Next‐generation sequencing of the intrahepatic antibody repertoire delineates a unique B‐cell response in HBV‐associated acute liver failure

2020 ◽  
Vol 27 (8) ◽  
pp. 847-851
Author(s):  
Zhaochun Chen ◽  
Chen‐Hsiang Shen ◽  
Ronald E. Engle ◽  
Fausto Zamboni ◽  
Peter D. Kwong ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
B Cell ◽  
Cell Response ◽  
Antibody Repertoire ◽  
Next Generation ◽  
Generation Sequencing ◽  
B Cell Response

scholarly journals Viral Surveillance in Serum Samples From Patients With Acute Liver Failure By Metagenomic Next-Generation Sequencing

2017 ◽  
Vol 65 (9) ◽  
pp. 1477-1485 ◽  
Author(s):  
Sneha Somasekar ◽  
Deanna Lee ◽  
Jody Rule ◽  
Samia N Naccache ◽  
Mars Stone ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Next Generation ◽  
Serum Samples ◽  
Viral Surveillance ◽  
Generation Sequencing

scholarly journals Acute Liver Failure Due to Echovirus 9 Associated With Persistent B-Cell Depletion From Rituximab

2017 ◽  
Vol 4 (3) ◽  
Author(s):  
Kristina L Bajema ◽  
Paul D Simonson ◽  
Alex L Greninger ◽  
Basak Çoruh ◽  
Paul S Pottinger ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Next Generation Sequencing ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
B Cell ◽  
Early Recognition ◽  
Etiologic Agent ◽  
Cell Depletion ◽  
B Cell Depletion ◽  
Generation Sequencing

Abstract We describe a case of fatal acute liver failure due to echovirus 9 in the setting of persistent B-cell depletion and hypogammaglobulinemia 3 years after rituximab therapy. Metagenomic next-generation sequencing further specified the etiologic agent. Early recognition may provide an opportunity for interventions including intravenous immunoglobulin and liver transplantation.

Comprehensive detection of viruses in pediatric patients with acute liver failure using next-generation sequencing

2017 ◽  
Vol 96 ◽  
pp. 67-72 ◽  
Author(s):  
Takako Suzuki ◽  
Jun-ichi Kawada ◽  
Yusuke Okuno ◽  
Satoshi Hayano ◽  
Kazuhiro Horiba ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Pediatric Patients ◽  
Next Generation ◽  
Generation Sequencing

scholarly journals Next-Generation Sequencing in Adult B Cell Acute Lymphoblastic Leukemia Patients

2017 ◽  
Vol 23 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Olga Sala Torra ◽  
Megan Othus ◽  
David W. Williamson ◽  
Brent Wood ◽  
Ilan Kirsch ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Acute Lymphoblastic Leukemia ◽  
B Cell ◽  
Lymphoblastic Leukemia ◽  
Next Generation ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Generation Sequencing
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