Pregnancy‐Associated Pelvic Vein thrombosis: Insights from a Multicentre Case Series

2021 ◽  
Author(s):  
Marijke Allain Wouterlood ◽  
Isabelle Malhame ◽  
Kateri Levesque ◽  
Natalie Dayan ◽  
Michèle Mahone ◽  
...  
Keyword(s):  
Case Series ◽  
Pelvic Vein ◽  
Vein Thrombosis

scholarly journals Postmortem Demonstration of the Source of Pulmonary Thromboembolism: The Importance of the Autopsy

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Gina Elhammady ◽  
Andrew T. Schubeck ◽  
Vicky El-Najjar ◽  
Morton J. Robinson
Keyword(s):  
Pulmonary Embolism ◽  
Pulmonary Thromboembolism ◽  
Postmortem Examination ◽  
Pelvic Vein ◽  
Vein Thrombosis ◽  
Potential Source ◽  
Venous Thromboses

Periprostatic or paravaginal venous thromboses are rarely considered clinically as sites of clot origin in patients with pulmonary thromboembolism. The majority of emboli have been demonstrated to originate in the veins of the legs. This report raises awareness of pelvic vein thrombosis as a potential source of pulmonary embolism that is rarely considered or detected clinically, and which usually requires postmortem examination for recognition. It also reviews the possible routes emboli may take to reach the lungs.

Prophylaxis of Venous Thromboembolism Following Orthopedic Surgery: Mechanical and Pharmacological Approaches and the Need for Extended Prophylaxis

1999 ◽  
Vol 82 (08) ◽  
pp. 918-924 ◽  
Author(s):  
R.D. Hull ◽  
G.F Pineo
Keyword(s):  
Clinical Trials ◽  
Venous Thromboembolism ◽  
Orthopedic Surgery ◽  
Total Joint Replacement ◽  
Case Series ◽  
Pharmacological Agents ◽  
Thrombotic Disease ◽  
Vein Thrombosis ◽  
Major Orthopedic Surgery ◽  
Mechanical Devices

IntroductionMajor orthopedic surgery, particularly total joint replacement or hip fracture, represents a high risk of future development of postoperative venous thromboembolism and warrants the routine use of prophylaxis with either mechanical devices or pharmacological agents. The aim of prophylaxis is to prevent fatal pulmonary embolism (PE) and the morbidity of deep vein thrombosis (DVT), particularly the development of post-thrombotic syndrome. Patterns of clinical practice, with respect to the prevention of venous thromboembolism and the appropriate use of anticoagulants for the treatment of thrombotic disease, have been strongly influenced by recent consensus conferences.1,2 Rules of evidence for assessing the literature have been applied to all recommendations regarding the prevention and treatment of thrombotic disease. These results were extrapolated using evidence gleaned from major clinical disorders and are based only on nonrandomized clinical trials or case series.1-3 Data from a large number of Level I clinical trials in patients undergoing orthopedic surgery have provided answers to many of the questions regarding prophylaxis of venous thromboembolism. In this review, we will discuss the prevention of venous thromboembolism following orthopedic surgery and discuss some of the controversial issues where further studies are required.

scholarly journals Cerebral Vein Thrombosis in the Antiphospholipid Syndrome: Analysis of a Series of 27 Patients and Review of the Literature

2021 ◽  
Vol 11 (12) ◽  
pp. 1641
Author(s):  
Alba Jerez-Lienas ◽  
Alexis Mathian ◽  
Jenifer Aboab ◽  
Isabelle Crassard ◽  
Miguel Hie ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Medical Records ◽  
Case Reports ◽  
Case Series ◽  
Autoimmune Disorder ◽  
Point Of View ◽  
Cerebral Vein ◽  
Review Of The Literature ◽  
Cerebral Vein Thrombosis ◽  
Vein Thrombosis

