Pharmacokinetics and effects on clinical and physiological parameters following a single bolus dose of propofol in common marmosets ( Callithrix jacchus )

2020 ◽  
Author(s):  
Kanako Muta ◽  
Takako Miyabe‐Nishiwaki ◽  
Kenichi Masui ◽  
Isao Yajima ◽  
Tomoya Iizuka ◽  
...  
Keyword(s):  
Bolus Dose ◽  
Callithrix Jacchus ◽  
Physiological Parameters ◽  
Common Marmosets ◽  
Single Bolus ◽  
Single Bolus Dose

scholarly journals Comprehensive assessment of the pharmacokinetic properties of a single bolus dose of colecalciferol in terms of efficacy and safety

2019 ◽  
Vol 22 (1) ◽  
pp. 4-9
Author(s):  
Liudmila A. Suplotova ◽  
Valeria A. Avdeeva ◽  
Ekaterina A. Pigarova ◽  
Liudmila Y. Rozhinskaya
Keyword(s):  
Vitamin D ◽  
Clinical Practice ◽  
Adverse Events ◽  
Vitamin D Deficiency ◽  
Calcium Metabolism ◽  
Bolus Dose ◽  
Efficacy And Safety ◽  
Single Bolus ◽  
Pharmacokinetic Properties ◽  
Single Bolus Dose

Background: The lack of a unified approach to the treatment of deficiency and vitamin D deficiency stimulated a detailed study of the dynamics of indicators of phosphorus-calcium metabolism, parathyroid hormone, 25(OH)D (calcidiol). Aim: To evaluate the pharmacokinetic properties of colecalciferol at a dosage of 150 000 IU, from the standpoint of its efficacy and safety in clinical practice. Materials and methods: Observational, single-center, prospective, selective, uncontrolled study of a comprehensive assessment of the pharmacokinetic properties of a single saturating dose of 150 000 IU of colecalciferol. To assess the pharmacokinetic properties of colecalciferol at a dosage of 150 000 IU, we set efficacy and safety criteria. The criterion for the effectiveness of treatment was to achieve an adequate level of vitamin D (more than 30 ng / ml at the initial insufficient level and more than 20 ng / ml for patients with vitamin D deficiency). The safety criteria for the correction of vitamin D deficiency or deficiency were the absence of patient complaints, adverse events and / or serious adverse events, as well as the preservation of the main laboratory parameters of phosphorus-calcium metabolism within the reference values. Results: When studying the efficacy of a dose of 150 000 IU in patients with vitamin D deficiency and insufficiency, it was found that the level of calcidiol was significantly higher in the group after treatment with colecalciferol compared with the group before treatment (p 0.05). The peak of the maximum value for patients with deficiency was established on the 14 day from the moment of administration of colecalciferol and was 37.1 6.28 ng / ml, and for patients with initial vitamin D deficiency 40.1 3.71 ng / ml. In the study of the safety of colecalciferol in a bolus dose of 150 000 IU, there were no statistically significant differences in the laboratory parameters of calcium-phosphorus metabolism, both in the group before treatment and after correction of deficiency and vitamin D insufficiency in both groups. Conclusion: Colecalciferol in the form of a single bolus dose of 150 000 IU demonstrated its efficacy and safety in real clinical practice.

scholarly journals Influence of Reversal with Sugammadex or Neostigmine on Post-Operative Quality of Recovery Following a Single Bolus Dose of Rocuronium: A Prospective, Randomised, Double-Blinded, Controlled Study

2018 ◽  
Author(s):  
Sun-Joon Bai ◽  
Ki-Young Lee ◽  
Sung Soo Kim ◽  
Jung Hwa Hong ◽  
Hoon Jae Nam ◽  
...  
Keyword(s):  
General Anaesthesia ◽  
Bolus Dose ◽  
Controlled Study ◽  
Single Bolus ◽  
Quality Of Recovery ◽  
Single Bolus Dose ◽  
Pars Plana ◽  
Double Blinded ◽  
Operative Quality

There is a lack of data comparing sugammadex with anticholinesterase for the quality of anaesthesia recovery, especially following a single bolus dose of rocuronium. Thus, we evaluated the influence of reversal with sugammadex or neostigmine on post-operative quality of recovery by using the Post-operative Quality Recovery Scale (PQRS). A total of 86 patients undergoing trans-pars plana vitrectomy (TPPV) under general anaesthesia were intubated following a single bolus dose of rocuronium (0.6 mg/kg). At the end of surgery, patients were received either neostigmine or sugammadex. The quality of recovery was assessed using the PQRS at 15 minutes and 40 minutes after surgery, and on post-operative day 1. The recovery rate in the physiological domain was higher in the sugammadex group at 15 minutes after surgery (P = 0.02). Though there were no significant differences in the overall cognitive recovery domain, patients in the sugammadex group could recall more numbers in reverse order. However, there were no significant differences between the groups in the other domains of the PQRS. The use of sugammadex may increase the quality of the post-operative physiological recovery at early post-operative periods compared with neostigmine use following a single bolus dose of rocuronium in patients undergoing TPPV with general anaesthesia.

Delayed Wound Healing in Hemophilia B Mice.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3199-3199
Author(s):  
Maureane Hoffman ◽  
Angie Lenkowski ◽  
Jacqueline Brock ◽  
Ulla Hedner ◽  
Dougald M. Monroe
Keyword(s):  
Wound Healing ◽  
Bolus Dose ◽  
Healing Time ◽  
Factor Ix ◽  
Hemophilia B ◽  
Single Bolus ◽  
Starting Point ◽  
Single Bolus Dose ◽  
B Mice ◽  
Wound Healing Time

Abstract These studies use our previously reported wound healing model to establish the mechanisms behind the impaired wound healing we observed in hemophilia B animals. We hypothisized that thrombin mediated signals generated in response to the initial wound would be absent or reduced in hemophilia B mice, leading to an impaired course of wound healing and poor angiogenesis. All work was done in accord with the US Amended Animal Welfare Act and was monitored by the Institutional Animal Care and Use Committee of UNC. Three mm circular dermal wounds were made in normal and hemophilia B mice. All wounds were treated with an antibiotic gel at the time the wound was made. The mice were monitored for bleeding both at the time the wound was made and for delayed bleeding. Hemophilia B mice with excessive bleeding were treated. The wounds were monitored for regrowth of the epithelial layer. The size of the area not covered by epithelial tissue was measured and expressed as square millimeters (wound size). We have previously reported that there is a significant difference in the time to wound healing between untreated hemophilic (10 days) and normal animals (7 days). At the end of the time course, wound areas were excised and the skin was formalin fixed, paraffin embedded, and sectioned. Essentially all hemophilia but no normal animals showed unresolved subcutaneous hematoma. During the wound healing process, macrophage infiltration into the granulation tissue was significantly delayed. Unexpectedly, hemophilia B mice relative to wild type mice showed twice as many blood vessels in the healing wound. This difference persisted out to two weeks after the wound was made and well after reepithelialization. Pretreatment (30 minutes prior to wounding) of hemophilia B mice with a single bolus dose of human factor IX sufficient to give 1 U/mL corrected the wound healing time. Pretreated hemophilia B mice did not have obvious subcutaneous hematomoas. The observation that a single bolus dose of factor IX prior to wounding a hemophilia B animal normalized the wound healing time provides a starting point for determining how different doses or different administration times effect wound healing. It also provides a starting point from which to compare the effects of bypassing therapy on wound healing.

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