scholarly journals Hepatic fat as clinical outcome and therapeutic target for nonalcoholic fatty liver disease

2018 ◽  
Vol 39 (2) ◽  
pp. 250-256 ◽  
Author(s):  
Serena Pelusi ◽  
Luca Valenti
Keyword(s):  
Liver Disease ◽  
Clinical Outcome ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Therapeutic Target ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat

Angiopoietin-2 Promotes Pathological Angiogenesis and Is a Therapeutic Target in Murine Nonalcoholic Fatty Liver Disease

Hepatology ◽  
2019 ◽  
Vol 69 (3) ◽  
pp. 1087-1104 ◽  
Author(s):  
Sander Lefere ◽  
Frederique Van de Velde ◽  
Anne Hoorens ◽  
Sarah Raevens ◽  
Sanne Van Campenhout ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Therapeutic Target ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Pathological Angiogenesis ◽  
Angiopoietin 2

An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase

2020 ◽  
Vol 319 (4) ◽  
pp. G469-G480
Author(s):  
Simone Carotti ◽  
Katia Aquilano ◽  
Francesco Valentini ◽  
Sergio Ruggiero ◽  
Francesca Alletto ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fat Metabolism ◽  
Special Focus ◽  
Acid Lipase ◽  
Nonalcoholic Fatty Liver ◽  
Lysosomal Acid ◽  
Hepatic Fat

Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver steatosis develops as a result of the deregulation of pathways controlling de novo lipogenesis and fat catabolism. Recent evidences suggest the clinical relevance of a reduction in the activity of lysosomal acid lipase (LAL), which is a key enzyme for intracellular fat disposal, in patients with NAFLD. In this review, we provided a comprehensive overview of the critical steps in hepatic fat metabolism and alterations in these pathways in NAFLD, with a special focus on lipophagy and LAL activity. During NAFLD, hepatic fat metabolism is impaired at several levels, which is significantly contributed to by impaired lipophagy, in which reduced LAL activity may play an important role. For further research and intervention in NAFLD, targeting LAL activity may provide interesting perspectives.

scholarly journals Quantification of Hepatic Fat Fraction in Patients With Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Qinhe Zhang ◽  
Ying Zhao ◽  
Jingjun Wu ◽  
Luhan Xie ◽  
Anliang Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat ◽  
Fat Fraction
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