In vitro and in vivo evaluation of an in situ forming gel system for sustained delivery of Florfenicol

2014 ◽  
Vol 38 (3) ◽  
pp. 271-277 ◽  
Author(s):  
Z.-G. Yu ◽  
Z.-X. Geng ◽  
T.-F. Liu ◽  
F. Jiang
Keyword(s):  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
In Situ Forming ◽  
In Situ Forming Gel ◽  
Gel System

Comparison of in-situ forming composite using PLGA-PEG-PLGA with in-situ forming implant using PLGA: In-vitro, ex-vivo, and in-vivo evaluation of naltrexone release

2019 ◽  
Vol 50 ◽  
pp. 188-200 ◽  
Author(s):  
Hossein Kamali ◽  
Elham Khodaverdi ◽  
Farzin Hadizadeh ◽  
Seyed Ahmad Mohajeri ◽  
Ali Nazari ◽  
...  
Keyword(s):  
Ex Vivo ◽  
In Vivo Evaluation ◽  
In Situ Forming

Design of novel injectable in-situ forming scaffolds for non-surgical treatment of periapical lesions: In-vitro and in-vivo evaluation

2017 ◽  
Vol 521 (1-2) ◽  
pp. 306-317 ◽  
Author(s):  
Rehab N. Shamma ◽  
Nermeen A. Elkasabgy ◽  
Azza A. Mahmoud ◽  
Shaimaa I. Gawdat ◽  
Mohamed M. Kataia ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
In Vivo Evaluation ◽  
Periapical Lesions ◽  
In Situ Forming ◽  
Non Surgical Treatment

In vitro and in vivo release of albumin from an electrostatically crosslinked in situ-forming gel

2010 ◽  
Vol 20 (16) ◽  
pp. 3265 ◽  
Author(s):  
Ju Young Lee ◽  
Yun Mi Kang ◽  
E Sle Kim ◽  
Mi Lan Kang ◽  
Bong Lee ◽  
...  
Keyword(s):  
In Situ Forming ◽  
In Vivo Release ◽  
In Situ Forming Gel

Study of an injectable in situ forming gel for sustained-release of Ivermectin in vitro and in vivo

2016 ◽  
Vol 85 ◽  
pp. 271-276 ◽  
Author(s):  
Zhixia Geng ◽  
Xiaoqing Luo ◽  
Zhenrui Zhang ◽  
Huimin Li ◽  
Jing Tian ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Situ Forming ◽  
In Situ Forming Gel

Synthesis, Characterization and in vivo Evaluation of PEGylated PPI Dendrimer for Safe and Prolonged Delivery of Insulin

2019 ◽  
Vol 9 (3) ◽  
pp. 248-263 ◽  
Author(s):  
Ashish K. Parashar ◽  
Preeti Patel ◽  
Arun K. Gupta ◽  
Neetesh K. Jain ◽  
Balak Das Kurmi
Keyword(s):  
Blood Glucose ◽  
Drug Release ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Albino Rats ◽  
Sustained Delivery ◽  
In Vivo Evaluation ◽  
Hemolytic Toxicity

Background: The present study was aimed at developing and exploring the use of PEGylated Poly (propyleneimine) dendrimers for the delivery of an anti-diabetic drug, insulin. Methods: For this study, 4.0G PPI dendrimer was synthesized by successive Michael addition and exhaustive amidation reactions, using ethylenediamine as the core and acrylonitrile as the propagating agent. Two different activated PEG moieties were employed for PEGylation of PPI dendrimers. Various physicochemical and physiological parameters UV, IR, NMR, TEM, DSC, drug entrapment, drug release, hemolytic toxicity and blood glucose level studies of both PEGylated and non- PEGylated dendritic systems were determined and compared. Results: PEGylation of PPI dendrimers caused increased solubilization of insulin in the dendritic framework as well as in PEG layers, reduced drug release and hemolytic toxicity as well as increased therapeutic efficacy with reduced side effects of insulin. These systems were found to be suitable for sustained delivery of insulin by in vitro and blood glucose-level studies in albino rats, without producing any significant hematological disturbances. Conclusion: Thus, surface modification of PPI dendrimers with PEG molecules has been found to be a suitable approach to utilize it as a safe and effective nano-carrier for drug delivery.

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming
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