scholarly journals Thromboelastography‐guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resuscitation: A systematic review and analysis

2019 ◽  
Vol 17 (6) ◽  
pp. 984-994 ◽  
Author(s):  
João D. Dias ◽  
Angela Sauaia ◽  
Hardean E. Achneck ◽  
Jan Hartmann ◽  
Ernest E. Moore
Transfusion ◽  
2020 ◽  
Vol 60 (11) ◽  
pp. 2581-2590
Author(s):  
Steven M. Frank ◽  
Brian D. Lo ◽  
Lekha V. Yesantharao ◽  
Kevin R. Merkel ◽  
Caroline X. Qin ◽  
...  

Transfusion ◽  
2019 ◽  
Vol 59 (12) ◽  
pp. 3639-3645
Author(s):  
Mereze Visagie ◽  
Caroline X. Qin ◽  
Brian C. Cho ◽  
Kevin R. Merkel ◽  
Tymoteusz J. Kajstura ◽  
...  

2018 ◽  
Vol 129 (6) ◽  
pp. 1082-1091 ◽  
Author(s):  
Pranjal B. Gupta ◽  
Vince M. DeMario ◽  
Raj M. Amin ◽  
Eric A. Gehrie ◽  
Ruchika Goel ◽  
...  

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Although randomized trials show that patients do well when given less blood, there remains a persistent impression that orthopedic surgery patients require a higher hemoglobin transfusion threshold than other patient populations (8 g/dl vs. 7 g/dl). The authors tested the hypothesis in orthopedic patients that implementation of a patient blood management program encouraging a hemoglobin threshold less than 7 g/dl results in decreased blood use with no change in clinical outcomes. Methods After launching a multifaceted patient blood management program, the authors retrospectively evaluated all adult orthopedic patients, comparing transfusion practices and clinical outcomes in the pre- and post-blood management cohorts. Risk adjustment accounted for age, sex, surgical procedure, and case mix index. Results After patient blood management implementation, the mean hemoglobin threshold decreased from 7.8 ± 1.0 g/dl to 6.8 ± 1.0 g/dl (P < 0.0001). Erythrocyte use decreased by 32.5% (from 338 to 228 erythrocyte units per 1,000 patients; P = 0.0007). Clinical outcomes improved, with decreased morbidity (from 1.3% to 0.54%; P = 0.01), composite morbidity or mortality (from 1.5% to 0.75%; P = 0.035), and 30-day readmissions (from 9.0% to 5.8%; P = 0.0002). Improved outcomes were primarily recognized in patients 65 yr of age and older. After risk adjustment, patient blood management was independently associated with decreased composite morbidity or mortality (odds ratio, 0.44; 95% CI, 0.22 to 0.86; P = 0.016). Conclusions In a retrospective study, patient blood management was associated with reduced blood use with similar or improved clinical outcomes in orthopedic surgery. A hemoglobin threshold of 7 g/dl appears to be safe for many orthopedic patients.


2020 ◽  
Vol 15 (03) ◽  
pp. 239-255
Author(s):  
Lea Valeska Blum ◽  
Hendrik Kohlhof ◽  
Dieter Wirtz ◽  
Kai Zacharowski ◽  
Patrick Meybohm

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