Persistent gamma delta T‐cell dysfunction in HCV/HIV co‐infection despite direct‐acting antiviral therapy‐induced cure

2020 ◽  
Vol 27 (7) ◽  
pp. 754-756 ◽  
Author(s):  
Eleonora Cimini ◽  
Alessandra Sacchi ◽  
Germana Grassi ◽  
Rita Casetti ◽  
Stefania Notari ◽  
...  
Keyword(s):  
T Cell ◽  
Antiviral Therapy ◽  
Gamma Delta ◽  
Direct Acting Antiviral ◽  
Cell Dysfunction ◽  
T Cell Dysfunction ◽  
Direct Acting ◽  
Gamma Delta T Cell

scholarly journals Microbial translocation and T cell activation are modified by direct-acting antiviral therapy in HCV-infected patients

2018 ◽  
Vol 48 (10) ◽  
pp. 1146-1155 ◽  
Author(s):  
Barbara Lattanzi ◽  
Silvia Baroncelli ◽  
Adriano De Santis ◽  
Clementina Maria Galluzzo ◽  
Gianluca Mennini ◽  
...  
Keyword(s):  
T Cell ◽  
Antiviral Therapy ◽  
T Cell Activation ◽  
Cell Activation ◽  
Microbial Translocation ◽  
Direct Acting Antiviral ◽  
Direct Acting

FRI-147-Gradual restoration of HCV-specific CD8+ T cell frequency but persistence of altered phenotype in cirrhotic HCV-infected patients after successful direct-acting antiviral therapy

2019 ◽  
Vol 70 (1) ◽  
pp. e453
Author(s):  
Elena Perpiñan ◽  
Sofía Pérez-del-Pulgar ◽  
Maria Carlota Londoño ◽  
Patricia González ◽  
Zoe Mariño ◽  
...  
Keyword(s):  
T Cell ◽  
Antiviral Therapy ◽  
Cd8 T Cell ◽  
Cell Frequency ◽  
Direct Acting Antiviral ◽  
Direct Acting

The resistance of HIV‐infected chimpanzees to progression to AIDS correlates with absence of HIV‐related T‐cell dysfunction

1993 ◽  
Vol 22 (2-3) ◽  
pp. 194-200 ◽  
Author(s):  
Jonathan Heeney ◽  
Richard Jonker ◽  
Wim Koornstra ◽  
Rob Dubbes ◽  
Henk Niphuis ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Dysfunction ◽  
T Cell Dysfunction

scholarly journals Tim-3 adaptor protein Bat3 is a molecular checkpoint of T cell terminal differentiation and exhaustion

2021 ◽  
Vol 7 (18) ◽  
pp. eabd2710
Author(s):  
Chen Zhu ◽  
Karen O. Dixon ◽  
Kathleen Newcomer ◽  
Guangxiang Gu ◽  
Sheng Xiao ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Adaptor Protein ◽  
Transcriptional Analysis ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
Cell Dysfunction ◽  
Autoreactive T Cell ◽  
Autoimmune Conditions ◽  
T Cell Dysfunction

T cell exhaustion has been associated with poor prognosis in persistent viral infection and cancer. Conversely, in the context of autoimmunity, T cell exhaustion has been favorably correlated with long-term clinical outcome. Understanding the development of exhaustion in autoimmune settings may provide underlying principles that can be exploited to quell autoreactive T cells. Here, we demonstrate that the adaptor molecule Bat3 acts as a molecular checkpoint of T cell exhaustion, with deficiency of Bat3 promoting a profound exhaustion phenotype, suppressing autoreactive T cell–mediated neuroinflammation. Mechanistically, Bat3 acts as a critical mTORC2 inhibitor to suppress Akt function. As a result, Bat3 deficiency leads to increased Akt activity and FoxO1 phosphorylation, indirectly promoting Prdm1 expression. Transcriptional analysis of Bat3−/− T cells revealed up-regulation of dysfunction-associated genes, concomitant with down-regulation of genes associated with T cell effector function, suggesting that absence of Bat3 can trigger T cell dysfunction even under highly proinflammatory autoimmune conditions.

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