(1) Background: The Antiphospholipid Syndrome (APS) is a systemic autoimmune disorder characterized by arterial and/or venous thrombosis, pregnancy morbidity and raised titers of antiphospholipid antibodies. Cerebral vein thrombosis (CVT) is a rare form of cerebrovascular accident and an uncommon APS manifestation; the information in the literature about this feature consists of case reports and small case series. Our purpose is to describe the particular characteristics of CVT when occurs as part of the APS and compare our series with the patients published in the literature. (2) Methods: We conducted a retrospective observational study collecting data from medical records in three referral centers for APS and CVT, and a systematic review of the literature for CVT cases in APS patients. (3) Results: Twenty-seven APS patients with CVT were identified in our medical records, the majority of them diagnosed as primary APS and with the CVT being the first manifestation of the disease; additional risk factors for thrombosis were identified. The review of the literature yielded 86 cases, with similar characteristics as those of our retrospective series. (4) Conclusions: To our knowledge, our study is the largest CVT series in APS patients published to date, providing a unique point of view in this rare thrombotic manifestation.

scholarly journals Catheter Directed Thrombolytic Therapy for Pediatric Cerebral Sinus Vein Thrombosis

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 3666-3666
Author(s):  
Marcela Torres ◽  
Tyler Hamby ◽  
Sarah Philip ◽  
Jo Ann Tilley
Keyword(s):  
Pediatric Patients ◽  
Randomized Clinical Trials ◽  
Conflicts Of Interest ◽  
Case Series ◽  
Protein S ◽  
Cerebral Veins ◽  
Vein Thrombosis ◽  
Partial Resolution ◽  
Neurologic Deficits ◽  
Cerebral Sinus

Background: Cerebral sinus vein thrombosis (CSVT) involves the thrombosis of the dural sinus and/or cerebral veins and it is considered a form of stroke. The estimated incidence of CSVT in children is 0.6 per 100,000 children per year. Poor outcomes, including death, happen in 9 to 29% of patients affected by CSVT. In addition, neurologic deficits, affecting primarily cognition and behavior, are seen in 50% of affected children. No randomized clinical trials have been conducted on pediatric CSVT so current guidelines for treatment have been extrapolated primarily from adult studies. Published guidelines by the American College of Chest Physicians, American Heart Association and American Society of Hematology, support the use of anticoagulation with unfractionated heparin (UFH) or low molecular weight heparin (LMWH). These same guidelines also suggest that catheter directed thrombolysis (CDT) with tissue plasminogen activator (tPA) and mechanical thrombectomy (MT) could be used when there has been clinical deterioration or no improvement (clot progression) despite anticoagulation. In all cases, these are based on uncontrolled case series and expert opinion. There is very little data on the safety and efficacy of CDT and/or MT for pediatric CSVT. Method: Pediatric patients with CSVT seen at Cook Children's Medical Center from January 1, 2008 to December 31, 2018 were identified by searching EMR using ICD-9 and ICD-10 codes. From this group, patients treated with MT and CDT in addition to anticoagulation were selected and reviewed. Results: Five children (4 to 14 y/o) were treated with MT and CDT after failing anticoagulation with UFH or LMWH. Diagnosis was made by MRI/MRV and all had CSVT of multiple sinuses. Four patients had more than one underlying disorders/factors that increased their risk for thrombosis including: Ulcerative Colitis in 2, severe anemia in 2, Systemic Lupus Erythematosus (SLE) in 1, use of oral contraceptives together with obesity and bacterial sepsis in 1. Two patients did have a thrombophilia: Protein S deficiency in 1 and Protein S and C deficiency in another. One patient with SLE had a positive hexagonal phase neutralization test but rest of evaluation was negative. Three patients had systemic bleeding prior initiation of UFH and MT/CDT. All children were treated with UFH, and due to clinical neurologic deterioration and/or worsening of imaging findings (4 comatose and 1 with persistent increased ICP), all underwent thromboaspiration and catheter directed infusion of tPA for 17 to 48 hours at a dose of 1 to 2 mg/hr. All patients continued anticoagulation with UFH during catheter directed tPA infusion and after the catheter was removed. All cases had partial resolution of the sinus vein thrombosis, although 1 had quick reocclusion. Post procedure bleeding happened in 1 patient who had also had an external ventricular drainage placed and developed parenchymal and intraventricular hemorrhage that led to discontinuation of tPA infusion, and 2 patients developed petechial brain hemorrhages. Four patients had great neurologic recovery and minimal deficits, but 1 had significant neurologic deficits. One patient died from lupus complications. (Table) Conclusion: Endovascular therapy including MT and CDT with tPA in conjunction with systemic UFH, may have a role in pediatric patients with CSVT who have deterioration despite initial anticoagulation. In our series, after procedures, all patients had partial resolution of their CSVT (but 1 had quick reocclusion) and 4 out of 5 patients had good neurologic outcomes despite bad predictor signs (coma, extensive CSVT). Further studies are needed to identify which patients would benefit from early endovascular treatment. Table Disclosures No relevant conflicts of interest to declare.

