scholarly journals Postmortem Demonstration of the Source of Pulmonary Thromboembolism: The Importance of the Autopsy

2011 ◽  
Vol 2011 ◽  
pp. 1-3 ◽  
Author(s):  
Gina Elhammady ◽  
Andrew T. Schubeck ◽  
Vicky El-Najjar ◽  
Morton J. Robinson

Periprostatic or paravaginal venous thromboses are rarely considered clinically as sites of clot origin in patients with pulmonary thromboembolism. The majority of emboli have been demonstrated to originate in the veins of the legs. This report raises awareness of pelvic vein thrombosis as a potential source of pulmonary embolism that is rarely considered or detected clinically, and which usually requires postmortem examination for recognition. It also reviews the possible routes emboli may take to reach the lungs.

1984 ◽  
Vol 149 (7) ◽  
pp. 796-798 ◽  
Author(s):  
Daniel L. Clarke-Pearson ◽  
R.Edward Coleman ◽  
Neil Petry ◽  
Ingrid S. Synan ◽  
William T. Creasman

1992 ◽  
Vol 16 (5) ◽  
pp. 0715-0722 ◽  
Author(s):  
H. Brownell Wheeler ◽  
Hugo Brownell Partsch ◽  
Karin Brownell Oburger ◽  
Adolf Brownell Mostbeck ◽  
Beatrix Brownell K[ouml ]nig

Author(s):  
M. Nitharsha Prakash ◽  
N. N. Anand ◽  
Karthick Ramalingam ◽  
G. Venkat Sai

COVID-19 has been associated with multiple venous thromboembolism events such as pulmonary embolism and deep vein thrombosis. Here we report a 64-year male with COVID-19 pneumonia who developed pulmonary thromboembolism following the COVID illness. This patient developed VTE complication in spite of receiving anti-coagulation therapy during admission. This case brings out the need for evidence-based post-discharge VTE prophylaxis approach and guidelines in patients who recover from COVID-19.


2003 ◽  
Vol 37 (3) ◽  
pp. 518-522 ◽  
Author(s):  
Barbara Borst-Krafek ◽  
Astrid Maria Fink ◽  
Claudia Lipp ◽  
Helmut Umek ◽  
Horst Köhn ◽  
...  

2016 ◽  
Vol 01 (04) ◽  
pp. 032-035
Author(s):  
Seetharam Vankudoth ◽  
Madhurima banoth

AbstractVenous thromboembolism, causing Pulmonary Embolism (PE), is one of the major cardiovascular causes of death. We are reporting three cases of pulmonary thromboembolism without deep vein thrombosis and with normal levels of homocysteine, protein C and S, anti-thrombin III levels. All three cases managed with thrombolysis with streptokinase, out of three cases two cases systemic thrombolysis given and one case catheter guided thrombolysis given and discharged on oral anticoagulant with target range of PT with INR 2-3.on subsequent follow-up one case was diagnosed lymphoma and he was treated successfully in our institution.


2015 ◽  
Vol 39 (3-4) ◽  
pp. 216-223 ◽  
Author(s):  
Marcey Osgood ◽  
Elizabeth Budman ◽  
Raphael Carandang ◽  
Richard P. Goddeau, Jr. ◽  
Nils Henninger

