scholarly journals Interferon-Free Regimens in Hepatitis B Surface Antigen/Anti–Hepatitis C Virus Positive Patients: The Need to Control Hepatitis B Virus Replication to Avoid Hepatitis B Virus Reactivation

2017 ◽  
Vol 15 (11) ◽  
pp. 1800-1802 ◽  
Author(s):  
Margherita Macera ◽  
Maria Stanzione ◽  
Vincenzo Messina ◽  
Giuseppe D'Adamo ◽  
Vincenzo Sangiovanni ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Virus Replication ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

scholarly journals Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Luca Foroghi Biland ◽  
Ludovica Ferrari ◽  
Vincenzo Malagnino ◽  
Elisabetta Teti ◽  
Carlotta Cerva ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Virus Reactivation ◽  
Virus Surface ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

Abstract Background Although several cases of hepatitis B virus reactivation have been described in patients with a history of hepatitis B virus infection while undergoing treatment for hepatitis C virus infection with direct acting antivirals, the question of whether hepatitis B virus surface antigen immune-escape mutations might play a role has not been addressed so far. Case presentation We report a case of hepatitis B virus reactivation in a Caucasian patient infected with hepatitis C virus during treatment with sofosbuvir and velpatasvir. A 50-year-old man with a genotype 1a hepatitis C virus infection was considered for therapy. His serological profile was hepatitis B virus surface antigen-negative, hepatitis B virus core antibody-positive, hepatitis B virus surface antibody-negative, and anti-hepatitis D virus-positive. The detection of hepatitis B virus deoxyribonucleic acid (DNA) indicated active viral replication during the direct acting antiviral treatment that spontaneously returned to undetectable levels after treatment completion. Starting from week 12 after the end of treatment, hepatitis B virus surface antibody titers and hepatitis B virus e antibody developed. Sequencing analysis revealed the hepatitis B virus genotype D3 and the presence of two relevant immune-escape mutations (P120S and T126I) in the major hydrophilic region by analyzing the S region. Conclusions We speculate that the presence of the hepatitis B virus surface antigen mutations, endowed with the enhanced capability to elude the immune response, could play a role in hepatitis B virus reactivation. This observation confirms that occult hepatitis B infection should also be carefully monitored, through surveillance of the hepatitis B virus viral load before and during direct acting antiviral treatment of hepatitis C virus.

scholarly journals Clearance of hepatitis B surface antigen and hepatitis C virus antibody in hepatitis B virus carriers.

Kanzo ◽  
1992 ◽  
Vol 33 (7) ◽  
pp. 511-516
Author(s):  
Kazuo NOTSUMATA ◽  
Tadao YAMAZAKI ◽  
Masayoshi ITO ◽  
Yukihiro SAKURAI ◽  
Satio TAKASU ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Virus Antibody ◽  
B Virus ◽  
Hepatitis C Virus Antibody

scholarly journals Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression

Hepatology ◽  
2015 ◽  
Vol 61 (3) ◽  
pp. 823-833 ◽  
Author(s):  
Romina Salpini ◽  
Luna Colagrossi ◽  
Maria Concetta Bellocchi ◽  
Matteo Surdo ◽  
Christina Becker ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Immune Escape ◽  
Hepatitis B Surface Antigen ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
Genetic Elements ◽  
B Virus

Hepatitis B virus reactivation during combined therapy with deferiprone and desferioxamine in a hepatitis B surface antigen thalassemic carrier

2008 ◽  
Vol 89 (2) ◽  
pp. 135-138 ◽  
Author(s):  
Paolo Ricchi ◽  
Patrizia Cinque ◽  
Alfonso Lanza Galeota ◽  
Tiziana Di Matola ◽  
Massimiliano Ammirabile ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Combined Therapy ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus

scholarly journals Hepatitis B Virus Reactivation During Successful Treatment of Hepatitis C Virus With Sofosbuvir and Simeprevir: Figure 1.

2015 ◽  
Vol 61 (8) ◽  
pp. 1304-1306 ◽  
Author(s):  
Jeffrey M. Collins ◽  
Kara Loren Raphael ◽  
Charles Terry ◽  
Emily J. Cartwright ◽  
Anjana Pillai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Successful Treatment ◽  
Virus Reactivation ◽  
Hepatitis B Virus Reactivation ◽  
B Virus
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