Color Doppler imaging versus phlebography in the diagnosis of deep leg and pelvic vein thrombosis

1997 ◽  
Vol 16 (1) ◽  
pp. 31-37 ◽  
Author(s):  
D Becker ◽  
E Günter ◽  
R Strauss ◽  
K Cidlinsky ◽  
B Tomandl ◽  
...  
Keyword(s):  
Color Doppler ◽  
Color Doppler Imaging ◽  
Doppler Imaging ◽  
Pelvic Vein ◽  
Vein Thrombosis

Postoperative pelvic vein thrombosis and pulmonary embolism detected by indium 111-labeled platelet imaging: A case report

1984 ◽  
Vol 149 (7) ◽  
pp. 796-798 ◽  
Author(s):  
Daniel L. Clarke-Pearson ◽  
R.Edward Coleman ◽  
Neil Petry ◽  
Ingrid S. Synan ◽  
William T. Creasman
Keyword(s):  
Pulmonary Embolism ◽  
Case Report ◽  
Pelvic Vein ◽  
Vein Thrombosis ◽  
Indium 111

Thromboembolism in Dogs with Protein-Losing Enteropathy with Non-Neoplastic Chronic Small Intestinal Disease

2017 ◽  
Vol 53 (3) ◽  
pp. 185-192 ◽  
Author(s):  
Ana M. L. Jacinto ◽  
Alison E. Ridyard ◽  
Itamar Aroch ◽  
Penny J. Watson ◽  
Linda R. Morrison ◽  
...  
Keyword(s):  
Serum Magnesium ◽  
Splenic Vein ◽  
Case Series ◽  
Intestinal Disease ◽  
Protein Losing Enteropathy ◽  
Vein Thrombosis ◽  
Increased Risk ◽  
Life Threatening ◽  
Small Intestinal ◽  
Small Intestinal Disease

ABSTRACT Dogs with protein-losing enteropathy (PLE) are suggested to be at increased risk of developing thromboembolic events. However, with some exceptions, there are very few reports of thromboembolism in such dogs. This multicentre retrospective observational study describes a case series of thromboembolism (TE) in eight dogs with PLE secondary to non-neoplastic, chronic small intestinal disease. Seven dogs had poorly controlled PLE when the thromboembolic event occurred. Pulmonary thromboembolism (PTE) occurred in six dogs, while one dog developed splenic vein thrombosis and another had concurrent splenic vein and aortic TE. Six dogs died, all with PTE. Antithrombin activity was decreased in one of two dogs in which it was measured. Serum cobalamin and folate concentrations were measured in three dogs and cobalamin was subnormal in all three. Serum magnesium, measured in two dogs, was low in both. Dogs with uncontrolled chronic small intestinal disease and PLE are at risk for developing serious life-threatening TE, mostly PTE.

Pelvic Vein Thrombosis as a Cause of Acute Pelvic Pain

2002 ◽  
Vol 99 (5, Part 2) ◽  
pp. 897-899
Author(s):  
Shree Devi Visaria ◽  
John D. Davis
Keyword(s):  
Pelvic Pain ◽  
Pelvic Vein ◽  
Vein Thrombosis ◽  
Acute Pelvic Pain

Frequency of pulmonary embolism in ambulant patients with pelvic vein thrombosis: A prospective study

1992 ◽  
Vol 16 (5) ◽  
pp. 0715-0722 ◽  
Author(s):  
H. Brownell Wheeler ◽  
Hugo Brownell Partsch ◽  
Karin Brownell Oburger ◽  
Adolf Brownell Mostbeck ◽  
Beatrix Brownell K[ouml ]nig
Keyword(s):  
Pulmonary Embolism ◽  
Prospective Study ◽  
Pelvic Vein ◽  
Vein Thrombosis ◽  
A Prospective Study
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