scholarly journals Hippocampal and medial prefrontal cortical volume is associated with overnight declarative memory consolidation independent of specific sleep oscillations

2020 ◽  
Vol 29 (5) ◽  
Author(s):  
Lukas Frase ◽  
Wolfram Regen ◽  
Stéphanie Kass ◽  
Albena Rambach ◽  
Chiara Baglioni ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Declarative Memory ◽  
Cortical Volume ◽  
Prefrontal Cortical ◽  
Medial Prefrontal Cortical

Pharmacologically Increasing Sleep Spindles Enhances Recognition for Negative and High-arousal Memories

2013 ◽  
Vol 25 (10) ◽  
pp. 1597-1610 ◽  
Author(s):  
Erik J. Kaestner ◽  
John T. Wixted ◽  
Sara C. Mednick
Keyword(s):  
Rem Sleep ◽  
Memory Consolidation ◽  
Declarative Memory ◽  
Memory Performance ◽  
Emotional Memory ◽  
Limited Range ◽  
Sleep Spindles ◽  
Sleep Spindle ◽  
Emotional Stimuli ◽  
Valence And Arousal

Sleep affects declarative memory for emotional stimuli differently than it affects declarative memory for nonemotional stimuli. However, the interaction between specific sleep characteristics and emotional memory is not well understood. Recent studies on how sleep affects emotional memory have focused on rapid eye movement sleep (REM) but have not addressed non-REM sleep, particularly sleep spindles. This is despite the fact that sleep spindles are implicated in declarative memory as well as neural models of memory consolidation (e.g., hippocampal neural replay). Additionally, many studies examine a limited range of emotional stimuli and fail to disentangle differences in memory performance because of variance in valence and arousal. Here, we experimentally increase non-REM sleep features, sleep spindle density, and SWS, with pharmacological interventions using zolpidem (Ambien) and sodium oxybate (Xyrem) during daytime naps. We use a full spread of emotional stimuli to test all levels of valence and arousal. We find that increasing sleep spindle density increases memory discrimination (da) for highly arousing and negative stimuli without altering measures of bias (ca). These results indicate a broader role for sleep in the processing of emotional stimuli with differing effects based on arousal and valence, and they raise the possibility that sleep spindles causally facilitate emotional memory consolidation. These findings are discussed in terms of the known use of hypnotics in individuals with emotional mood disorders.

5-HT1aagonist ±- 8-OH-DPAT modulates basal and stress-induced changes in medial prefrontal cortical dopamine

Synapse ◽  
1994 ◽  
Vol 18 (3) ◽  
pp. 218-224 ◽  
Author(s):  
Ann M. Rasmusson ◽  
Lee E. Goldstein ◽  
Ariel Y. Deutch ◽  
Benjamin S. Bunney ◽  
Robert H. Roth
Keyword(s):  
Prefrontal Cortical ◽  
Induced Changes ◽  
Medial Prefrontal Cortical

scholarly journals The Neural Sociometer: Brain Mechanisms Underlying State Self-esteem

2011 ◽  
Vol 23 (11) ◽  
pp. 3448-3455 ◽  
Author(s):  
Naomi I. Eisenberger ◽  
Tristen K. Inagaki ◽  
Keely A. Muscatell ◽  
Kate E. Byrne Haltom ◽  
Mark R. Leary
Keyword(s):  
Negative Feedback ◽  
Cortical Activity ◽  
Self Esteem ◽  
Anterior Insula ◽  
Lower State ◽  
Social Connection ◽  
Prefrontal Cortical ◽  
Referential Processing ◽  
Neural Underpinnings ◽  
Medial Prefrontal Cortical

On the basis of the importance of social connection for survival, humans may have evolved a “sociometer”—a mechanism that translates perceptions of rejection or acceptance into state self-esteem. Here, we explored the neural underpinnings of the sociometer by examining whether neural regions responsive to rejection or acceptance were associated with state self-esteem. Participants underwent fMRI while viewing feedback words (“interesting,” “boring“) ostensibly chosen by another individual (confederate) to describe the participant's previously recorded interview. Participants rated their state self-esteem in response to each feedback word. Results demonstrated that greater activity in rejection-related neural regions (dorsal ACC, anterior insula) and mentalizing regions was associated with lower-state self-esteem. Additionally, participants whose self-esteem decreased from prescan to postscan versus those whose self-esteem did not showed greater medial prefrontal cortical activity, previously associated with self-referential processing, in response to negative feedback. Together, the results inform our understanding of the origin and nature of our feelings about ourselves.

Medial prefrontal cortical lesions modulate baroreflex sensitivity in the rat

1987 ◽  
Vol 426 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Anthony J.M. Verberne ◽  
Stephen J. Lewis ◽  
Peter J. Worland ◽  
Philip M. Beart ◽  
Bevyn Jarrott ◽  
...  
Keyword(s):  
Baroreflex Sensitivity ◽  
Cortical Lesions ◽  
Prefrontal Cortical ◽  
Medial Prefrontal Cortical

036 The Effect of Exercise on Sleep Architecture and Memory Consolidation during a Daytime Nap

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A16-A16
Author(s):  
Megan Collins ◽  
Erin Wamsley ◽  
Hailey Napier ◽  
Madeline Ray
Keyword(s):  
Slow Wave ◽  
Memory Consolidation ◽  
Slow Wave Sleep ◽  
Declarative Memory ◽  
Sleep Stage ◽  
Sleep Time ◽  
Learning Task ◽  
Memory Retention ◽  
Verbal Information ◽  
Significant Difference

Abstract Introduction Slow wave sleep (SWS) is thought to especially benefit declarative memory (i.e., memory for facts and events). As such, recent studies have used various methods to experimentally increase the amount of slow wave sleep that participants obtain, with the goal of assessing how SWS affects declarative memory consolidation. Studies dating back decades have reported that exercising before sleep may increase time spent in SWS. Thus, the aim of the current project was to determine whether exercising after learning verbal information enhances slow wave sleep during a subsequent nap and/or enhances memory for verbal information. Methods Participants who exercised regularly were recruited to attend two 2.5hr laboratory sessions. During each session, they trained on a paired associates learning task and then completed either a 20min cardiovascular exercise routine or a 20min stretching routine. Following a 1hr nap opportunity, participants were tested on their memory. PSG was recorded during the nap, and scored following AASM criteria. Participants were excluded from analysis if they failed to sleep for at least 10 min. Following exclusions, n=30 participants were included in analysis. Results Contrary to our hypotheses, there was no significant difference between the exercise and stretching conditions for minutes spent in slow wave sleep (p=.16), % time spent in slow wave sleep (p=.22), or raw improvement in paired associated performance (p=.23). The amount of SWS obtained during the nap did not correlate with performance in either condition (SWS min vs. memory in exercise condition: r28=.10, p=.60; sleep condition: r28=-.06, p=.74). Exercise did not affect time spent in any other sleep stage, nor did it affect total sleep time. Conclusion Contrary to our hypotheses and the results of prior research, we were unable to detect a significant effect of exercise on slow wave sleep. Also contrary to our hypotheses, exercise did not affect memory retention across the nap interval. These null results could indicate that there is no effect of exercise on nap sleep and/or associated memory retention. However, it could also be that we lacked sufficient power to detect effects that were smaller than expected. Support (if any):

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