A Survival Model of In Vivo Partial Liver Lobe Decellularization Towards In Vivo Liver Engineering

2020 ◽  
Vol 26 (8) ◽  
pp. 402-417 ◽  
Author(s):  
An Wang ◽  
Olha Kuriata ◽  
Fengming Xu ◽  
Sandor Nietzsche ◽  
Felix Gremse ◽  
...  
Keyword(s):  
Survival Model ◽  
Liver Lobe ◽  
Liver Engineering

The Next Step in In-Vivo Liver Engineering: Generation of an In vivo Liver Lobe Scaffold Which is Structurally Intact and Physiologically Reperfusable

2019 ◽  
Author(s):  
An Wang ◽  
Olha Kuriata ◽  
Sandor Nietzsche ◽  
Felix Gremse ◽  
Utz Settmacher ◽  
...  
Keyword(s):  
Liver Lobe ◽  
Liver Engineering

scholarly journals In Vivo Evaluation of Customized Aortic Repair Using a Novel Survival Model

2016 ◽  
Vol 52 (2) ◽  
pp. 166-172 ◽  
Author(s):  
B.M. Doorschodt ◽  
H.L. Brom ◽  
A.C. de Vries ◽  
C. Meers ◽  
M.J. Jacobs
Keyword(s):  
Survival Model ◽  
In Vivo Evaluation ◽  
Aortic Repair

scholarly journals Discrete Survival Model Analysis of Plasmodium falciparum Response to Artemisinin-Based Combination Therapies among Children in Regions of Varying Malaria Transmission in Cameroon

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1106
Author(s):  
Akindeh M. Nji ◽  
Innocent M. Ali ◽  
Peter Thelma Ngwa Niba ◽  
Evehe Marie-Solange ◽  
Christian Heumann ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Current Practice ◽  
Parasite Clearance ◽  
Serum Levels ◽  
Step Function ◽  
Survival Model ◽  
Combination Therapies ◽  
Older Children ◽  
Pretreatment Serum

The need to monitor changes in parasite clearance following treatment with artemisinin-based combination therapies (ACTs) is important in the containment of drug resistance. This study aimed to model Plasmodium falciparum response to ACTs among children in two different transmission settings (Mutengene and Garoua) in Cameroon. Using the step function, a discrete-time survival model was fitted with all the covariates included that might play a role in parasite clearance. The probability of clearing parasites within 24 h following treatment was 21.6% and 70.3% for younger children aged 6 to 59 months and 29.3% and 59.8% for older children aged 60 to 120 months in Mutengene and Garoua, respectively. After two days of treatment, the conditional probability of clearing parasites given that they were not cleared on day 1 was 76.7% and 96.6% for children aged 6–59 months and 83.1% and 93.5% for children aged 60–120 months in Mutengene and Garoua, respectively. The model demonstrated that the ecological setting, age group and pretreatment serum levels of creatinine and alanine aminotransferase were the main factors that significantly influenced parasite clearance in vivo after administration of ACTs (p < 0.05). The findings highlight the need for further investigations on host differential response to ACTs in current practice.

scholarly journals A Novel Surgical Technique As a Foundation for In Vivo Partial Liver Engineering in Rat

10.3791/57991 ◽  
2018 ◽  
Author(s):  
An Wang ◽  
Isabel Jank ◽  
Weiwei Wei ◽  
Claudia Schindler ◽  
Uta Dahmen
Keyword(s):  
Surgical Technique ◽  
Liver Engineering

In-vivo organ engineering: Perfusion of hepatocytes in a single liver lobe scaffold of living rats

2016 ◽  
Vol 80 ◽  
pp. 124-131 ◽  
Author(s):  
Jun Pan ◽  
Sheng Yan ◽  
Jun-jie Gao ◽  
Ying-ying Wang ◽  
Zhong-jie Lu ◽  
...  
Keyword(s):  
Liver Lobe ◽  
Organ Engineering

Efficacy of oritavancin alone and in combination against vancomycin-susceptible and -resistant enterococci in an in-vivo Galleria mellonella survival model

2019 ◽  
Vol 54 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Kevin A. Meyer ◽  
Matthew F. Deraedt ◽  
Amanda T. Harrington ◽  
Larry H. Danziger ◽  
Eric Wenzler
Keyword(s):  
Galleria Mellonella ◽  
Survival Model

Fine Structural Changes in the Microvasculature of the Mouse Pinna: Aging and Radiation Injury

1974 ◽  
Vol 32 ◽  
pp. 54-55
Author(s):  
S. Phyllis Steamer ◽  
Rosemarie L. Devine
Keyword(s):  
Structural Changes ◽  
Radiation Treatment ◽  
Arterial Stenosis ◽  
Ultrastructural Changes ◽  
Vascular Effects ◽  
Microvascular Changes ◽  
Surrounding Connective Tissue ◽  
Fission Neutrons ◽  
Total Body

The importance of radiation damage to the skin and its vasculature was recognized by the early radiologists. In more recent studies, vascular effects were shown to involve the endothelium as well as the surrounding connective tissue. Microvascular changes in the mouse pinna were studied in vivo and recorded photographically over a period of 12-18 months. Radiation treatment at 110 days of age was total body exposure to either 240 rad fission neutrons or 855 rad 60Co gamma rays. After in vivo observations in control and irradiated mice, animals were sacrificed for examination of changes in vascular fine structure. Vessels were selected from regions of specific interest that had been identified on photomicrographs. Prominent ultrastructural changes can be attributed to aging as well as to radiation treatment. Of principal concern were determinations of ultrastructural changes associated with venous dilatations, segmental arterial stenosis and tortuosities of both veins and arteries, effects that had been identified on the basis of light microscopic observations. Tortuosities and irregularly dilated vein segments were related to both aging and radiation changes but arterial stenosis was observed only in irradiated animals.

Induction and Differentiation of Dental Epithelium in Vivo and in Vitro

1982 ◽  
Vol 40 ◽  
pp. 142-145
Author(s):  
E. J. Kollar
Keyword(s):  
Connective Tissue ◽  
Oral Mucosa ◽  
Basal Lamina ◽  
Functional Derivatives ◽  
Specific Source ◽  
Dental Epithelium ◽  
Connective Tissue Stroma

The differentiation and maintenance of many specialized epithelial structures are dependent on the underlying connective tissue stroma and on an intact basal lamina. These requirements are especially stringent in the development and maintenance of the skin and oral mucosa. The keratinization patterns of thin or thick cornified layers as well as the appearance of specialized functional derivatives such as hair and teeth can be correlated with the specific source of stroma which supports these differentiated expressions.

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