaknesses of each of these tests and gives advice on their clinical use.The haemoglobin–oxygen dissociation curve describing the relationship between oxygen partial pressure and saturation can be modelled mathematically and routinely obtained clinical data support the accuracy of a historical equation used to describe this relationship.Educational AimsTo understand how oxygen is delivered to the tissues.To understand the relationships between oxygen saturation, partial pressure, content and tissue delivery.The clinical relevance of the haemoglobin–oxygen dissociation curve will be reviewed and we will show how a mathematical model of the curve, derived in the 1960s from limited laboratory data, accurately describes the relationship between oxygen saturation and partial pressure in a large number of routinely obtained clinical samples.To understand the role of pulse oximetry in clinical practice.To understand the differences between arterial, capillary and venous blood gas samples and the role of their measurement in clinical practice.The delivery of oxygen by arterial blood to the tissues of the body has a number of critical determinants including blood oxygen concentration (content), saturation (SO2) and partial pressure, haemoglobin concentration and cardiac output, including its distribution. The haemoglobin–oxygen dissociation curve, a graphical representation of the relationship between oxygen satur­ation and oxygen partial pressure helps us to understand some of the principles underpinning this process. Historically this curve was derived from very limited data based on blood samples from small numbers of healthy subjects which were manipulated in vitro and ultimately determined by equations such as those described by Severinghaus in 1979. In a study of 3524 clinical specimens, we found that this equation estimated the SO2 in blood from patients with normal pH and SO2 >70% with remarkable accuracy and, to our knowledge, this is the first large-scale validation of this equation using clinical samples. Oxygen saturation by pulse oximetry (SpO2) is nowadays the standard clinical method for assessing arterial oxygen saturation, providing a convenient, pain-free means of continuously assessing oxygenation, provided the interpreting clinician is aware of important limitations. The use of pulse oximetry reduces the need for arterial blood gas analysis (SaO2) as many patients who are not at risk of hypercapnic respiratory failure or metabolic acidosis and have acceptable SpO2 do not necessarily require blood gas analysis. While arterial sampling remains the gold-standard method of assessing ventilation and oxygenation, in those patients in whom blood gas analysis is indicated, arterialised capillary samples also have a valuable role in patient care. The clinical role of venous blood gases however remains less well defined.

Assessment of microvascular endothelial function in human skin

2001 ◽  
Vol 101 (6) ◽  
pp. 567-572 ◽  
Author(s):  
David J. NEWTON ◽  
Faisel KHAN ◽  
Jill J.F. BELCH
Keyword(s):  
Blood Flow ◽  
Substance P ◽  
Endothelial Function ◽  
Animal Studies ◽  
Doppler Imaging ◽  
Microvascular Blood Flow ◽  
Coefficients Of Variation ◽  
Forearm Skin ◽  
Invasive Techniques ◽  
Dose Dependent

Endothelial dysfunction is an important factor in many cardiovascular diseases, and is commonly associated with impaired endothelium-mediated vasodilatation. Information about the mechanisms behind this dysfunction has come largely from animal studies or, in humans, through invasive techniques that are not specific to one vascular bed. We have developed protocols to assess endothelial function non-invasively in the cutaneous microcirculation by measuring blood flow responses to four receptor-specific vasoactive compounds. Cumulative doses of acetylcholine, methacholine, bradykinin and substance P were administered iontophoretically to the forearm skin of healthy volunteers on two to three occasions. Dose-dependent increases in skin microvascular blood flow in response to these drugs were measured with laser Doppler imaging. Vascular responses to acetylcholine and methacholine were reasonably consistent, with coefficients of variation of approx. 17%. The coefficients of variation for bradykinin and substance P were much poorer, as high as 70% for some doses. This might partly be a consequence of the more unpredictable effects of histamine release in the vasoactive behaviour of these two agonists. Although it might be advantageous to find other agonists with which to test the function of different receptor pathways, we have shown that just acetylcholine and methacholine can currently be used with iontophoresis to allow sensitive and reproducible assessment of endothelial function.

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