Gene expression plasticity evolves in response to colonization of freshwater lakes in threespine stickleback

2014 ◽  
Vol 23 (13) ◽  
pp. 3226-3240 ◽  
Author(s):  
Matthew R. J. Morris ◽  
Romain Richard ◽  
Erica H. Leder ◽  
Rowan D. H. Barrett ◽  
Nadia Aubin-Horth ◽  
...  
Keyword(s):  
Gene Expression ◽  
Threespine Stickleback ◽  
Freshwater Lakes

scholarly journals Early Life Disruption of the Microbiota Affects Organ Development and Cytokine Gene Expression in Threespine Stickleback

2020 ◽  
Author(s):  
Lucas J Kirschman ◽  
Anastasia Khadjinova ◽  
Kelly Ireland ◽  
Kathryn C Milligan-Myhre
Keyword(s):  
Gene Expression ◽  
Early Life ◽  
Genetic Background ◽  
Gasterosteus Aculeatus ◽  
Threespine Stickleback ◽  
Microbial Colonization ◽  
Cytokine Gene Expression ◽  
Immune Gene ◽  
Cytokine Gene

Synopsis The microbiota that inhabits vertebrates exerts strong effects on host physiology and can be crucial to the development of a normal phenotype. This includes development of the immune system, somatic growth and maintenance, and morphogenesis. However, the genetic background of the host can also affect these life history traits. To this end, we investigated the effects of the microbiota on growth, development, and immune gene expression on two populations of threespine stickleback (Gasterosteus aculeatus), one anadromous and one freshwater. We tested the hypotheses that microbial colonization and the genetic background of the host would affect survival, cytokine gene expression, growth, and development. We raised in vitro crosses of stickleback larvae with and without conventional microbiota. We then exposed all these treatments to Vibrio anguillarum, a potential fish pathogen, in a full factorial design. We found stickleback raised without conventional microbiota had smaller swim bladders relative to those raised with conventional microbiota. Stickleback raised with conventional microbiota exhibited small increases in cytokine gene expression. We found no differences in growth or survival regardless of treatment. These results are consistent with other investigations that show microbiota disruption, in early life, can alter host organ and tissue development and immune responses

scholarly journals Regulatory Architecture of Gene Expression Variation in the Threespine Stickleback Gasterosteus aculeatus

2016 ◽  
Vol 7 (1) ◽  
pp. 165-178 ◽  
Author(s):  
Victoria L. Pritchard ◽  
Heidi M. Viitaniemi ◽  
R. J. Scott McCairns ◽  
Juha Merilä ◽  
Mikko Nikinmaa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gasterosteus Aculeatus ◽  
Threespine Stickleback ◽  
Gene Expression Variation ◽  
Expression Variation ◽  
Regulatory Architecture

scholarly journals Evolution of a costly immunity to cestode parasites is a pyrrhic victory

2021 ◽  
Author(s):  
Jesse N Weber ◽  
Natalie C Steinel ◽  
Foen Peng ◽  
Kum Chuan Shim ◽  
Brian K Lohman ◽  
...  
Keyword(s):  
Immune Response ◽  
Population Genomics ◽  
Threespine Stickleback ◽  
Freshwater Lakes ◽  
Fitness Costs ◽  
Peritoneal Fibrosis ◽  
Substantial Cost ◽  
Schistocephalus Solidus ◽  
Loss Of Resistance ◽  
Pyrrhic Victory

Parasites impose fitness costs on their hosts. Biologists therefore tend to assume that natural selection favors infection-resistant hosts. Yet, when the immune response itself is costly, theory suggests selection may instead favor loss of resistance. Immune costs are rarely documented in nature, and there are few examples of adaptive loss of resistance. Here, we show that when marine threespine stickleback colonized freshwater lakes they gained resistance to the freshwater-associated tapeworm, Schistocephalus solidus. Extensive peritoneal fibrosis and inflammation contribute to suppression of cestode growth and viability, but also impose a substantial cost of reduced fecundity. Combining genetic mapping and population genomics, we find that the immune differences between tolerant and resistant populations arise from opposing selection in both populations acting, respectively, to reduce and increase resistance consistent with divergent optimization.

scholarly journals Between‐population differences in constitutive and infection‐induced gene expression in threespine stickleback

2021 ◽  
Author(s):  
Lauren E. Fuess ◽  
Jesse N. Weber ◽  
Stijn den Haan ◽  
Natalie C. Steinel ◽  
Kum Chuan Shim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Threespine Stickleback ◽  
Population Differences

scholarly journals Gene expression responses of threespine stickleback to salinity: implications for salt-sensitive hypertension

2014 ◽  
Vol 5 ◽  
Author(s):  
Gang Wang ◽  
Ence Yang ◽  
Kerri J. Smith ◽  
Yong Zeng ◽  
Guoli Ji ◽  
...  
Keyword(s):  
Gene Expression ◽  
Threespine Stickleback ◽  
Salt Sensitive Hypertension

scholarly journals Regulatory architecture of gene expression variation in the threespine stickleback, Gasterosteus aculeatus

2016 ◽  
Author(s):  
Victoria L. Pritchard ◽  
Heidi M. Viitaniemi ◽  
R.J. Scott McCairns ◽  
Juha Merilä ◽  
Mikko Nikinmaa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Regulatory Networks ◽  
Gasterosteus Aculeatus ◽  
Genotyping By Sequencing ◽  
Interval Mapping ◽  
Threespine Stickleback ◽  
Adaptive Divergence ◽  
Gene Expression Variation ◽  
Expression Variation ◽  
Regulatory Architecture

Much adaptive evolutionary change is underlain by mutational variation in regions of the genome that regulate gene expression rather than in the coding regions of the genes themselves. An understanding of the role of gene expression variation in facilitating local adaptation will be aided by an understanding of underlying regulatory networks. Here, we characterize the genetic architecture of gene expression variation in the threespine stickleback (Gasterosteus aculeatus), an important model in the study of adaptive evolution. We collected transcriptomic and genomic data from 60 half-sib families using an expression microarray and genotyping-by-sequencing, and located QTL underlying the variation in gene expression (eQTL) in liver tissue using an interval mapping approach. We identified eQTL for several thousand expression traits. Expression was influenced by polymorphism in both cis and trans regulatory regions. Trans eQTL clustered into hotspots. We did not identify master transcriptional regulators in hotspot locations: rather, the presence of hotspots may be driven by complex interactions between multiple transcription factors. One observed hotspot co-located with a QTL recently found to underlie salinity tolerance in the threespine stickleback. However, most other observed hotspots did not co-locate with regions of the genome known to be involved in adaptive divergence between marine and freshwater habitats.

Gene expression plasticity in response to salinity acclimation in threespine stickleback ecotypes from different salinity habitats

2017 ◽  
Vol 26 (10) ◽  
pp. 2711-2725 ◽  
Author(s):  
Taylor C. Gibbons ◽  
David C. H. Metzger ◽  
Timothy M. Healy ◽  
Patricia M. Schulte
Keyword(s):  
Gene Expression ◽  
Threespine Stickleback ◽  
Salinity Acclimation
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