scholarly journals Spatial distribution of sand fly species (Psychodidae: Phlebtominae), ecological niche, and climatic regionalization in zoonotic foci of cutaneous leishmaniasis, southwest of Iran

2016 ◽  
Vol 41 (1) ◽  
pp. 103-109 ◽  
Author(s):  
Sahar Ebrahimi ◽  
Ali Bordbar ◽  
Ahmad R. Esmaeili Rastaghi ◽  
Parviz Parvizi
Keyword(s):  
Spatial Distribution ◽  
Cutaneous Leishmaniasis ◽  
Ecological Niche ◽  
Sand Fly ◽  
Climatic Regionalization ◽  
Southwest Of Iran

scholarly journals Spatial Distribution of Sand Fly Vectors and Eco-Epidemiology of Cutaneous Leishmaniasis Transmission in Colombia

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139391 ◽  
Author(s):  
Cristina Ferro ◽  
Marla López ◽  
Patricia Fuya ◽  
Ligia Lugo ◽  
Juan Manuel Cordovez ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Sand Fly Vectors

scholarly journals Spatial distribution and epidemiological features of cutaneous leishmaniasis in southwest of Iran

2017 ◽  
Vol 53 (1) ◽  
pp. 93-98 ◽  
Author(s):  
S. Khademvatan ◽  
S. Salmanzadeh ◽  
M. Foroutan-Rad ◽  
S. Bigdeli ◽  
F. Hedayati-Rad ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Cutaneous Leishmaniasis ◽  
Epidemiological Features ◽  
Southwest Of Iran

scholarly journals A sand fly salivary protein vaccine shows efficacy against vector-transmitted cutaneous leishmaniasis in nonhuman primates

2015 ◽  
Vol 7 (290) ◽  
pp. 290ra90-290ra90 ◽  
Author(s):  
Fabiano Oliveira ◽  
Edgar Rowton ◽  
Hamide Aslan ◽  
Regis Gomes ◽  
Philip A. Castrovinci ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Nonhuman Primates ◽  
Mononuclear Cells ◽  
Rhesus Macaques ◽  
Parasite Burden ◽  
Salivary Protein ◽  
Sand Fly ◽  
Protein Vaccine ◽  
Peripheral Blood Mononuclear ◽  
Phlebotomus Duboscqi

Currently, there are no commercially available human vaccines against leishmaniasis. In rodents, cellular immunity to salivary proteins of sand fly vectors is associated to protection against leishmaniasis, making them worthy targets for further exploration as vaccines. We demonstrate that nonhuman primates (NHP) exposed to Phlebotomus duboscqi uninfected sand fly bites or immunized with salivary protein PdSP15 are protected against cutaneous leishmaniasis initiated by infected bites. Uninfected sand fly–exposed and 7 of 10 PdSP15-immunized rhesus macaques displayed a significant reduction in disease and parasite burden compared to controls. Protection correlated to the early appearance of Leishmania-specific CD4+IFN-γ+ lymphocytes, suggesting that immunity to saliva or PdSP15 augments the host immune response to the parasites while maintaining minimal pathology. Notably, the 30% unprotected PdSP15-immunized NHP developed neither immunity to PdSP15 nor an accelerated Leishmania-specific immunity. Sera and peripheral blood mononuclear cells from individuals naturally exposed to P. duboscqi bites recognized PdSP15, demonstrating its immunogenicity in humans. PdSP15 sequence and structure show no homology to mammalian proteins, further demonstrating its potential as a component of a vaccine for human leishmaniasis.

scholarly journals Intestinal helminthiasis as a relevant factor on immunological markers status of cutaneous leishmaniasis patients

2020 ◽  
Author(s):  
ALEIDA VERDUGUEZ-ORELLANA ◽  
Ernesto Rojas Cabrera ◽  
Mery Arteaga Terrazas ◽  
Fidelia Barrientos Laura ◽  
Miguel Guzman-Rivero
Keyword(s):  
Immune Response ◽  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Intestinal Helminths ◽  
Sanitation Services ◽  
Immunological Markers ◽  
Tnf Α ◽  
Before And After ◽  
The Status ◽  
Basic Sanitation

Abstract Background: The intestinal helminths and the tegumentary leishmaniasis are frequent in rain forest area of Bolivia by absence of basic sanitation services and the natural presence of sand fly, vector of Leishmania parasites. Each one of these infections triggers a specific immune response by the host, nevertheless there is scant information regarding the behaviour of immune response during simultaneous Leishmania and intestinal helminths infections. The purpose of this study was contributing to the knowledge on this matter. Results: Forty-four cutaneous leishmaniasis patients and thirty controls entered in the study. The percentage of eosinophils from peripheral blood and plasma concentration of IgE and TNF-α were increased at after antimony treatment, respect the values presented before treatment in Albendazole and Non Albendazole groups, those increases were not statically significant. A decrease between before and after antimony treatment was observed in the ratio CD4/CD8 in both groups, but only in the receiving Albendazole group it was presented differences statistically significant.Conclusions: Several changes in the status of immunological markers including the number of eosinophils were found after the antimony treatment of patients. No additional clinical, neither immunological benefit of Albendazole treatment could be documented probably because the contact of individuals with helminths is long-standing.

scholarly journals Cutaneous Leishmaniasis in dogs: is high seroprevalence indicative of a reservoir role?

