Risk of hepatitis B virus reactivation in hepatitis B virus + hepatitis C virus-co-infected patients with compensated liver cirrhosis treated with ombitasvir, paritaprevir/r + dasabuvir + ribavirin

2018 ◽  
Vol 25 (7) ◽  
pp. 834-841 ◽  
Author(s):  
C. M. Preda ◽  
C. P. Popescu ◽  
C. Baicus ◽  
I. Constantinescu ◽  
A. Oproiu ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Reactivation ◽  
Virus Hepatitis ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

Proportion of Nonalcoholic Steatohepatitis in Patients with Chronic Liver Disease

2021 ◽  
Vol 15 (6) ◽  
pp. 1272-1274
Author(s):  
H.A. Abro ◽  
B. A. Shaikh ◽  
A. H. Mugheri ◽  
I. A. Ansari ◽  
Z. A. Shaikh ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Liver Disease ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Nonalcoholic Steatohepatitis ◽  
Smoking Status ◽  
Virus Hepatitis ◽  
B Virus

Aim: To determine the frequency of nonalcoholic steatohepatitis in patients with liver cirrhosis. Study Design: Retrospective/observational Place and Duration of Study: Department of Medicine, Chandka Medical College Hospital, Larkana from 1st July 2020 to 31st March 2021. Methodology: One hundred and twenty patients of both genders presented with liver cirrhosis were enrolled in this study. Patient’s detailed demographics including age, sex, body mass index, smoking status, alcohol consumption and family history of liver disease were recorded after taking written informed consent. Laboratory examination was done to examine the proportion of hepatitis B virus, hepatitis C virus and nonalcoholic steatohepatitis. Results: There were 68 (56.67%) males and 52 (43.33%) were females with mean age 45.74±10.54 years. Among all the patients hepatitis C virus was found in 62 (51.67%) patients, 15 (12.5%) had hepatitis B virus, 17 (14.17%) had hepatitis B virus + hepatitis C virus and nonalcoholic steatohepatitis was found in 26 (21.67%) patients. Conclusion: Nonalcoholic steatohepatitis was the major cause of liver cirrhosis in Pakistani population. The proportion of NASH in liver cirrhosis patients was 21.67%. Keywords: Nonalcoholic steatohepatitis (NASH), Liver Cirrhosis, Hepatitis B virus, Hepatitis C virus

scholarly journals Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Luca Foroghi Biland ◽  
Ludovica Ferrari ◽  
Vincenzo Malagnino ◽  
Elisabetta Teti ◽  
Carlotta Cerva ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Virus Reactivation ◽  
Virus Surface ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

Abstract Background Although several cases of hepatitis B virus reactivation have been described in patients with a history of hepatitis B virus infection while undergoing treatment for hepatitis C virus infection with direct acting antivirals, the question of whether hepatitis B virus surface antigen immune-escape mutations might play a role has not been addressed so far. Case presentation We report a case of hepatitis B virus reactivation in a Caucasian patient infected with hepatitis C virus during treatment with sofosbuvir and velpatasvir. A 50-year-old man with a genotype 1a hepatitis C virus infection was considered for therapy. His serological profile was hepatitis B virus surface antigen-negative, hepatitis B virus core antibody-positive, hepatitis B virus surface antibody-negative, and anti-hepatitis D virus-positive. The detection of hepatitis B virus deoxyribonucleic acid (DNA) indicated active viral replication during the direct acting antiviral treatment that spontaneously returned to undetectable levels after treatment completion. Starting from week 12 after the end of treatment, hepatitis B virus surface antibody titers and hepatitis B virus e antibody developed. Sequencing analysis revealed the hepatitis B virus genotype D3 and the presence of two relevant immune-escape mutations (P120S and T126I) in the major hydrophilic region by analyzing the S region. Conclusions We speculate that the presence of the hepatitis B virus surface antigen mutations, endowed with the enhanced capability to elude the immune response, could play a role in hepatitis B virus reactivation. This observation confirms that occult hepatitis B infection should also be carefully monitored, through surveillance of the hepatitis B virus viral load before and during direct acting antiviral treatment of hepatitis C virus.

scholarly journals Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir: Figure 1.

2015 ◽  
Vol 61 (8) ◽  
pp. 1304-1306 ◽  
Author(s):  
Jeffrey M. Collins ◽  
Kara Loren Raphael ◽  
Charles Terry ◽  
Emily J. Cartwright ◽  
Anjana Pillai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Successful Treatment ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

scholarly journals Hepatitis B virus reactivation after successful treatment of hepatitis C virus with sofosbuvir and ribavirin

Medicine ◽  
2020 ◽  
Vol 99 (41) ◽  
pp. e22650 ◽  
Author(s):  
Akio Miyasaka ◽  
Yuichi Yoshida ◽  
Akiko Suzuki ◽  
Tomoyuki Masuda ◽  
Hiroaki Okamoto ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Successful Treatment ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus
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