In vitro and in vivo release of albumin from an electrostatically crosslinked in situ-forming gel

2010 ◽  
Vol 20 (16) ◽  
pp. 3265 ◽  
Author(s):  
Ju Young Lee ◽  
Yun Mi Kang ◽  
E Sle Kim ◽  
Mi Lan Kang ◽  
Bong Lee ◽  
...  
Keyword(s):  
In Situ Forming ◽  
In Vivo Release ◽  
In Situ Forming Gel

In-vitro, ex-vivo, and in-vivo release evaluation of in situ forming buprenorphine implants using mixture of PLGA copolymers and additives

2018 ◽  
Vol 68 (16) ◽  
pp. 965-977 ◽  
Author(s):  
Hossein Kamali ◽  
Elham Khodaverdi ◽  
Farzin Hadizadeh ◽  
Seyed Ahmad Mohajeri ◽  
Younes Kamali ◽  
...  
Keyword(s):  
Ex Vivo ◽  
In Situ Forming ◽  
In Vivo Release

Study of an injectable in situ forming gel for sustained-release of Ivermectin in vitro and in vivo

2016 ◽  
Vol 85 ◽  
pp. 271-276 ◽  
Author(s):  
Zhixia Geng ◽  
Xiaoqing Luo ◽  
Zhenrui Zhang ◽  
Huimin Li ◽  
Jing Tian ◽  
...  
Keyword(s):  
Sustained Release ◽  
In Situ Forming ◽  
In Situ Forming Gel

In Vitro and In Vivo Drug Release from a Novel In Situ Forming Drug Delivery System

2007 ◽  
Vol 25 (6) ◽  
pp. 1347-1354 ◽  
Author(s):  
Heiko Kranz ◽  
Erol Yilmaz ◽  
Gayle A. Brazeau ◽  
Roland Bodmeier
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Situ Forming

scholarly journals Tripling the Bioavailability of Rosuvastatin Calcium Through Development and Optimization of an In-Situ Forming Nanovesicular System

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 275 ◽  
Author(s):  
Ibrahim Elsayed ◽  
Rania Moataz El-Dahmy ◽  
Ahmed Hassen Elshafeey ◽  
Nabaweya Abdelaziz Abd El Gawad ◽  
Omaima Naim El Gazayerly
Keyword(s):  
Dissolution Rate ◽  
Oral Bioavailability ◽  
Entrapment Efficiency ◽  
In Situ Forming ◽  
Market Product ◽  
Simple Step ◽  
Rosuvastatin Calcium

In situ forming nanovesicular systems (IFNs) were prepared and optimized to improve Rosuvastatin calcium (RC) oral bioavailability through increasing its solubility and dissolution rate. The IFN was composed of Tween® 80 (T80), cetyl alcohol (CA), in addition to mannitol or Aerosil 200. A single simple step was adopted for preparation, then the prepared formulations were investigated by analyzing their particle size (PS), polydispersity index (PDI), Zeta potential (ZP), entrapment efficiency (EE), and flowability properties. D-optimal design was applied to choose the optimized formulations. The maximum desirability values were 0.754 and 0.478 for the optimized formulations containing 0.05 g CA, 0.18 g T80, and 0.5 g mannitol (OFM) or Aerosil (OFA), respectively. In vitro drug release from the optimized formulations showed a significantly faster dissolution rate when compared to the market product. In vivo performance of the optimized formulations in rabbits was investigated after filling them into enteric-coated capsules. Ultimately, OFA formulation achieved a 3 times increase in RC oral bioavailability in comparison with the market product, supporting the hypothesis of considering IFNs as promising nanocarriers able to boost the bioavailability of BCS class II drugs.

In Vitro and in Vivo Release of Albumin Using a Biodegradable MPEG-PCL Diblock Copolymer as an in Situ Gel-Forming Carrier

2007 ◽  
Vol 8 (4) ◽  
pp. 1093-1100 ◽  
Author(s):  
Hoon Hyun ◽  
Yu Han Kim ◽  
In Bum Song ◽  
Jung Won Lee ◽  
Moon Suk Kim ◽  
...  
Keyword(s):  
Diblock Copolymer ◽  
In Situ Gel ◽  
In Vivo Release
Sign in / Sign up

Export Citation Format

Share Document