Parasitology ◽  
2015 ◽  
Vol 142 (9) ◽  
pp. 1202-1214 ◽  
Author(s):  
JOSÉ E. CALZADA ◽  
AZAEL SALDAÑA ◽  
KADIR GONZÁLEZ ◽  
CHYSTRIE RIGG ◽  
VANESSA PINEDA ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Complex Disease ◽  
Basic Reproductive Number ◽  
Sand Fly ◽  
Reproductive Number ◽  
Cross Sectional ◽  
Rich Diversity ◽  
Ecosystem Level ◽  
Reservoir Hosts ◽  
Sand Fly Vectors

SUMMARYAmerican cutaneous leishmaniasis (ACL) is a complex disease with a rich diversity of animal host species. This diversity imposes a challenge, since understanding ACL transmission requires the adequate identification of reservoir hosts, those species able to be a source of additional infections. In this study we present results from an ACL cross-sectional serological survey of 51 dogs (Canis familiaris), where we used diagnostic tests that measure dog's exposure toLeishmaniaspp. parasites. We did our research in Panamá, at a village that has undergone significant ecosystem level transformations. We found an ACL seroprevalence of 47% among dogs, and their exposure was positively associated with dog age and abundance of sand fly vectors in the houses of dog owners. Using mathematical models, which were fitted to data on the proportion of positive tests as function of dog age, we estimated a basic reproductive number (R0±s.e.) of 1·22 ± 0·09 that indicates the disease is endemically established in the dogs. Nevertheless, this information by itself is insufficient to incriminate dogs as ACL reservoirs, given the inability to find parasites (or their DNA) in seropositive dogs and previously reported failures to experimentally infect vectors feeding on dogs with ACL parasites.

scholarly journals Cutaneous leishmaniasis: an epidemiological study in southwest of Iran

2019 ◽  
Vol 43 (2) ◽  
pp. 190-197 ◽  
Author(s):  
Shahrzad Soltani ◽  
Masoud Foroutan ◽  
Maryam Hezarian ◽  
Hamed Afshari ◽  
Mehdi Sagha Kahvaz
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Epidemiological Study ◽  
Southwest Of Iran

scholarly journals Genotyping the causative agents of cutaneous leishmaniasis in Ahvaz southwest of Iran

2020 ◽  
Vol 44 (2) ◽  
pp. 436-440
Author(s):  
Raziyeh Zeinvand Lorestani ◽  
Reza Arjmand ◽  
Jasem Saki ◽  
Ali Jelowdar ◽  
Shokrollah Salmanzadeh
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Causative Agents ◽  
Southwest Of Iran

scholarly journals Spatial distribution of phlebotomine sand flies in the Aydin Mountains and surroundings: the main focus of cutaneous leishmaniasis in western Turkey

2011 ◽  
Vol 36 ◽  
pp. S99-S105 ◽  
Author(s):  
Yusuf Özbel ◽  
I. Cüneyt Balcioğlu ◽  
M. Kirami Ölgen ◽  
Fatih M. Şimsek ◽  
Seray Özensoy Töz ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Cutaneous Leishmaniasis ◽  
Sand Flies ◽  
Western Turkey ◽  
Phlebotomine Sand Flies

scholarly journals Some Epidemiological Aspects of Cutaneous Leishmaniasis in a New Focus, Central Iran

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
M. R. Yaghoobi-Ershadi ◽  
N. Marvi-Moghadam ◽  
R. Jafari ◽  
A. A. Akhavan ◽  
H. Solimani ◽  
...  
Keyword(s):  
Cutaneous Leishmaniasis ◽  
Primary Schools ◽  
Leishmania Major ◽  
Reservoir Host ◽  
Human Infection ◽  
Native People ◽  
Sand Fly ◽  
Animal Reservoir ◽  
Rural Districts ◽  
Tatera Indica

Following the epidemic of cutaneous leishmaniasis in Khatam County, Yazd Province, this study was carried out to determine vector, and animal reservoir host(s) and investigate the human infection during 2005-2006. Four rural districts where the disease had higher prevalence were selected. Sticky paper traps were used to collect sand flies during April to November, biweekly. Meanwhile rodents were captured using Sherman traps from August to November. Households and primary schools were visited and examined for human infection in February 2006. The parasite was detected by RAPD-PCR method. The rate of ulcers and scars among the inhabitants was 4.8% and 9.8%, respectively. Three rodent species were captured during the study:Meriones libycus, Rhombomys opimus, andTatera indica. Six sand fly species were also collected and identified; among themPhlebotomus papatasihad the highest frequency.Leishmania majorwas detected as the agent of the disease in the area. It was detected fromR. opimusand native people.

scholarly journals Analysis of salivary gland transcripts of the sand fly Lutzomyia ayacuchensis, a vector of Andean-type cutaneous leishmaniasis

2013 ◽  
Vol 13 ◽  
pp. 56-66 ◽  
Author(s):  
Hirotomo Kato ◽  
Ryan C. Jochim ◽  
Eduardo A. Gomez ◽  
Hiroshi Uezato ◽  
Tatsuyuki Mimori ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cutaneous Leishmaniasis ◽  
Sand Fly ◽  
Andean Type
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