Effect of atorvastatin on oxidative stress and inflammation markers in myxomatous mitral valve disease in dogs: A comparison of subclinical and clinical stages

2019 ◽  
Vol 42 (3) ◽  
pp. 258-267
Author(s):  
Patchaya Thassakorn ◽  
Papras Patchanee ◽  
Wanpitak Pongkan ◽  
Nipon Chattipakorn ◽  
Chavalit Boonyapakorn
Keyword(s):  
Oxidative Stress ◽  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Valve Disease ◽  
Inflammation Markers ◽  
Clinical Stages

scholarly journals New pathway in rheumatic mitral valve disease: cytochrome P450 and glutathione S transferase isozyme expression

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Erdal Simsek ◽  
Gulcin Simsek ◽  
Mehmet Fazıl Tolga Soyal ◽  
Pinar Kaygin ◽  
Ali Cemal Duzgun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cytochrome P450 ◽  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Mitral Valve Insufficiency ◽  
Valve Disease ◽  
Control Group ◽  
Study Group ◽  
Glutathione S Transferase ◽  
Valve Insufficiency

AbstractObjectiveCytochrome P450 (CYP)1A1, glutathione S-transferase pi (GSTP1) and omega (GSTO1) isozymes were evaluated and compared in patients with the diagnosis of rheumatic mitral valve disease and ischemic mitral valve insufficiency to find out the relationship of the oxidative stress with rheumatic mitral valve disease.Materials and methodsThe control group consisted of patients operated on due to ischemic mitral valve insufficiency (group I, n:14) while study group consisted of the patients operated on with the diagnosis of rheumatic mitral valve disease (group II, n:29). Mitral valve materials were stained with hematoxylin and eosin. CYP1A1, GSTP1, and GSTO1 immunohistochemical markers were studied.Results20.7% of GSTP1 isozyme protein expression was seen in the study group; however, no expression was detected in the control group. This finding was statistically significant in terms of GSTP1 isozyme. No statistically significant differences in the level of GSTO1 and CYP1A1 protein expression between the study and control groups were observed.ConclusionIn this study, we found out that GSTP1 isozyme may be related to rheumatic mitral valve disease. A strategy that would help prevent oxidative stress in patients with rheumatic mitral valve disease can be a so valuable means to affect disease progression.

Early and long-term outcomes of surgery for acute decompensated mitral valve disease

2013 ◽  
Vol 61 (S 01) ◽  
Author(s):  
S Leontyev ◽  
P Davierwala ◽  
M Schneevoigt ◽  
S Lehmann ◽  
J Seeburger ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Mitral Valve Disease ◽  
Valve Disease ◽  
Long Term Outcomes
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