Background: A substantial proportion of ischemic strokes has no any identified underlying cause. Notably, the prevalence of a patent foramen ovale (PFO) is increased in cryptogenic stroke (CS) populations, which may serve as a conduit for paradoxical emboli originating from deep vein thrombosis (DVT) including the pelvic veins. Yet, there are no published guidelines for the assessment of pelvic veins as part of the stroke workup and few studies have systematically investigated pelvic veins as a potential source for paradoxical emboli in CS patients. Further, there is a relative paucity of data regarding pelvic DVT in CS and results have been conflicting. Hence, we sought to determine the prevalence of pelvic DVT in select CS patients with PFO who underwent magnetic resonance venography (MRV). Methods: We retrospectively identified patients (n = 50) who underwent contrast-enhanced pelvic MRV at the discretion of the treating physician for the evaluation of CS in the presence of a PFO during hospitalization at a single academic stroke center between January 2011 through December 2013. Multivariable logistic regression analyses were used to assess for factors independently associated with the presence of an abnormal MRV pelvis. Results: Patients (47 ± 13 years of age) had MRV performed 4 ± 3 days after their incident stroke. Nine patients had an abnormal MRV (18%). Of these, four (8%) had pelvic vein thrombosis and 5 (10%) a May-Thurner anatomic variant. All patients with pelvic DVT were subsequently anticoagulated with warfarin (none had abnormal hypercoagulability testing). Clinical clues suggesting paradoxical embolism were present in as many as 40% of patients. On multivariable logistic regression, a history of any risk factors predisposing to DVT (OR 6.7; coefficient 1.9; BCa 95% CI 0.08-20.2; p = 0.014) as well as the number of predisposing risk factors (OR 3.9; coefficient 1.4; BCa 95% CI 0.25-4.2; p = 0.005) predicted the presence of pelvic vein pathology on MRV. Conclusion: We demonstrate a relatively high prevalence of pelvic DVT among select CS patients emphasizing the importance of considering the pelvic veins as a potential source for emboli particularly in the presence of risk factors known to predispose DVT. Because patients were included at the treating physician's discretion, our results reflect ‘real-life' practice. Our results may be of clinical importance as inclusion of pelvic vein imaging in CS patients with PFO had impactful therapeutic and nosologic implications. Further study is needed to define patients most likely to benefit from pelvic vein imaging.


1992 ◽  
Vol 16 (5) ◽  
pp. 715-722 ◽  
Author(s):  
Hugo Partsch ◽  
Karin Oburger ◽  
Adolf Mostbeck ◽  
Beatrix König ◽  
Horst Köhn

Author(s):  

Pulmonary embolism occurs when thrombi enter the pulmonary arterial circulation. Most pulmonary embolisms are the result of deep venous thrombosis of the pelvic limbs, chest or pelvis, and, less commonly, the jugular veins or inferior vena cava. Venous thromboembolism includes deep vein thrombosis and pulmonary embolism. It is the third most common cardiovascular disease, with a total annual incidence of 100-200 per 100 000 population. INTRODUCTION: Acute pulmonary embolism is the most serious clinical presentation of venous thromboembolism. Overall, pulmonary embolism is a major cause of mortality, morbidity and hospitalization. Mortality in pulmonary embolism depends on haemodynamic impairment, age and co morbidities. The prognosis of patients with pulmonary embolism depends on two factors : underlying disease state plus diagnosis, and appropriate treatment. Approximately 10% of patients who develop pulmonary embolism die within the first hour, and 30% subsequently die of recurrent embolism. CASE PRESENTATION: In this presentation we present the case of a 49-year-old male patient without co morbidities, presented repeatedly to the Emergency Room for symptoms suggestive of pulmonary thromboembolism, who benefited from life-saving therapies due to timely diagnosis and appropriate treatment, with subsequent favorable outcome. CONCLUSIONS: The particularity of the case is that, on the one hand, the thromboembolic event recurred in a short time, on the other hand, the evolution was favorable in both cases, with complete recovery of right ventricular function and disappearance of pulmonary hypertension, despite the fact that the patient was non-compliant with initial anticoagulation therapy. This was due to both early diagnosis and timely administration of appropriate treatment.


Author(s):  
Catarina Duarte Santos ◽  
Rita Lizardo Grácio ◽  
Tatiana Costa Pires ◽  
Miguel González Santos ◽  
Rita Jesus Rodrigues ◽  
...  

Proteus syndrome is an extremely rare disorder that manifests as an asymmetric, disproportionate overgrowth of any connective tissue, such as bone, fat or epidermal nevi, in a mosaic or patchy pattern. It has an estimated prevalence of less than 1/1,000,000 live births. The diagnosis can be difficult because the phenotypes of the patients are variable. Many individuals develop cutaneous capillary malformation and prominent varicosities (large and complex vascular malformations). Thus, Proteus syndrome patients are at risk of developing deep vein thrombosis and pulmonary embolism. The authors present the case of a patient with Proteus syndrome who was admitted because of pulmonary thromboembolism and presented hypertrophy of the left arm and left hemithorax.


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