scholarly journals Whole liver engineering: A promising approach to develop functional liver surrogates

2017 ◽  
Vol 37 (12) ◽  
pp. 1759-1772 ◽  
Author(s):  
Fanwei Meng ◽  
Abdallah Assiri ◽  
Dipok Dhar ◽  
Dieter Broering
Keyword(s):  
Liver Engineering

The Next Step in In-Vivo Liver Engineering: Generation of an In vivo Liver Lobe Scaffold Which is Structurally Intact and Physiologically Reperfusable

2019 ◽  
Author(s):  
An Wang ◽  
Olha Kuriata ◽  
Sandor Nietzsche ◽  
Felix Gremse ◽  
Utz Settmacher ◽  
...  
Keyword(s):  
Liver Lobe ◽  
Liver Engineering

scholarly journals A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

10.3791/57991 ◽  
2018 ◽  
Author(s):  
An Wang ◽  
Isabel Jank ◽  
Weiwei Wei ◽  
Claudia Schindler ◽  
Uta Dahmen
Keyword(s):  
Surgical Technique ◽  
Liver Engineering

Whole liver engineering

2012 ◽  
Vol 29 ◽  
pp. S32
Author(s):  
Basak E. Uygun ◽  
Yeonhee Kim ◽  
Tim Berendsen ◽  
Sinan Ozer ◽  
Martin L. Yarmush ◽  
...  
Keyword(s):  
Liver Engineering

Stem cells and liver engineering

2013 ◽  
Vol 31 (7) ◽  
pp. 1094-1107 ◽  
Author(s):  
Laura Ordovás ◽  
Yonsil Park ◽  
Catherine M. Verfaillie
Keyword(s):  
Stem Cells ◽  
Liver Engineering

Collagen Rich Scaffolds for Liver Engineering: A Step Forward to an Artificial Liver

2016 ◽  
Vol 6 ◽  
pp. S86-S87 ◽  
Author(s):  
Catherine Martin ◽  
R. Subathra ◽  
V. Jayanthi ◽  
Srinivas Reddy ◽  
Joy Varghese ◽  
...  
Keyword(s):  
Artificial Liver ◽  
Liver Engineering

„Liver engineering“ als neue Quelle von Spenderorganen

Der Chirurg ◽  
2015 ◽  
Vol 87 (6) ◽  
pp. 504-513 ◽  
Author(s):  
F. Mußbach ◽  
U. Dahmen ◽  
O. Dirsch ◽  
U. Settmacher
Keyword(s):  
Liver Engineering

scholarly journals Repopulation of intrahepatic bile ducts in engineered rat liver grafts

TECHNOLOGY ◽  
2019 ◽  
Vol 07 (01n02) ◽  
pp. 46-55
Author(s):  
Yibin Chen ◽  
Julie Devalliere ◽  
Beyza Bulutoglu ◽  
Martin L. Yarmush ◽  
Basak E. Uygun
Keyword(s):  
Epithelial Cells ◽  
Rat Liver ◽  
Bile Ducts ◽  
Hepatic Function ◽  
Large Animal ◽  
Biliary Epithelial Cells ◽  
Large Animal Models ◽  
Intrahepatic Bile Ducts ◽  
Liver Engineering ◽  
Decellularized Liver

Engineered liver grafts for transplantation with sufficient hepatic function have been developed both in small and large animal models using the whole liver engineering approach. However, repopulation of the bile ducts in the whole liver scaffolds has not been addressed yet. In this study, we show the feasibility of repopulating the bile ducts in decellularized rat livers. Biliary epithelial cells were introduced into the bile ducts of the decellularized liver scaffolds with or without hepatocytes in the parenchymal space. The recellularized grafts were cultured under perfusion for up to 2 days and histological analysis revealed that the biliary epithelial cells formed duct-like structures, with the viable hepatocyte mass residing in the parenchymal space, in an arrangement highly comparable to the native tissue. The grafts were viable and functional as confirmed by both albumin and urea assay results and the gene expression analysis of biliary epithelial cells in recellularized liver grafts. This study provides the proof-of-concept results for rat liver grafts co-populated with parenchymal and biliary epithelial cells.

scholarly journals An In Vitro Whole-Organ Liver Engineering for Testing of Genetic Therapies

iScience ◽  
2020 ◽  
Vol 23 (12) ◽  
pp. 101808
Author(s):  
Maëlle Lorvellec ◽  
Alessandro Filippo Pellegata ◽  
Alice Maestri ◽  
Chiara Turchetta ◽  
Elena Alvarez Mediavilla ◽  
...  
Keyword(s):  
Liver Engineering

A Survival Model of In Vivo Partial Liver Lobe Decellularization Towards In Vivo Liver Engineering

2020 ◽  
Vol 26 (8) ◽  
pp. 402-417 ◽  
Author(s):  
An Wang ◽  
Olha Kuriata ◽  
Fengming Xu ◽  
Sandor Nietzsche ◽  
Felix Gremse ◽  
...  
Keyword(s):  
Survival Model ◽  
Liver Lobe ◽  
Liver Engineering
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